The purpose of this study was to investigate the effects of the Korean Smart Home Modification Program (KSHMP) on the activities of daily living and health-related quality of life of people with physical disabilities. The study used a single-group pre-post design with 10 people with physical disabilities living at home. During the intervention period, the KSHMP was implemented, which included occupational profile, smart home installation, setup, training, task-based feedback, and monitoring. Post-intervention changes in activities of daily living and health-related quality of life were assessed with the Canadian Occupational Performance Measure (COPM) and EuroQual-5 Dimensions (EQ-5D). After the KSHMP, all 10 subjects improved their activities of daily living and quality of life. In addition, the occupational performance of all subjects was maintained. These results show that a customized smart home has a positive impact on improving the activities of daily living and quality of life of people with retardation and is an efficient alternative.