The development of real-time two-dimensional doppler echocardiography and its clinical significance in acquired valvular diseases  With special reference to the evaluation of valvular regurgitation.

Omoto, Ryozo; Yokote, Yuji; Takamoto, Shinichi; Kyo, Shunei; Ueda, Keisuke; Asano, Haruhiko; Namekawa, Koroku; Kasai, Chihiro; Kondo, Yuji; Koyano, Akira

doi:10.1536/ihj.25.325

Cited by 276 publications

(47 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Doppler color flow imaging was used for the detection and semiquantification of tricuspid regurgitation (TR) (12), patent ductus arteriosus (PDA), and patent foramen ovale (PFO). The TR jet was observed from the apical four-chamber view or a subcostal window, PDA was imaged from the high left parasternal view, and PFO was imaged from the parasternal and subcostal window.…”

Section: Methodsmentioning

confidence: 99%

Usefulness of a New Doppler Index for Assessing Both Ventricular Functions and Pulmonary Circulation in Newborn Piglet With Hypoxic Pulmonary Hypertension

Sugiura¹,

Suzuki

Hussein³

et al. 2003

Pediatr Res

View full text Add to dashboard Cite

Persistent pulmonary hypertension of the newborn is a clinical syndrome associated with a variety of cardiopulmonary diseases. Serial evaluation of pulmonary circulation and cardiac function is important, but available imaging techniques have been limited. A new Doppler index combining systolic and diastolic time intervals (the Tei index, which is a simple and noninvasive measurement) has been reported to be useful for the assessment of global cardiac function in adults and children. The purpose of this study was to test the effectiveness of the Tei index in prospectively assessing ventricular function and pulmonary circulation in a newborn piglet model with hypoxic pulmonary hypertension. One-day-old piglets (1.1-1.6 kg) were intubated and prepared for the experiments under room air and hypoxia. A complete two-dimensional Doppler echocardiographic examination was performed. Common hemodynamic variables were measured continuously throughout the study. The right ventricle (RV) Tei index under hypoxia (fraction of inspired oxygen ϭ 0.10) was significantly higher than the value under air ventilation (medians, 0.38 versus 0.56; p Ͻ 0.05). Moreover, there was a significant correlation between RV Tei index and mean pulmonary artery pressure and positive linear correlation between individual changes in RV Tei index and changes in mPAP (r 2 ϭ 0.799, p Ͻ 0.05). We conclude that the Tei index is useful for assessing the function of the RV and the left ventricle and pulmonary circulation in a newborn piglet model with hypoxic pulmonary hypertension. These results suggest that the Tei index will become an objective method of assessing patients with persistent pulmonary hypertension of the newborn. Abbreviations PPHN, persistent pulmonary hypertension of the newborn RV, right ventricle LV, left ventricle PAP, pulmonary artery pressure HR, heart rate mPAP, mean pulmonary artery pressure SBP, systemic blood pressure mSBP, mean systemic blood pressure CVP, central venous pressure TR, tricuspid regurgitation PDA, patent ductus arteriosus PFO, patent foramen ovale ROC, receiver-operating characteristic RVPEP/RVEP, right ventricular preejection period/right ventricular ejection period Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome associated with a variety of cardiopulmonary diseases. Infants with PPHN are severely hypoxemic owing to a sustained elevation in pulmonary vascular resistance [and the resulting elevated pulmonary artery pressure (PAP)], with associated extrapulmonary shunting (1, 2). PPHN can be associated with a myriad of clinical conditions, such as meconium aspiration, asphyxia, and heart failure. Thus, serial evaluation of pulmonary circulation and cardiac function is important to assess accurately the clinical course, the efficacy of treatment, and the prognosis. The available imaging techniques have been limited, but a new Doppler echocardiographic index combining systolic and diastolic time intervals (the Tei index) has been reported to be useful for the assessment of global funct...

show abstract

Section: Methodsmentioning

confidence: 99%

Usefulness of a New Doppler Index for Assessing Both Ventricular Functions and Pulmonary Circulation in Newborn Piglet With Hypoxic Pulmonary Hypertension

Sugiura¹,

Suzuki

Hussein³

et al. 2003

Pediatr Res

View full text Add to dashboard Cite

show abstract

“…Exclusion criteria were heart failure, valvular heart disease including aortic regurgitation (ultrasound grade >I° [trivial]), 25 aortitis syndrome, aortic aneurysm, atrial fibrillation, carotid artery stenosis, prior symptomatic stroke events, and inadequate ultrasound signal quality. The final analysis included 296 patients (177 women and 119 men).…”

Section: Subjectsmentioning

confidence: 99%

Aortic Stiffness Determines Diastolic Blood Flow Reversal in the Descending Thoracic Aorta

2013

View full text Add to dashboard Cite

Abstract-Aortic stiffening often precedes cardiovascular diseases, including stroke, but the underlying pathophysiological mechanisms remain obscure. We hypothesized that such abnormalities could be attributable to altered central blood flow dynamics. In 296 patients with uncomplicated hypertension, Doppler velocity pulse waveforms were recorded at the proximal descending aorta and carotid artery to calculate the reverse/forward flow ratio and diastolic/systolic flow index, respectively. Tonometric waveforms were recorded on the radial artery to estimate aortic pressure and characteristic impedance (Z 0 ) and to determine carotid-femoral (aortic) and carotid-radial (peripheral) pulse wave velocities. In all subjects, the aortic flow waveform was bidirectional, comprising systolic forward and diastolic reverse flows. The aortic reverse/forward flow ratio (35±10%) was positively associated with parameters of aortic stiffness (including pulse wave velocity, Z 0 , and aortic/peripheral pulse wave velocity ratio), independent of age, body mass index, aortic diameter, and aortic pressure. The carotid flow waveform was unidirectional and bimodal with systolic and diastolic maximal peaks. There was a positive relationship between the carotid diastolic/systolic flow index (28±9%) and aortic reverse/ forward flow ratio, which remained significant after adjustment for aortic stiffness and other related parameters. The Bland-Altman plots showed a close time correspondence between aortic reverse and carotid diastolic flow peaks. In conclusion, aortic stiffness determines the extent of flow reversal from the descending aorta to the aortic arch, which contributes to the diastolic antegrade flow into the carotid artery. This hemodynamic relationship constitutes a potential mechanism linking increased aortic stiffness, altered flow dynamics, and increased stroke risk in hypertension.

show abstract

“…The subjects were divided into five age groups (group 1, 6-9 years old; group 2, [10][11][12][13][14][15][16][17][18][19] …”

mentioning

confidence: 99%

Color Doppler evaluation of valvular regurgitation in normal subjects.

et al. 1988

View full text Add to dashboard Cite

show abstract

The development of real-time two-dimensional doppler echocardiography and its clinical significance in acquired valvular diseases With special reference to the evaluation of valvular regurgitation.

Cited by 276 publications

References 2 publications

Usefulness of a New Doppler Index for Assessing Both Ventricular Functions and Pulmonary Circulation in Newborn Piglet With Hypoxic Pulmonary Hypertension

Usefulness of a New Doppler Index for Assessing Both Ventricular Functions and Pulmonary Circulation in Newborn Piglet With Hypoxic Pulmonary Hypertension

Aortic Stiffness Determines Diastolic Blood Flow Reversal in the Descending Thoracic Aorta

Color Doppler evaluation of valvular regurgitation in normal subjects.

Contact Info

Product

Resources

About