The Development of Adaptive Optics and Its Application in Ophthalmology

Jayabalan, Gopal Swamy; Bille, Josef F.

doi:10.1007/978-3-030-16638-0_16

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…The laser treatment system used in this study was the non-commercially available research device called Spectralis Centaurus (HuCE-optoLab, Bern University of Applied Sciences, Biel, Switzerland) [ 12 ]. This system is based on a diagnostic imaging system (Spectralis, Heidelberg Engineering, Heidelberg, Germany) and was extended by an LPC treatment laser (Merilas 532 shortpulse, Meridian Medical, Thun, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, this study aimed to combine OCT imaging for reliable detection of retinal breaks, fundus imaging for planning and control of treatment position, and a navigated laser for optimal laser placement and application. The platform used for this purpose is a noncommercially available prototype that combines live fundus imaging, OCT, and a steerable treatment laser [ 12 ]. The goal was to develop and implement a novel method for navigated, OCT-guided treatment of retinal breaks.…”

Section: Introductionmentioning

confidence: 99%

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High-Precision Optical Coherence Tomography Navigated Laser Retinopexy for Retinal Breaks

Salzmann

Wakili

Al-Nawaiseh

et al. 2023

Life

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The prevalent cause of retinal detachment is a full-thickness retinal break and the ingress of fluid into the subretinal space. To prevent progression of the detachment, laser photocoagulation (LPC) lesions are placed around the break in clinical practice to seal the tissue. Unlike the usual application under indirect ophthalmoscopy, we developed a semi-automatic treatment planning software based on a sequence of optical coherence tomography (OCT) scans to perform navigated LPC treatment. The depth information allows demarcation of the border where the neurosensory retina is still attached to the retinal pigment epithelium (RPE), which is critical for prevention of detachment progression. To evaluate the method, artificially provoked retinal breaks were treated in seven ex-vivo porcine eyes. Treatment outcome was assessed by fundus photography and OCT imaging. The automatically applied lesions surrounding each detachment (4.4–39.6 mm2) could be identified as highly scattering coagulation regions in color fundus photography and OCT. Between the planned and applied pattern, a mean offset of 68 µm (SD ± 16.5 µm) and a mean lesion spacing error of 5 µm (SD ± 10 µm) was achieved. The results demonstrate the potential of navigated OCT-guided laser retinopexy to improve overall treatment accuracy, efficiency, and safety.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High-Precision Optical Coherence Tomography Navigated Laser Retinopexy for Retinal Breaks

Salzmann

Wakili

Al-Nawaiseh

et al. 2023

Life

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“…For the experiments, the non-commercially available research device Spectralis Centaurus (HuCE-optoLab, Bern University of Applied Sciences, Biel, CH) was used [ 53 ]. This device is based on a modified diagnostic imaging platform (Spectralis, Heidelberg Engineering, Heidelberg, DE), extended with a prototype treatment laser (modified Merilas 532 shortpulse, Meridian Medical, Thun, CH) intended for SRT.…”

Section: Methodsmentioning

confidence: 99%

Real-time OCT feedback-controlled RPE photodisruption in ex vivo porcine eyes using 8 microsecond laser pulses

Burri,

Salzmann,

Wandel

et al. 2023

Biomed. Opt. Express

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Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength: 532 nm, exposure area: 90 × 90 µm2, radiant exposure: 247 to 1975 mJ/µm2). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength: 870 nm, scan rate: 85 kHz) were compared to an RPE cell viability assay. Statistical analysis revealed a moderate correlation between RPE lesion size and applied treatment energy, suggesting RFD adaptation to inter- and intraindividual RPE pigmentation and ocular transmission.

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“…By using wavefront technology first utilized in astronomy and defense systems, adaptive optics (AO) systems have been implemented in ophthalmology with the goal of correcting for ocular anatomical and physiological higher order (optical/wavefront) aberrations (cornea, lens, and pupil), which cannot be corrected by glasses, contact lenses or refractive surgery ( 260 ). As a result, AO vastly improves the transverse (lateral) resolution as well as the speckle width and increases the SNR via imaging through a larger pupil, allowing more light to enter the eye.…”

Section: Adaptive Opticsmentioning

confidence: 99%

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

et al. 2022

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The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new technologies and imaging methods can be utilized in a clinical setting. The introduction of optical coherence tomography (OCT) was a revolution in eye imaging and has since become the standard of care for a plethora of conditions. Its most recent iterations, OCT angiography, and visible light OCT, as well as imaging modalities, such as fluorescent lifetime imaging ophthalmoscopy, would allow a more thorough evaluation of patients and provide additional information on disease processes. Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and anterior segment. Toward the goal of remote eye care and more accessible eye imaging, methods such as handheld OCT devices and imaging through smartphones, have emerged. Finally, incorporating artificial intelligence (AI) in eye images has the potential to become a new milestone for eye imaging while also contributing in social aspects of eye care.

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The Development of Adaptive Optics and Its Application in Ophthalmology

Cited by 7 publications

References 20 publications

High-Precision Optical Coherence Tomography Navigated Laser Retinopexy for Retinal Breaks

High-Precision Optical Coherence Tomography Navigated Laser Retinopexy for Retinal Breaks

Real-time OCT feedback-controlled RPE photodisruption in ex vivo porcine eyes using 8 microsecond laser pulses

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

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