The Development of Diabetic Retinopathy: Effects of Duration and Control of Diabetes

Hardin, Robert C.; Jackson, Robert L.; Johnston, Theodore L; Kelly, Helen G.

doi:10.2337/diab.5.5.397

Cited by 62 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17 However, other studies found no relationship between the level of glycaemia and the incidence of retinopathy. '8 '9 Our findings support the view that the severity of diabetes and the degree of hyperglycaemia influence susceptibility to the development of retinopathy and its severity.…”

Section: Discussionmentioning

confidence: 96%

Prevalence and 15-year incidence of retinopathy and associated characteristics in middle-aged and elderly diabetic men.

Yanko¹,

Goldbourt²,

Michaelson³

et al. 1983

British Journal of Ophthalmology

View full text Add to dashboard Cite

SUMMARY We examined 178 men for the presence of diabetic retinopathy during 1978-80. They had been part of a group of 205 men from the Jerusalem area, diagnosed as being diabetic or having an abnormal glucose tolerance test in the Israel Ischaemic Heart Disease Project, a 5-year epidemiological investigation of Israeli male government employees. Seventy-four (42%) had diabetic retinopathy as determined by direct and indirect ophthalmoscopy, 3-mirror contact lens examination, and fundus photography. Those with and without retinopathy were compared for clinical, biochemical, behavioural, and biographical variables measured subsequently in 1963, 1965, and 1968. We found no significant differences between the 2 groups with respect to antecedent Quetelet index, blood pressure, peripheral vascular disease, blood lipids, haematocrits, smoking habits, area of birth, and education. Statistically significant differences between men with and without retinopathy were found for severity of carbohydrate metabolic intolerance at identification, duration of the metabolic abnormality, age, casual glucose values, and serum uric acid levels. Low serum uric acid appears to precede the incidence of diabetic retinopathy and to decline further as the disease progresses.

show abstract

Section: Discussionmentioning

confidence: 96%

Prevalence and 15-year incidence of retinopathy and associated characteristics in middle-aged and elderly diabetic men.

Yanko¹,

Goldbourt²,

Michaelson³

et al. 1983

British Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…During the last three decades many clinical investigations have been undertaken in various parts of the world to determine if the incidence of microangiopathy is related to the degree of control of the diabetes [46]. With only a few exceptions [47] these studies have indicated that microvascular disease is less common in well controlled diabetics than in those in whom a less careful regimen of therapy is maintained [48][49][50][51][52]. Perhaps foremost in these clinical assessments is the ambitious longterm prospective study of Pirart and his collaborators [52] which has shown that diabetic capillary disease is closely related to the degree of glycemic control.…”

Section: Metabolic Hypothesis Of Diabetic Microangiopathymentioning

confidence: 99%

Search for a biochemical basis of diabetic microangiopathy

1976

Diabetologia

191

View full text Add to dashboard Cite

Summary. Diabetic microangiopathy, particularly as seen in the renal glomerulus, is characterized by morphological and biochemical alterations of the capillary basement membrane. Observations from a number of disciplines have indicated that the microvascular disease is not a separately inherited entity but a true consequence or "complication" of insulin deficiency. An evaluation of the biochemical events which could be responsible for the basement membrane lesions of diabetes indicates that the hyperglycemia or plasma somatotropin elevation of this disease alone, or in combination, may play an important role.

show abstract

“…This is at variance with a number of other reports 4 ' 21 " 22 where the duration of known diabetes has been related to the appearance of vascular disease. Other reports from such Centers as the Joslin Clinic, 19 Toronto Sick Children's Hospital, 24 University of Iowa, 34 and Karolinska Institute of Stockholm 1 indicate a higher prevalence of vascular disease in young diabetic patients. These latter studies are not comparable, however, for the age at diagnosis of diabetes was less than twenty years, and the duration of diabetes often more than ten years.…”

Section: Discussionmentioning

confidence: 94%

Interrelationship of Vascular Disease and Blood Lipids in Young Indian Diabetics

et al. 1969

View full text Add to dashboard Cite

Clinical and laboratory data on 100 young diabetic patients in a North Indian urban population were obtained to determine the prevalence of vascular disease and its relation to certain clinical factors. The findings revealed evidence of vascular disease in 32 per cent of young diabetics as retinopathy (15.0 per cent), coronary artery disease (myocardial infarction and angina pectoris, 14 per cent) and nephropathy (10 per cent). Duration of disease, dietary habits, or the mode of treatment and control of diabetes did not appear to be related to the development of vascular disease. Total serum lipid content and triglycerides were elevated in those who manifested clinically objective vascular disease.

show abstract

The Development of Diabetic Retinopathy: Effects of Duration and Control of Diabetes

Cited by 62 publications

References 0 publications

Prevalence and 15-year incidence of retinopathy and associated characteristics in middle-aged and elderly diabetic men.

Prevalence and 15-year incidence of retinopathy and associated characteristics in middle-aged and elderly diabetic men.

Search for a biochemical basis of diabetic microangiopathy

Interrelationship of Vascular Disease and Blood Lipids in Young Indian Diabetics

Contact Info

Product

Resources

About