The development of COVID-19 treatment

Yuan, Yanggang; Jiao, Baihai; Qu, Lili; Yang, Duomeng; Liu, Ruijuan

doi:10.3389/fimmu.2023.1125246

Cited by 124 publications

(94 citation statements)

References 190 publications

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“…Over the last few years, several therapeutic strategies have been investigated. 81 Remdesivir (GS-5734), a broad-spectrum antiviral agent, received emergency use authorization (EUA) from the FDA as it was the first antiviral agent to be tested against COVID-19 and showed initial success at inhibition of SARS-CoV-2 in primary human lung cell lines. 82 Clinical trials have also shown a reduction in recovery times and reduced all-cause mortality.…”

Section: Sars-cov-2 and Covid-19-related Alimentioning

confidence: 99%

Exploring m6A‐RNA methylation as a potential therapeutic strategy for acute lung injury and acute respiratory distress syndrome

Faraj

Liang

et al. 2023

Pulm. circ.

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N6‐methyladenosine (m6A) is the most common methylation modification in mammalian messenger RNA (mRNA) and noncoding RNAs. m6A modification plays a role in the regulation of gene expression and deregulation of m6A methylation has been implicated in many human diseases. Recent publications suggest that exploitation of this methylation process may possess utility against acute lung injury (ALI). ALI and its more severe form, acute respiratory distress syndrome (ARDS) are acute, inflammatory clinical syndromes characterized by poor oxygenation and diffuse pulmonary infiltrates. This syndrome is associated with microvascular endothelial dysfunction, subsequent pulmonary hypertension and may ultimately lead to mortality without rigorous and acute clinical intervention. Over the years, many attempts have been made to detect novel therapeutic avenues for research without much success. The urgency for the discovery of novel therapeutic agents has become more pronounced recently given the current pandemic infection of coronavirus disease 2019 (COVID‐2019), still ongoing at the time that this review is being written. We review the current landscape of literature regarding ALI and ARDS etiology, pathophysiology, and therapeutics and present a potential role of m6A methylation. Additionally, we will establish the axiomatic principles of m6A methylation to provide a framework. In conclusion, METTL3, or methyltransferase‐like 3, the selective RNA methyltransferase for m6A, is a hub of proinflammatory gene expression regulation in ALI, and using a modern drug discovery strategy will identify new and effective ALI drug candidates targeting METTTL3.

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Section: Sars-cov-2 and Covid-19-related Alimentioning

confidence: 99%

Exploring m6A‐RNA methylation as a potential therapeutic strategy for acute lung injury and acute respiratory distress syndrome

Faraj

Liang

et al. 2023

Pulm. circ.

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“…At the same time, Fangcang hospitals have been set up in some (Li et al, 2023), the safety of these drugs for children has not been confirmed, so they are all not approved for use to children (Yuan et al, 2023). Only one drug is currently recommended for antiviral treatment with ambavirizumab/lomivirizumab injection for students aged 12-17 years who have mild to moderate cases with high-risk factors for progression to severe disease.…”

Section: Treatment and Care Of Infected Studentsmentioning

confidence: 99%

Characteristic analysis of China's actions against the COVID‐19 in schools and comparison with other countries

Li,

2023

Public Health Nursing

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BackgroundThe outbreak of the COVID‐19 poses a great threat to students globally. China has taken steps to keep students from becoming infected for more than 30 months, while other countries have also taken steps. Comparing the intentions, implementation, immediate and long‐term effects of these initiatives can shed more light on the care of adolescents in schools.ObjectiveThe focus of the study is to describe the full range of school prevention measures in China, identifying when they work and when they do not. At the same time, some typical measures taken in other countries’ schools are presented and compared to provide a comprehensive discussion.MethodsThis study attempted to combine data comparison, information analysis, policy interpretation, and participatory observation to form a comprehensive analytical network.ResultsChina's schools have gone through of lucky periods, safety periods, difficult periods, and crisis periods. These efforts are due to the government's intense control measures, strict accountability of school administrators, frequent nucleic acid testing, widespread vaccination, and widely implemented online learning. In comparison, the measures taken by China are difficult to implement, and the price paid by the government, schools and students needs to be further assessed and reflected upon.ConclusionsThe virus is able to destroy the school's defence with ease. There should be a consensus among countries for a permanent virus control strategy, but the severity of the various measures needs to be appropriately determined, strict control measures can also have negative effects.

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“…By April 8, 2023, Coronavirus disease‐2019 (COVID‐19) has caused more than 684 million infections and 6.83 million deaths worldwide 1 . Despite the widespread application of pharmacological interventions such as antiviral drugs and monoclonal antibodies, 2 patients were still affected by SARS‐COV‐2 infection physically and mentally both in the acute stage and post‐COVID‐19 condition, which was defined as 3 months from the onset of COVID‐19 with symptoms that last for at least 2 months 3,4 . Thus, new strategies are paramount and urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Can inspiratory muscle training benefit patients with COVID‐19? A systematic review and meta‐analysis

Chen,

Liu,

Tong

2023

Journal of Medical Virology

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The possible benefits of inspiratory muscle training (IMT) on mechanical and clinical outcomes in patients with Coronavirus disease‐2019 (COVID‐19) remain controversial. We conducted a meta‐analysis to evaluate the effect of IMT in the rehabilitation strategy of patients with COVID‐19. The Pubmed, Embase, Web of Science (WOS), and Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify trials evaluating the efficacy of IMT in the treatment of patients with COVID‐19. The primary outcome included change from baseline of VO2max, maximal inspiratory pressure (PImax), 6‐min walk test(6MWT), forced expiratory volume in the first second predicted (FEV1%pred), and quality of life (QOL). Six studies with 349 participants were analyzed. Significant improvements were found in change from baseline of VO2max (MD: 4.54, 95% confidence interval [CI]: 1.79–7.30, Z = 3. 32, I2 = 0, p = 0.001), PImax (MD: 21.43, 95% CI: 1.33–41.52, Z = 2.09, I2 = 90%, p = 0.04), 6MWD (MD: 40.13, 95% CI: 24.92–55.35, Z = 5.17, I2 = 0, p < 0.00001) and FEV1%pred (MD: 8.73, 95% CI 3.07–14.39, Z = 3.02, p = 0.002) while no statistical improvements were found in QOL (SMD: 0.70, 95% CI: 0.37–1.03, Z = 4.15, I2 = 89% p = 0.32) between IMT group and control group. The application of IMT might elicit mechanical and clinical improvement in patients with COVID‐19. IMT could be recommended as an effective strategy of pulmonary rehabilitation for COVID‐19. However, the proper timing, optimal duration, as well as appropriate frequency and intensity of IMT remain uncertain and further studies are needed.

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The development of COVID-19 treatment

Cited by 124 publications

References 190 publications

Exploring m6A‐RNA methylation as a potential therapeutic strategy for acute lung injury and acute respiratory distress syndrome

Exploring m6A‐RNA methylation as a potential therapeutic strategy for acute lung injury and acute respiratory distress syndrome

Characteristic analysis of China's actions against the COVID‐19 in schools and comparison with other countries

Can inspiratory muscle training benefit patients with COVID‐19? A systematic review and meta‐analysis

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