The Development of Antifertility Substances

Jackson, H.

doi:10.1007/978-3-0348-7053-5_3

Cited by 11 publications

(18 citation statements)

References 171 publications

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“…Linkage map, 11 Lipopolysaccharide, 274, 280 Litter size, 547, 554 Liver, [89][90][91]94,99,108,122,140,418 poison,577 LSD,575 Lung,94 Lymphocyte,380,[525][526][527]416,420,421 Ly~~ 12~ 15~ 175,196,197,229,291 immunity to,238 Lysogeny,21,20,122,152,196,197,231 Macrophage,401,402 Magdala red,293,305 Magnesium acetate,123 Magnesium ions,123 Magnesium sulfate,208 Maize, see Corn MAK, see Methylated serum albumin kieselguhr column Malate dehydrogenase, 603 lix Maleic hydrazide (MH), 45,61,359,360,378,493,494,495,498,560 MAM,…”

Section: Chaptermentioning

confidence: 99%

“…Prenatal death, as indicated Chlorambucil (4-[p-(bis[2-chloroethyl] 30,32,33,47,48,28,72,80,90,111,128 :I: 88, 122 124, 175, 172,176, 185-198 199-201 : ... by reduced fertility, decreased litter size, and increased resorption, does not of itself prove teratogenicity, since deformity and lethality may be uncorrelated (1)(2)(3) and due to different mechanisms. Mutations are changes in the genetic material.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Mutagens

1971

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Section: Chaptermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Mutagens

1971

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“…Of special interest are pharmacological agents which interfere with selective repro¬ ductive processes and yet are reversible in their effects and relatively free of systemic toxicity. Although there exists an appreciable number of compounds capable of interfering with mammalian fertility (Jackson, 1964), very few, with the exception of certain steroidal compounds, have been of value in studying such problems. In spite of this inadequacy the number of new com¬ pounds added to this list since previous reviews (Henshaw, 1953;Parkes, 1953;Jackson, 1959) has been minimal.…”

Section: Introductionmentioning

confidence: 99%

The Inhibition of Pregnancy With an Oxazolidinethione (U-11634)

Duncan¹,

Johnston²,

Lyster³

1966

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U-11634 effectively inhibits pregnancy in rats and mice following either parenteral or oral administration. A single dose administered to rats on Day 4 was as effective as treatment for the first 7 days of pregnancy; however, a single dose on other days of pregnancy was not effective. Pregnancy could not be inhibited in hamsters. At therapeutic doses this compound did not exhibit uterotrophic, anti-oestrogenic, androgenic, gonadotrophic-inhibiting, blastolytic or foetal toxicity activities.Deciduomata formation in rats was inhibited by the compound. This effect was not reversed by progesterone or oestradiol administered simultaneously with U-11634 in ovariectomized, pseudopregnant rats with traumatized uterine horns. Inhibition of nidatory processes may be involved in the observed anti-fertility efficacy. The effects and the unique biological spectrum of this compound relative to other inhibitors of implantation are discussed.

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“…It was already well known at that time that certain chemical compounds produce teratogenic effects in experimental animals (Murphy, Dagg & Karnofsky, 1957;Sokal & Lessman, 1960;Barker, 1960): it had also been well established that the time, route, dose and duration of exposure of a substance could be important in determining its teratogenic effect (Jackson, 1959). However, before 1961 no-one appears to have screened new chemical compounds routinely as a part of safety evaluation prior to their clinical use, although techniques available at that time were probably adequate for screening procedures to have been carried out.…”

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confidence: 99%