This study details the design and implementation of an online materials chemistry general education (GE) course during the COVID-19 pandemic. While many pedagogical techniques involving active learning have been established in STEM major courses, their use within STEM general education courses for non-majors are not as well-established. The recently developed GE course at UCLA (termed Chemistry 3: Material World) utilized high-impact practices to introduce students to the scientific process and impart skills of critical thinking and scientific communication through its flexible activities and assignments. Emphasis was placed on collaborative learning, problem-solving, and interpreting scientific information from published reports. Additionally, content focused on social justice and community engagement was introduced throughout several topics (e.g., underrepresentation in science, war on drugs, nuclear proliferation, pollution, and global climate change) to showcase that chemistry is intricately related to bigger societal challenges. This article details our efforts in achieving the course learning outcomes and shares tangible results regarding the assessment of our teaching strategies from student feedback and reflections. We envision that this work will assist faculty in designing inclusive chemistry GE courses that focus on process versus content and adopting our teaching strategies in both in-person and online classrooms.