The development of anticancer agent releasing microcapsule made of ferromagnetic amorphous flakes for intratissue hyperthermia

Preparation of Silica‐Coated Lanthanum–Strontium Manganite Particles with Designable Curie Point, for Application in Hyperthermia Treatments

“…Although manganites have not yet been used in hyperthermia or any other biomedical treatments, many different materials, exhibiting relatively low T c , including Cu–Ni, 12,13 Pd–Ni, 14,15 Fe–Pt, 16 Pd–Co, 17,18 and Ni–Si 19 alloys, Co 1− x Zn x Fe 2 O 4 , 20 Y 3 Fe 5− x Al x O 12 , 20 Fe 66 P 13 C 7 Cr 14 amorphous flakes 21 , and others have been used, albeit in the majority of cases as stationary, interstitial implants. It has been shown that successful in vivo attachment of magnetic particles is—in certain cases of larger entities, such as cells—not limited to nano‐sized particles, but could be even more significant when micrometer or submicrometer sized magnetic particles are used, 1 depending largely on the tissue or the organ concerned 22 . Whereas it is said that extracellular maneuvers are limited to particles less than 50 nm in size 23 (with natural, ferritin particles being 9 nm in diameter and diffusing rapidly through intercellular space 3 ), micrometer sized particles (wherein, even though the smallest capillaries in the body are 5–6 μm in diameter, 22 particles as large as 200 μm on average were successfully applied 21,24 ) are better suited to withstand the flow dynamics in the circulatory system 1 . Particles of moderate size range (∼200 nm), 25 such as the ones prepared within this work, might therefore be optimally suited for the promotion of in vivo drug‐targeting effects.…”

Metallic Colloid Nanotechnology, Applications in Diagnosis and Therapeutics

“…Even if, as we have seen, some authors have claimed to achieve intracellular hyperthermia, various uncertainties in their work did not allow making the distinction between the hyperthermic efficiency due to intra and extracellular particles [167,174]. However the idea of an intracellular hyperthermia is fascinating because it implies both the specific targeting of the cancer cells and a more direct damage of the heating on their vital structures, see Fig.…”

“…Experiments carried out on model tumors in rabbits or pigs, with the kidney as target organ, have demonstrated that arterial embolization is indeed useful to selectively and efficiently heat the targeted tissue (> 42°C, for several minutes), even in a well blood-supplied, deep localized mass [171][172][173]. Additionally, the magnetic microparticles used for the embolization may be loaded with an anticancer drug, so that a synergistic effect between the hyperthermia and the contemporary local release of the chemotherapeutic agent was obtained [174].…”

On the energy transfer between the electromagnetic field and nanomachines for biological applications

“…In particular, due to their reduced size, the use of remotely activated multifunctional NMs can improve medical imaging techniques [Louis et al, 1993;Ito et al, 2005] as well as revolutionize therapeutic approaches, making drug delivery a real opportunity to hit sick targets, even with cellular dimensions, and preserve neighbouring healthy tissues [Sato et al, 1993;Deng et al, 2003; La Van et al, 2003]. …”