The development of allergy in high‐risk children

Burr, Michael Leslie; Merrett, T. G.; Dunstan, Frank David John; Maguire, M. J.

doi:10.1111/j.1365-2222.1997.tb01168.x

Cited by 114 publications

(80 citation statements)

References 40 publications

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“…For dog sensitization in this study, too few were sensitized to comment [2]. Two studies, from the United Kingdom [10] and the United States [11••], reported on allergic sensitization. The UK study found a decrease in the risk for allergic sensitization using immunoglobulin E (IgE) (AlaTOP multiallergen screen) for those with a cat or dog in infancy; the authors comment that the effect was greater for dogs than cats but do not present this data separately.…”

Section: Birth Cohort Studiesmentioning

confidence: 94%

“…Two found no association [6,9], and one reported a reduced risk among dog owners [7••]. For sensitization to other allergens, one found no association [5••], and three found a reduced risk with dogs or cats [10], with two or more required in one study [7••], or dogs alone [11••].…”

Section: Birth Cohort Studiesmentioning

confidence: 98%

“…The UK study found a decrease in the risk for allergic sensitization using immunoglobulin E (IgE) (AlaTOP multiallergen screen) for those with a cat or dog in infancy; the authors comment that the effect was greater for dogs than cats but do not present this data separately. However, when allergic sensitization was defined as one or more positive skin test, there was no association with pet ownership [10]. In the smaller Childhood Origins of Asthma study, dog ownership was associated with a reduced risk for allergic sensitization on skin test at age 1 year, with no association for cat [11••].…”

Section: Birth Cohort Studiesmentioning

confidence: 99%

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Pets and the development of allergic sensitization

Simpson

Čustović

2005

Curr Allergy Asthma Rep

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Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. Several reports have indicated that living with a pet reduces the risk for becoming sensitized to that pet. Having a pet in the home gives exposure to more than just allergens. In areas with high frequency of pet ownership, community exposure to pet allergens is almost certainly sufficient to induce sensitization among non-pet owners. In this review, we examine the results of recent studies that have investigated the relationship between pet ownership, specific sensitization to that pet, and allergic sensitization in general. For cat ownership, the results are inconsistent between studies of similar design, with some studies suggesting an increase in risk and others a decrease among cat owners. For dogs, results are more consistent, generally suggesting that owning a dog has no effect or indeed may be protective against the development of specific sensitization to dog and allergic sensitization in general.

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Section: Birth Cohort Studiesmentioning

confidence: 94%

Section: Birth Cohort Studiesmentioning

confidence: 98%

Section: Birth Cohort Studiesmentioning

confidence: 99%

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Pets and the development of allergic sensitization

Simpson

Čustović

2005

Curr Allergy Asthma Rep

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“…During the last decades, 31 prospective birth cohort studies have been carried out to investigate the relations between potential risk factors and atopic disorders. More recently, a growing interest has been shown in testing the impact of environmental exposure on atopic diseases: these studies have been conducted worldwide [12][13][14][15][16][17][18], with half of them in European countries [8,[19][20][21][22][23][24][25][26][27]. But to the best of our knowledge, no data from longitudinal birth cohort study on relations between French environmental conditions and behavioural habits and atopic manifestations occurrence are available today.…”

Section: Introductionmentioning

confidence: 98%

The Paris prospective birth cohort study: Which design and who participates?

et al. 2007

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The Paris prospective birth cohort study was implemented in 2003 to assess environmental/behavioural factors associated with respiratory and allergic disorder occurrence in early childhood. This paper describes the design and sociodemographic features of eligible/enrolled families. Full-term newborns without any medical problem at birth were recruited in five Paris maternity hospitals. They resided in the Paris area and had French speaking mothers. Sample size is at least 3500 infants, and children are followed-up until their sixth birthday. Data collection is based on regular medical and environmental self-administered questionnaires to parents. Information on dwellings is gathered by means of phone questionnaires, and standardized medical examinations are carried out at 18 months and 6 years. Exposure to traffic-related pollution is modelled. At inclusion, some information concerning refusals is gathered in order to describe sociodemographic features of participating families as compared with eligible children. 4115 (63%) out of the 6493 eligible infants are now participating in this study. Participation rate is higher in parents with a high SES (socioeconomic status), for French and European parents, and for > or =25-year-old mothers, but decreases with sibship size. Similar determinants are associated with the distribution of reasons for non-participation. The participation rate in the Paris study is comparable with other similar studies. Finally, giving detailed explanation of the study aims at inclusion, establishing regular mailed and phoned contacts with families, offering free complete medical examinations for the participant child and re-sent missing questionnaires are very important to improve participation at inclusion and during follow-up.

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“…However, these studies have also not yielded completely consistent results, and the controversy continues. Some of these studies indicate that early exposure to animal allergens, especially in the first year of life, may protect against the development of allergic disease in childhood [5••], whereas others have found that early pet exposure does not seem to influence the development of allergic sensitization [6][7][8]. In this article, we review the recent data on early exposure to animal allergens in regard to the development of allergic sensitization and atopic disease.…”

Section: Introductionmentioning

confidence: 98%

Animal allergens

Partridge

Wood²

2005

Curr Allergy Asthma Rep

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Animal allergen exposure in early childhood and its relationship to the development of atopic disease is a subject that has been evolving rapidly. Recently, several well-designed studies have helped elucidate previous, often conflicting findings on this topic. In addition, results from studies on farm-animal exposure have added strength to data on early dog and cat exposure. In this paper, we review several recent studies that have helped clarify the relationship between early animal-allergen exposure and childhood atopic disease.

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The development of allergy in high‐risk children

Abstract: Allergic disease in childhood is to a large degree determined before birth or during infancy.

Cited by 114 publications

References 40 publications

Pets and the development of allergic sensitization

Pets and the development of allergic sensitization

The Paris prospective birth cohort study: Which design and who participates?

Animal allergens

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