The development of endometriosis in a murine model is dependent on the presence of dendritic cells

Pencovich, Niv; Luk, Janelle; Hantisteanu, Shay; Hornstein, Mark D.; Fainaru, Ofer

doi:10.1016/j.rbmo.2013.12.011

Cited by 37 publications

(23 citation statements)

References 35 publications

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“…Pencovich et al . demonstrated that endometriotic lesion formation was reduced in their dendritic‐cell depleted mice; however, Stanic et al . reported that depletion resulted in greater lesion size .…”

Section: Introductionmentioning

confidence: 93%

“…44 Interestingly, two studies that followed using CD11c-DTR-GFP transgenic mice, whereby the dendritic cells are temporarily depleted using diphtheria toxin injection, 45 generated contradictory results. Pencovich et al demonstrated that endometriotic lesion formation was reduced in their dendritic-cell depleted mice 46 ; however, Stanic et al reported that depletion resulted in greater lesion size. 47 The study protocol, especially the timing of diphtheria toxin injection (depleting dendritic cells), may account for the difference in outcomes.…”

Section: Animal Studies Using Endometriosis Mouse Modelsmentioning

confidence: 99%

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Involvement of immune cells in the pathogenesis of endometriosis

Izumi

Koga

Takamura

et al. 2018

J of Obstet and Gynaecol

141

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Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation; however, retrograde menstruation occurs in almost all women and other factors are required for the establishment of endometriosis, such as cell survival, cell invasion, angiogenesis, and cell growth. Immune factors in the local environment may, therefore, contribute to the formation and progression of endometriosis. Current evidence supports the involvement of immune cells in the pathogenesis of endometriosis. Peritoneal neutrophils and macrophages secrete biochemical factors that help endometriotic cell growth and invasion, and angiogenesis. Peritoneal macrophages and NK cells in endometriosis have limited capability of eliminating endometrial cells in the peritoneal cavity. An imbalance of T cell subsets leads to aberrant cytokine secretions and inflammation that results in the growth of endometriosis lesions. It is still uncertain whether these immune cells have a role in the initial cause and/or stimulate actions that enhance disease; however, in either case, modulating the actions of these cells may prevent initiation or disease progression. Further studies are needed to deepen the understanding of the pathology of endometriosis and to develop novel management approaches of benefit to women suffering from this disease.

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Section: Introductionmentioning

confidence: 93%

Section: Animal Studies Using Endometriosis Mouse Modelsmentioning

confidence: 99%

Involvement of immune cells in the pathogenesis of endometriosis

Izumi

Koga

Takamura

et al. 2018

J of Obstet and Gynaecol

141

View full text Add to dashboard Cite

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“…In mouse models DCs have been shown to be important in the development of endometriosis. In humans the role of DCs in endometriosis is largely unknown (Pencovich et al 2014, Stanic et al 2014. Fainaru et al (2012) described in one case an unilateral endometrioma which was associated with complete absence of DCs, contrary to a follicle of the contralateral ovary, where an abundance of DCs was seen.…”

Section: Dendritic Cells In Ff Of Patients With Endometriosismentioning

confidence: 99%

Is there an immune modulating role for follicular fluid in endometriosis? A narrative review

et al. 2020

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Follicular fluid (FF) surrounds the granulosa cell–oocyte complex and is one of the mediating factors in the communication between the cells within the follicle. Literature reveals that human FF and its components are key factors to the success of natural fertilization. Among other substances, FF consists of multiple cytokines and immune cells, including interleukin 6 (IL6), IL12, sHLA-G, macrophages, NK cells and lymphocytes. Together, these cells and cytokines might influence the oocyte–granulosa–cell complex. Altered balances of immune content might be involved in changes on folliculogenesis, oocyte maturation, oocyte quality and ovulation. Furthermore, these altered balances are possibly involved in infertility associated with immune-mediated diseases such as endometriosis. The aim of this narrative review is to elaborate on the function and contents of FF and its immunological profile in patients with endometriosis. A comprehensive literature search was performed for the published literature on FF (immune) contents, FF function and FF content alterations in endometriosis patients. In FF of patients with endometriosis, elevated levels of macrophages and several cytokines have been reported. The role of specific immune cells in FF and a clarification of the biological mechanism in healthy women and endometriosis patients remain largely unknown. Future studies in this field will give us more insight in the role of FF immune cells and the effect of altered balances in patients with endometriosis.

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“…A second mechanism occurs via the reduction in the phagocytic abilities of macrophages and natural killer cells, thus inhibiting the clearance of endometrial cells in the immediate environment of lesions (Chuang et al 2010). In a murine model of ENDO, EC growth was associated with dendritic cells, which can attenuate (Stanic et al 2014) or enhance (Pencovich et al 2014) the process. Toll-like receptors (TLRs) are essential components of the innate immune system owing to their roles in mediating pattern recognition of and response toward pathogens and hostrelated antigens.…”

Section: Commonalities Between T1dm and Endo Inflammatory Statusmentioning

confidence: 99%

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Simmen

Brown

Quick

et al. 2019

Journal of Endocrinology

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Type 1 diabetes mellitus and endometriosis separately affect millions of women worldwide. Reproductive-age women diagnosed with type 1 diabetes may also suffer from endometriosis, but the asymptomatic pre-clinical period of highly variable duration for each condition can lead to challenges in the timely recognition of co-morbid disease onset and misdiagnosis. While knowledge of the pathogenesis of each condition has grown substantially, co-morbid endometriosis and type 1 diabetes has not been widely considered and much less addressed. This review discusses the molecular rationale for the likelihood of their co-existence, and prospects for improvements in therapeutic strategies and reduced complications, if this paradigm is included as a significant variable in disease management.

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The development of endometriosis in a murine model is dependent on the presence of dendritic cells

Cited by 37 publications

References 35 publications

Involvement of immune cells in the pathogenesis of endometriosis

Involvement of immune cells in the pathogenesis of endometriosis

Is there an immune modulating role for follicular fluid in endometriosis? A narrative review

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

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