The Development of Respiratory Syncytial Virus-Specific IgE and the Release of Histamine in Nasopharyngeal Secretions after Infection

Welliver, Robert C.; Wong, David; Sun, Martha; Middleton, Elliott; Vaughan, Russell S.; Ogra, Pearay L.

doi:10.1056/nejm198110083051501

Cited by 509 publications

(251 citation statements)

References 19 publications

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“…The evidence for this can be obtained from cultures, antigen detection, or serologic responses compared with random controls (11)(12)(13). Similar results have been obtained in population-based studies (14).…”

Section: Bronchiolitis and Respiratory Syncitial Virus In The First Tsupporting

confidence: 53%

“…The relevance of the immune response to RSV has been debated for many years. Welliver and his colleagues reported the presence of nasal IgE antibodies specific for RSV (11 (5,12,13,27). By the time children have reached middle school (10-13 years of age), asthma is very strongly associated with positive skin tests to common inhalant allergens.…”

Section: Bronchiolitis and Respiratory Syncitial Virus In The First Tmentioning

confidence: 99%

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Specific and Nonspecific Obstructive Lung Disease in Childhood: Causes of Changes in the Prevalence of Asthma

Platts‐Mills¹,

Carter²,

Heymann³

2000

Environmental Health Perspectives

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Reversible airway obstruction in childhood includes two major groups of patients: those with recurrent wheezing following bronchiolitis in early childhood, and those with allergic asthma, which represents an increasingly large proportion of cases through the school years. Over the last 40 years of the 20th century, allergic asthma has increased in many countries and in relation to several different allergens. Although this increase has differed in magnitude in different countries and also in the social groups most affected, it has had several features in common. The increase generally started between 1960 and 1970, has been progressive since then, and has continued into the 1990s without a defined peak. Among children 5-18 years of age, the increase has predominantly been among allergic individuals. Theories about the causes of the increase in asthma have focused on two scenarios: a) that changes in houses combined with increased time spent indoors have increased exposure to relevant allergens, or b) that changes in diet, antibiotic use, immunizations, and the pattern of infections in childhood have led to a change in immune responsiveness such that a larger section of the population makes TH2, rather than TH1 responses including IgE antibodies to inhalant allergens. There are, however, problems with each of these theories and, in particular, none of the proposed changes can explain the progressive nature of the increase over 40 years. The fact that the change in asthma has much in common with epidemic increase in diseases such as Type II diabetes or obesity suggests that similar factors could be involved. Several lines of evidence are reviewed that suggest that the decline in physical activity of children, particularly those living in poverty in the United States, could have contributed to the rise in asthma. The hypothesis would be that the progressive loss of a lung-specific protective effect against wheezing has allowed allergic children to develop symptomatic asthma. What is clear is that current theories do not provide either an adequate explanation of the increase or a practical approach to reversing the current trend.

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Section: Bronchiolitis and Respiratory Syncitial Virus In The First Tsupporting

confidence: 53%

Section: Bronchiolitis and Respiratory Syncitial Virus In The First Tmentioning

confidence: 99%

Specific and Nonspecific Obstructive Lung Disease in Childhood: Causes of Changes in the Prevalence of Asthma

Platts‐Mills¹,

Carter²,

Heymann³

2000

Environmental Health Perspectives

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“…While herpesvirus infections early in life may help prevent AD, infections with herpes simplex and Coxsackie virus in patients with established AD can lead to eczema herpeticum and Coxsakium, respectively [136,137]. Moreover, some studies found that infections with respiratory syncytial virus may actually increase the risk of disease [73,[75][76][77][78]. Finally, it is well established that patients with AD have increased colonization of both lesional and nonlesional skin with Staphylococcal aureus and decreased microbial diversity [79][80][81][82].…”

Section: Hygiene Hypothesismentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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“…Also, the level of HRSV-specific IgE response after primary infection is useful in predicting future episodes of wheezing (91). Recently, a defect in suppressor cell numbers and function was reported in infants with HRSV-bronchiolitis, which may explain the overproduction of IgE and exaggerated lymphocyte proliferation response (discussed later) in these patients (107). Possibly, the severe form of HRSV infection occurs only in those individuals with a hereditary tendency to overproduce IgE.…”

Section: Prior Sensitising Infection (Type I Hypersensitivity)mentioning

confidence: 99%

Human and bovine respiratory syncytial virus: Immunopathologic mechanisms

Baker

1991

Veterinary Quarterly

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The Development of Respiratory Syncytial Virus-Specific IgE and the Release of Histamine in Nasopharyngeal Secretions after Infection

Cited by 509 publications

References 19 publications

Specific and Nonspecific Obstructive Lung Disease in Childhood: Causes of Changes in the Prevalence of Asthma

Specific and Nonspecific Obstructive Lung Disease in Childhood: Causes of Changes in the Prevalence of Asthma

Environmental risk factors and their role in the management of atopic dermatitis

Human and bovine respiratory syncytial virus: Immunopathologic mechanisms

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