The development of novel calcium phosphate–polymer composite biomaterials with macro- to nano-level controlled hierarchical structures

Yokoi, Taishi

doi:10.2109/jcersj2.19095

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…Those composites were found to promote bone growth due to the balanced cellular activity of osteoblasts and osteoclasts [473]. There is also an excellent review on OCP/polymer biocomposites with a controlled hierarchical structure from the macro to the nanoscale [474]. The following topical overview contains more details about OCP-based formulations that are relevant to biomedicine [475].…”

Section: Biocomposites With Remaining Capomentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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Section: Biocomposites With Remaining Capomentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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“…At present, seed cells can be divided into stem cells, bone cells, fibroblasts, and endothelial cells [19]. Mesenchymal stem cells have the potential to differentiate into bone and adipose tissue.…”

Section: Seed Cells and Growth Factorsmentioning

confidence: 99%

“…Chitosan, collagen, and fibrin are more commonly used in natural biomaterials. ese materials have no toxic and side effects, can help cells better adhere to, proliferate, and differentiate, and can also fight infection and promote the recovery of immune function [19]. But it has a certain degree of immunogenicity, and the degradation rate is not very stable.…”

Section: Support Materialmentioning

confidence: 99%

Compatibility of Composite Biomaterials in Sports Injury Repair

Xing

2021

Advances in Materials Science and Engineering

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With the rapid development of sports, sports injuries have become an inevitable problem in sports. Repairing sports injuries has always been the focus of attention in the field of sports and medicine. The wide application of biomedical materials leads to the innovation and development of medical technology. It is of great significance to use them to repair sports injuries, but the current research results are not ideal. In this paper, the biocompatibility of composite biomaterials used to repair sports injuries was studied. First, the rat bone marrow mesenchymal stem cells were cultured to prepare a cell suspension. Then, the tricalcium phosphate-gelatin composite scaffold material and the collagen material were scraped into powder to make the material extract, which are, respectively, the experimental group and the control group. An apoptosis detection kit and a flow cytometer were used to detect apoptosis rate and survival rate of all samples, and a CKK-8 kit was used to detect cytotoxicity and calculate cell proliferation activity. The absorbance value was read with a microplate reader, and the coagulation performance and hemolysis rate of different groups were calculated. The experimental results showed that the cell survival rate of the experimental group was 91.41%, the early apoptosis rate was 2.81%, the stem cell proliferation activity was 0.83, and the anticoagulant performance and hemolysis rate were 64.8% and 0.28%, respectively. This indicates that although the anticoagulant performance of the tricalcium phosphate-gelatin composite scaffold is weak, its cell proliferation activity is strong, which is more suitable for cell adhesion and proliferation, and the cell apoptosis and hemolysis rate are lower. Therefore, it has better biocompatibility than a single collagen material.

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