The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983

Murphy, P. J.

doi:10.1124/dmd.108.021113

Cited by 5 publications

(2 citation statements)

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“…The year 2008 was memorable for ASPET and centennial perspectives articles focused on drug metabolism research included discussion of historical landmarks in the discovery of "MC-type" induction and the early characterization of the AHR system (Murphy, 2008a) and the continuing evolution of the AHR field into the realm of endogenous ligands (Murphy, 2008b). Perspectives from the Pharmaceutical Research and Manufacturers of America included surveys of current practices for in vitro assays of P450 inducers acting via the AHR and clinical drug-drug interaction studies involving CYP1A2 induction (Bjornsson et al, 2003;Chu et al, 2009).…”

Section: The 2000smentioning

confidence: 99%

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

Riddick

2023

Drug Metab Dispos

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The induction of multiple drug-metabolizing enzymes by halogenated and polycyclic aromatic hydrocarbon toxicants is mediated by the aryl hydrocarbons receptor (AHR). This fascinating receptor also has natural dietary and endogenous ligands, and much is now appreciated about the AHR's developmental and physiological roles, as well as its importance in cancer and other diseases. The past several years has witnessed increasing emphasis on understanding the multifaceted roles of the AHR in the immune system. Most would agree that the "discovery" of the AHR occurred in 1976, with the report of specific binding of a high affinity radioligand in mouse liver, just three years after the launch of the journal Drug Metabolism and Disposition (DMD) in 1973. Over the ensuing fifty years, the AHR and DMD have led parallel and often intersecting lives. The overall goal of this minireview is to provide a decade-by-decade overview of major historical landmark discoveries in the AHR field and to highlight the numerous contributions made by publications appearing in the pages of DMD. It is hoped that this historical tour might inspire current and future research in the AHR field. Significance Statement With the launch of Drug Metabolism and Disposition (DMD) in 1973 and the discovery of the aryl hydrocarbon receptor (AHR) in 1976, the journal and the receptor have led parallel and often intersecting lives over the past fifty years. Tracing the history of the AHR can reveal how knowledge in the field has evolved to the present and highlight the important contributions made by discoveries reported in DMD. This may inspire additional DMD papers reporting future AHR landmark discoveries.

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Section: The 2000smentioning

confidence: 99%

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

Riddick

2023

Drug Metab Dispos

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“…These changes helped the bottom line and reduced the time from acceptance to publication. In 2008 we celebrated the ASPET centennial year, and Dr. Pat Murphy (Murphy, 2008a;Murphy, 2008b;Murphy, 2008c) Many pharmaceutical companies assembled large databases for all the compounds they generated and began to use these databases to develop predictive programs for structure and function. As the structures of many of these compounds had not been disclosed, these studies could not be published in ASPET due to a mandate that the structure of any new compound needed to be reported so that others could replicate the reported findings.…”

Section: More Good Timingmentioning

confidence: 99%

The Evolution ofDrug Metabolism and Disposition: A Perspective From the Editors

et al. 2022

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This article was solicited to commemorate the 50 th anniversary of Drug Metabolism and Disposition (DMD) and features perspectives from five former Editors spanning the years 1994 to 2020. During that time frame the journal underwent significant changes in manuscript submission and processing as well as multiple generational changes in the composition of the Editorial Board and Associate Editors. A constant, however, has been the commitment to be the premier journal for publications of articles in the areas of drug metabolism, absorption, distribution, excretion, and pharmacokinetics. Advances in some of those areas during the past three decades have been monumental. Two cases in point involve cytochromes P450 and drug transporters.In 1994 rigorous characterization of human cytochrome P450 enzymes was in its infancy, there were no proven selective inhibitors, and the idea of a solving a human P450 X-ray crystal structure was just a fantasy. Likewise, little was known about individual drug transporters. Today, detailed knowledge of individual human P450 enzymes and drug transporters is integral in drug design and drug discovery and in avoiding drug interactions. In the face of these huge advances in knowledge, each Editor has been charged with maintaining the caliber and significance of the journal and its financial solvency, while serving the needs of individual authors. We present five individual perspectives on the challenges and rewards of serving as DMD Editor and hope that by humanizing the job, we will encourage others to assume positions of responsibility in publication of society journals.

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A Personal and Historical Perspective on Drug Metabolism

Miwa

Cho

2014

Handbook of Metabolic Pathways of Xenobiotics

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The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983

Cited by 5 publications

References 50 publications

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

The Evolution ofDrug Metabolism and Disposition: A Perspective From the Editors

A Personal and Historical Perspective on Drug Metabolism

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