The development of an alginate/polycaprolactone composite scaffold for in situ transfection application

Hu, Wei; Wu, Yun; Hu, Zhe Chen

doi:10.1016/j.carbpol.2017.11.030

Cited by 45 publications

(21 citation statements)

References 26 publications

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“…Wei and Hsieh prepared the SA/PVA hybrid fibers via aqueous electrospinning method which rendered the hybrid fibers water insolubility by crosslinking with CaCl 2 in EtOH. Hu et al . prepared alginate/poly(caprolactone) composite nanofibros scaffolds using a dual‐jet co‐eletrospinning system, and found that both chemical properties and hydrophobicity of scaffolds were manipulated by regulating the perfusion rates of polymer jets.…”

Section: Introductionmentioning

confidence: 99%

Improvement in mechanical and hygroscopic properties of modified SA fiber crosslinking with PEGDE

Meng

Zhu

et al. 2018

J of Applied Polymer Sci

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Modified sodium alginate (mSA) fiber is prepared through the wet spinning process using poly(ethylene glycol) diglycidyl ether (PEGDE, the molecular weight of PEGDE is 400) as the crosslinking agent to improve the mechanical and hygroscopic properties. Flowing property of the spinning solution and properties of the mSA fiber are characterized by DV-C digital viscometer, single fiber electronic tensile strength tester and other instruments. Results show that viscosity of the spinning solution dropped firstly, then increased and decreased lastly with increasing PEGDE content in mSA fiber. The optimal value of the tensile strength of mSA fiber is 2.47 cN/dtex increasing by 64.67% compared to pure SA fiber. Both the crosslinking degree and crystallinity of mSA fiber rise first and then descended with the increase of PEGDE content. The hydroscopicity of mSA fiber increase from 30.5% to 70.9% at 20 wt % PEGDE in mSA fiber.

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Section: Introductionmentioning

confidence: 99%

Improvement in mechanical and hygroscopic properties of modified SA fiber crosslinking with PEGDE

Meng

Zhu

et al. 2018

J of Applied Polymer Sci

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“…Other polymers were also used as carrier polymers for facilitating the spinnability of alginate [57,58]. Polylactic acid (PLA) as the continuous phase and sodium alginate as the dispersion phase were used by Xu et al [59] to prepare a W/O emulsion and then electrospun into nanofibrous membrane for tissue engineering.…”

Section: Other Polymersmentioning

confidence: 99%

“…The resulting blend exhibited excellent mechanical properties with tensile strength increasing from 0.25 to 3.13 MPa. Elsewhere, electrospun nanofibers composed of poly (lactic-co-glycolic acid) (PGLA) and ciprofloxacin-loaded alginate were fabricated by using the classical single needle electrospinning technique [58]. In this regard, alginate was spray dried in order to produce particles with sizes ranging between 100 nm and 15 µm and suspended into chloroform; then, it was introduced into PLGA-trifluoroethanol solution.…”

Section: Other Polymersmentioning

confidence: 99%

“…The fabrication of multifunctional nanofibrous materials that have different chemical, physical, and mechanical properties by incorporating other components offers the opportunity to develop advanced products for medical applications [49,52]. Due to its low cost, low toxicity, biocompatibility, and biodegradability, alginate has been extensively studied for biomedical application [58,62,68].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Moreover, bioactive substances can be incorporated to produce multifunctional products that can further promote wound healing [70]. PLGA/sodium alginate (SA) loaded with ciprofloxacin (antibiotic) for wound dressing was prepared by Liu et al [58]. Sodium alginate enhanced the hydrophilicity of the samples from approximately 111.7 • to 97.3 • and with excellent mechanical properties with its Young's modulus being close to that of human skin (i.e., tensile strength and modulus of about 60-70 MPa and 17-21 MPa, respectively).…”

Section: Wound Dressingmentioning

confidence: 99%

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Electrospun Alginate Nanofibers Toward Various Applications: A Review

et al. 2020

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Alginate has been a material of choice for a spectrum of applications, ranging from metal adsorption to wound dressing. Electrospinning has added a new dimension to polymeric materials, including alginate, which can be processed to their nanosize levels in order to afford unique nanostructured materials with fascinating properties. The resulting nanostructured materials often feature high porosity, stability, permeability, and a large surface-to-volume ratio. In the present review, recent trends on electrospun alginate nanofibers from over the past 10 years toward advanced applications are discussed. The application of electrospun alginate nanofibers in various fields such as bioremediation, scaffolds for skin tissue engineering, drug delivery, and sensors are also elucidated.

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Alginate-Based Interpenetrating Network Carriers for Biomedical Applications

Das

Subuddhi

2020

Interpenetrating Polymer Network: Biomedical Applications

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The development of an alginate/polycaprolactone composite scaffold for in situ transfection application

Cited by 45 publications

References 26 publications

Improvement in mechanical and hygroscopic properties of modified SA fiber crosslinking with PEGDE

Improvement in mechanical and hygroscopic properties of modified SA fiber crosslinking with PEGDE

Electrospun Alginate Nanofibers Toward Various Applications: A Review

Alginate-Based Interpenetrating Network Carriers for Biomedical Applications

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