The current socio-economic situation in the country and in the world places ever-higher demands on the professionalism of a person: a constant change in the nature and goals of work occurs, new professions arise, and the intensity and tension of work increases. The employee is required high professionalism, personal competitiveness, increased responsibility, the ability to work in conditions of economic and psychological uncertainty. The formation of professional suitability and competence of such a professional is impossible without reliance on the psychological qualities of a person. In this regard, the role of targeted career guidance work in the educational system has sharply increased, which should be based on a thorough knowledge of the entire system of the main factors that determine the future professional suitability of a specialist, including psychological ones. The article considers the psychological aspects of the professional suitability of students receiving higher education. On the basis of an empirical study, which was attended by 120 junior students receiving higher education in economics and finance, it is concluded that the professional inclinations and orientation, motivation for choosing a profession for the majority of students who took part in the study correspond to the choice of profession. At the same time, a certain part of students has been identified whose professional inclinations and motivation do not yet sufficiently correspond to the direction of study, and therefore this group requires in-depth psychological and pedagogical work in a higher educational institution. The article highlights the experience of the Russian regional university in building a career guidance system, shaping professional suitability and enhancing professional selfdetermination of student youth.