The Development of Phyto- and Tissue Origin Medicines for Veterinary Reproductive Issues

Abstract

Modern conditions of practical veterinary medicine require the use of effective and safe drugs. Along with the already known and common medicines, the search for new drugs which are harmless for the body and have the physiological direction of action is still required. In recent years, the attention to the use of phyto- and tissue-derived drugs increased. However, the problem of their use is insufficiently studied – many aspects of their clinical use require further development, expansion of the spectrum of used medicinal plants, study, and implementation into veterinary practice. Therefore, the purpose of this work was to develop a comprehensive vitamin-hormone drugs based on phyto- and tissue medicines for the treatment and prevention of reproductive abnormalities in animals. Based on the information on the etiopathogenesis of disorders of reproductive function indicators: homeostasis, reducing of the concentration of hormones (estrogen or progesterone), changes in the morphofunctional state of endocrine (pituitary, thyroid, and adrenal gland) and reproductive (ovaries) organs, the application of vitamin-hormone drugs in veterinary medicine is scientifically sound. Drugs in terms of pathogenetic therapy can optimise homeostasis, hormone concentrations, stimulate rehabilitation processes in the regulatory organs of reproductive function (pituitary, adrenal, and thyroid) and reproductive organs (ovaries), which, in turn, contributes to the normalisation of follicles which are a prerequisite for the full reproductive capacity of females. Vitamin-hormonal medicines of herbal and tissue origin were developed, with high efficiency for the treatment and prevention of reproductive pathologies of various species of animals, providing the stimulation of reproductive function (estrus signs) for therapy of females with gonadopathies (“Carafest”, “Caplaestrol” and “Caplagonìn”) and males (display of sexual reflexes and sperm quality) for reproductive activity dysfunction (“Carafand”), increase in the viability of the newborn (increasing the number of lambs and goatlings with satisfactory clinical condition with a high-growth potential, reduce in their morbidity and lethality), preventing the incidence of ìntra- and postnatal (labor hypofunction, diseases of post-labor period) pathology (“Carafest”, and “Caplaestrol”)

Epidemiology of traumatic injuries and associated infectious complications in the Republic of Kazakhstan

“…These patients need treatment correction in a hospital setting and often undergo surgical treatment. In the structure of traumatology and orthopedics microbial pathogens, the leading positions are occupied by Staphylococcus aureus and coagulase-negative staphylococci (CNS), which are represented mainly by Staphylococcus epidermidis [ 11 , 12 , 14 ], which is consistent with data from this study.…”

Assessment of the influence of N-acetylcysteine in vivo on sperm quality and hormone balance in boars

“…Подібні зміни показників якості сперми у кнурів встановлено за застосування вітамінно-гормональних препаратів (Skliarov et al, 2021), кормових добавок (Shostia et al, 2021) й корекції мінерального живлення кнурів (Karpovskyi et al, 2020). Отримані зміни гермінативної функції гонад, на нашу думку, відбувалися на тлі нормалізації балансу статевих гормонів.…”

Innovations in Modern Medicine and Biology

“…Thus, the developed vitamin-hormonal preparations on a plant and tissue basis have high efficiency in the treatment and prevention of reproductive pathologies of animals of various species, providing stimulation of reproductive function during the therapy of females with gonadopathy, increasing the viability of newborns, preventing the incidence of intra-and postnatal and andrological pathology [201].…”