The development and optimisation of 3D black-blood R2* mapping of the carotid artery wall

Yuan, Jianmin; Graves, Martin J.; Patterson, Andrew J.; Priest, Andrew N.; Ruetten, Pascal P R; Usman, Ammara; Gillard, Jonathan H.

doi:10.1016/j.mri.2017.08.006

Cited by 4 publications

(4 citation statements)

References 36 publications

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“…To our knowledge this is the first report in the published literature to have used this comprehensive quantitative analysis for the evaluation of ferumoxytol-enhanced MR imaging in carotid artery territory. Development of this quantitative mapping method has been described by our group previously 15 .…”

Section: Discussionmentioning

confidence: 99%

“…The decreased T 1 of blood after ferumoxytol infusion would likely influence the accuracy of T 2 /T 2 * measurements at this time-point. The multi-echo fast gradient echo T 2 * weighted sequence is also sensitive to the smallest changes in magnetic field, hence when the paramagnetic contrast medium (like ferumoxytol) reaches the neovessel of the atherosclerotic plaque for the first time, the sequence can detect these changes sensitively, which appears as a decrease in signal intensity on this pulse sequence and simultaneous amplification of artefacts caused by insufficient blood suppression due to above reason 15 .…”

Section: Discussionmentioning

confidence: 99%

“…The following pulse sequences were used: T 1 w images were acquired using a 3D variable refocusing flip angle fast spin echo sequence with Delayed Alternating with Nutation for Tailored Excitation blood suppression preparation. qT2* mapping was performed using a multi-echo fast gradient echo sequence using DANTE blood suppression preparation 15 . Six echoes were used as in our experience it is a good balance for the required imaging field of view and matrix size for the carotid study.…”

Section: Mr Imagingmentioning

confidence: 99%

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Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study

Usman

Patterson

Yuan

et al. 2020

Sci Rep

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ferumoxytol is an ultrasmall super paramagnetic particles of iron oxide (USpio) agent recently used for magnetic resonance (MR) vascular imaging. other USpios have been previously used for assessing inflammation within atheroma. We aim to assess feasibility of ferumoxytol in imaging carotid atheroma (with histological assessment); and the optimum MR imaging time to detect maximum quantitative signal change post-ferumoxytol infusion. ten patients with carotid artery disease underwent highresolution MR imaging of their carotid arteries on a 1.5 T MR system. MR imaging was performed before and at 24, 48, 72 and 96 hrs post ferumoxytol infusion. Optimal ferumoxytol uptake time was evaluated by quantitative relaxometry maps indicating the difference in T 2 * (Δt 2 *) and t 2 (Δt 2) between baseline and post-Ferumoxytol MR imaging using 3D DANTE MEFGRE qT 2 *w and iMSDE black-blood qt 2 w sequences respectively. 20 patients in total (10 symptomatic and 10 with asymptomatic carotid artery disease) had ferumoxytol-enhanced MR imaging at the optimal imaging window. 69 carotid MR imaging studies were completed. Ferumoxytol uptake (determined by a decrease in Δt 2 * and Δt 2) was identified in all carotid plaques (symptomatic and asymptomatic). Maximum quantitative decrease in Δt 2 * (10.4 [3.5-16.2] ms, p < 0.001) and Δt 2 (13.4 [6. 2-18.9] ms; p = 0.001) was found on carotid MR imaging at 48 hrs following the ferumoxytol infusion. Ferumoxytol uptake by carotid plaques was assessed by histopathological analysis of excised atheroma. ferumoxytol-enhanced MR imaging using quantitative 3D MR pulse sequences allows assessment of inflammation within carotid atheroma in symptomatic and asymptomatic patients. The optimum MR imaging time for carotid atheroma is 48 hrs after its administration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Mr Imagingmentioning

confidence: 99%

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Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study

Usman

Patterson

Yuan

et al. 2020

Sci Rep

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“…Previous work has shown that multi-contrast MRI can characterize high risk plaque components. 3–8 Besides the traditional “weighted” images, there are several studies which have performed quantitative measurements of the vessel wall and major plaque components’ relaxation times both in vivo and ex vivo 9–14…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Black-blood T<sub>2</sub> Mapping Sequences for Carotid Vessel Wall Imaging at 3T: An Assessment of Accuracy and Repeatability

et al. 2019

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Purpose: This study is to compare the accuracy of four different black-blood T 2 mapping sequences in carotid vessel wall. Methods: Four different black-blood T 2 mapping sequences were developed and tested through phantom experiments and 17 healthy volunteers. The four sequences were: 1) double inversion-recovery (DIR) prepared 2D multi-echo spin-echo (MESE); 2) DIR-prepared 2D multi-echo fast spin-echo (MEFSE); 3) improved motion-sensitized driven-equilibrium (iMSDE) prepared 3D FSE and 4) iMSDE prepared 3D fast spoiled gradient echo (FSPGR). The concordance correlation coefficient and Bland-Altman statistics were used to compare the sequences with a gold-standard 2D MESE, without blood suppression in phantom studies. The volunteers were scanned twice to test the repeatability. Mean and standard deviation of vessel wall T 2 , signal-to-noise (SNR), the coefficient of variance and interclass coefficient (ICC) of the two scans were compared. Results:The phantom study demonstrated that T 2 measurements had high concordance with respect to the gold-standard (all r values >0.9). In the volunteer study, the DIR 2D MEFSE had significantly higher T 2 values than the other three sequences (P < 0.01). There was no difference in T 2 measurements obtained using the other three sequences (P > 0.05). iMSDE 3D FSE had the highest SNR (P < 0.05) compared with the other three sequences. The 2D DIR MESE has the highest repeatability (ICC: 0.96, [95% CI: 0.88-0.99]). Conclusion: Although accurate T 2 measurements can be achieved in phantom by the four sequences, in vivo vessel wall T 2 quantification shows significant differences. The in vivo images can be influenced by multiple factors including black-blood preparation and acquisition method. Therefore, a careful choice of acquisition methods and analysis of the confounding factors are required for accurate in vivo carotid vessel wall T 2 measurements. From the settings in this study, the iMSDE prepared 3D FSE is preferred for the future volunteer/ patient scans.

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Advancements in non-invasive imaging of atherosclerosis: Future perspectives

Guimarães,

de Almeida,

Mendes

et al. 2024

Journal of Clinical Lipidology

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The development and optimisation of 3D black-blood R2* mapping of the carotid artery wall

Cited by 4 publications

References 36 publications

Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study

Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study

A Comparison of Black-blood T<sub>2</sub> Mapping Sequences for Carotid Vessel Wall Imaging at 3T: An Assessment of Accuracy and Repeatability

Advancements in non-invasive imaging of atherosclerosis: Future perspectives

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