The development of 5-fluorouracil biodegradable implants: A comparative study of PCL/PLGA blends

Youssef, Souha H.; Kim, Sangseo; Khetan, Riya; Afinjuomo, Franklin; Song, Yunmei; Garg, Sanjay

doi:10.1016/j.jddst.2023.104300

Cited by 11 publications

(6 citation statements)

References 59 publications

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“…The T g remained mainly constant in all the thermograms, in the presence of the drugs (49 °C for C1 and 48 °C for C2), indicating that there is no plasticizer effect and there is chemical compatibility between all the components . No endothermic peak is detected in C1, suggesting that RIV is molecularly dispersed into the PLGA matrix . However, C2 presents an endothermic peak attributed to NAC, indicating that NAC is in the crystalline form into the particles .…”

Section: Resultsmentioning

confidence: 96%

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Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Monou,

Andriotis,

Tzetzis

et al. 2024

ACS Appl. Bio Mater.

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In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes were designed, printed, and coated with PLGA particles containing two different actives. Rivastigmine (RIV) and N-acetyl-cysteine (NAC) were coformulated via electrohydrodynamic atomization (EHDA), and they were incorporated into the PLGA particles. The two actives are administered as a combined therapy for Alzheimer’s disease. The printed arrays were evaluated regarding their ability to penetrate skin and their mechanical properties. Optical microscopy and scanning electron microscopy (SEM) were employed to further characterize the microneedle structure. Confocal laser microscopy studies were conducted to construct 3D imaging of the coating and to simulate the diffusion of the particles through artificial skin samples. Permeation studies were performed to investigate the transport of the drugs across human skin ex vivo. Subsequently, a series of tape strippings were performed in an attempt to examine the deposition of the APIs on and within the skin. Light microscopy and histological studies revealed no drastic effects on the membrane integrity of the stratum corneum. Finally, the cytocompatibility of the microneedles and their precursors was evaluated by measuring cell viability (MTT assay and live/dead staining) and membrane damages followed by LDH release.

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Section: Resultsmentioning

confidence: 96%

“…45 No endothermic peak is detected in C1, suggesting that RIV is molecularly dispersed into the PLGA matrix. 46 However, C2 presents an endothermic peak attributed to NAC, indicating that NAC is in the crystalline form into the particles. 47 TGA thermograms of C1, C2, and pure materials are presented in Figure 2C.…”

Section: ■ Materials and Methodsmentioning

confidence: 98%

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Monou,

Andriotis,

Tzetzis

et al. 2024

ACS Appl. Bio Mater.

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“…2b and d). 36,37 Therefore, we focused on the PLGA/PLLA nanofibrous composite membranes in this study.…”

Section: Resultsmentioning

confidence: 99%

Automatic in situ short-distance deposition of PLGA/PLLA composite nanofibrous membranes for personalized wound dressings

Liu,

Xia,

Zhao

et al. 2024

Nanoscale

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“…Another investigation involved the development of solvent cast films containing different ratios of PCL:Poly(lactide-co-glycolide) (PLGA). Formulations with higher concentrations of PLGA and triethyl citrate as plasticizer showed a lower burst effect, while higher 5-Fluorouracil (5FU, an anticancer drug) loading (2%) resulted in an increased release rate [158].…”

Section: Pcl Blends/composites For Drug Deliverymentioning

confidence: 99%

Polycaprolactone Composites/Blends and Their Applications Especially in Water Treatment

Kayan,

Kayan

2023

ChemEngineering

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Biodegradable poly(ɛ-caprolactone) (PCL) and its composites or blends have received a lot of attention in the last decade because of their potential applications in human life and environmental remediation. Greater efforts have been made to develop biodegradable chemical materials as adsorbents that do not pollute the environment in order to replace traditional materials. Among the numerous types of degradable materials, PCL is currently the most promising, the most popular, and the best material to be developed, and it is referred to as a “green” eco-friendly material. Membranes and adsorbents for water treatment, packaging and compost bags, controlled drug carriers, and biomaterials for tissues such as bone, cartilage, ligament, skeletal muscle, skin, cardiovascular and nerve tissues are just some of the applications of this biodegradable polymer (PCL). The goal of this review is to present a brief overview of PCL, syntheses of PCL, its properties, PCL composites, and PCL blends and to provide a detailed investigation into the utility of PCL/PCL-based adsorbing agents in the removal of dyes/heavy metal ions. Overall, it can be confirmed that PCL blends and composites were found to be significant competitors to other well-known adsorbents in the treatment of wastewaters, necessitating a thorough investigation of their manufacture.

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The development of 5-fluorouracil biodegradable implants: A comparative study of PCL/PLGA blends

Cited by 11 publications

References 59 publications

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Automatic in situ short-distance deposition of PLGA/PLLA composite nanofibrous membranes for personalized wound dressings

Polycaprolactone Composites/Blends and Their Applications Especially in Water Treatment

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