The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome

Abstract

We report a case of cerebral venous thrombosis related to the ingestion of tadalafil. A 45-year-old man presented with posterior headache and was diagnosed with tension headache. Five days later, he was transported to our hospital via ambulance due to a tonic-clonic seizure. Head MRI showed cerebral venous thrombosis (CVT). He confessed to having recently taken a large doses of tadalafil. His anti-cardiolipin antibody and anti-caldiolipin-β2-glycoprotein-I complex antibody levels were elevated. Our case suggests the possibility that tadalafil is related to both cardiovascular complications and CVT in patients with hypercoagulability. Patients with conditions associated with hypercoagulability, including antiphospholipid syndrome may be better advised to avoid the use of tadalafil.

Lupus, antiphospholipid syndrome, and stroke: An attempt to crossmatch

“…Shlebak 128 IgG Transverse sinus, sigmoid sinus Warfarin Shlebak 128 IgG Transverse sinus Warfarin Behrendt et al 129 IgM and IgG Superior sagittal sinus, right transverse sinus Warfarin, venticuloperitoneal shunt Pelegrina Molina et al 130 IgG Superior sagittal sinus, right transverse sinus Warfarin, corticosteroids Nagai et al 131 Unspecified Superior sagittal sinus, cortical vein Corticosteroids Miki et al 132 Unspecified Straight sinus Anticoagulation Ikejiri et al 133 IgG Right transverse sinus NR Numata et al 134 Unspecified Cortical vein Therapeutic heparin Hsieh et al 135 IgM Superior sagittal sinus, right transverse sinus Warfarin, corticosteroids Sakamoto et al 136 Unspecified Superior sagittal sinus Warfarin brain small vessels leading to inflammatory vascular occlusion. 79 Despite that SLE is characterized by low complement levels, elevated complement levels were associated with stroke.…”