The Development of the Mesenteric Model of Abdominal Anatomy

Byrnes, Kevin Gerard; Cullivan, Orla; Walsh, Dara; Coffey, J. Calvin

doi:10.1055/s-0042-1743585

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…To understand bodily function, it is necessary to study embryology, from which the function developed [ 17 ]. Furthermore, the anatomy in books does not always reflect the anatomy of living things, and anatomy itself should be reevaluated starting from ontogenesis [ 62 ].…”

Section: Reviewmentioning

confidence: 99%

Fascial Nomenclature: Update 2024

Bordoni,

Escher,

Castellini

et al. 2024

Cureus

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The fascial system is the focus of multiple scientific disciplines, and its nomenclature is debated. What tissue should fall under the definition of fascia? Considering university anatomy books where what is considered connective tissue is described as a fact, and through the science of embryology, which allows us to identify the origin of different body tissues, the article reviews and updates the fascial nomenclature. The text is not a point of arrival but rather a basis from which to start again, with the aim of understanding the function of the fascial continuum in the living. The history of fascial nomenclature in historical and modern contexts is reviewed, including the scientific perspective of the Foundation of Osteopathic Research and Clinical Endorsement (FORCE) organization. The latter has no profit-making purposes and does not hold any copyright.

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Section: Reviewmentioning

confidence: 99%

Fascial Nomenclature: Update 2024

Bordoni,

Escher,

Castellini

et al. 2024

Cureus

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show abstract

“…The innervation of the sensory visceral peritoneum is by the spinal nerves and the vagus nerve; the stresses that stimulate the afferents from the visceral peritoneum are of the mechanical type, such as stretching and deformation [ 25 ]. The mesentery (fan-shaped fold of peritoneum) is affected by spinal nerves from T5 to T12; the anatomical area involves the duodenojejunal flexure, the oesophagogastric junction up to the mesorectum [ 25 , 26 ].…”

Section: Reviewmentioning

confidence: 99%

Peritoneal Adhesions in Osteopathic Medicine: Theory, Part 1

Bordoni,

Escher,

Girgenti

2023

Cureus

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Peritoneal adhesions form as a result of trauma to the abdomen, injuries resulting from surgery, and infections. These tissutal neoformations are innervated and vascularized, and with lymphatic vessels, adherence becomes a new and independent structure, capable of negatively influencing visceral functions. Adherent neogenesis can be asymptomatic or can be a source of pain, limiting the patient's quality of life. Although adhesiolysis remains the elective approach to eliminate adhesions, this therapeutic route prepares the peritoneal anatomical area to recur. The article reviews information on adhesion formation and peritoneal anatomy, probable subjective predispositions, and pathways that carry nociception. The text aims to be a theoretical basis for making new treatment suggestions for non-invasive osteopathic medicine, through a second part will be discussed in another article.

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“…The pancreas begins in the caudal ventral and dorsal pancreatic buds of the protointestine, located in almost the same area as the beginning of liver development, and early on the protointestine is wrapped in an intact membranous tethered structure, which develops into the mesentery as the embryo gradually matures. In recent years it has been hypothesised that this membranous tethered structure is used in the development of the liver and In recent years, it has been hypothesised that this structure is preserved during the development of the liver and pancreas, and that the mature liver, bile and pancreas form physiological adhesions through these.This has led to the hypothesis that a local microcirculatory system between the pancreas and liver may be formed through the vasculature and lymphatic vessels of the mesentery, which act as a bridge for the various cytokines that cause direct damage to the liver during the course of pancreatitis 4,5,6,7 .…”

Section: Introductionmentioning

confidence: 99%

Evaluating Bovine Umbilical Cord Stem Cells and Glutamine for Hepatic Injury in Acute Pancreatitis

Guan

2023

Preprint

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Acute pancreatitis (AP) is a localized-to-systemic inflammatory disorder that triggers the release of various proinflammatory mediators. Unfortunately, effective treatments for this condition are currently lacking, and a substantial portion of AP patients succumb to liver failure due to the intricate physiological and pathological interplay between the liver and pancreas.Umbilical cord mesenchymal stem cells (UCMSCs) exhibit notable attributes, including multipotent differentiation capacity, colony-forming potential, and robust migratory responses to injury. Glutamine, an essential amino acid in cell culture and a source of immune cells, is used in early nutritional interventions to help with pancreatitis.In this study, our objective was to evaluate the therapeutic efficacy of a combinatorial approach involving UCMSCs and glutamine in the management of hepatic injury associated with pancreatitis. To accomplish this objective, we established an acute pancreatitis murine model and administered UCMSCs via tail vein njections while concurrently providing oral glutamine supplementation. The homing of these cells was observed in rats through fluorescence microscopy. A comprehensive array of techniques was employed to assess treatment outcomes.Histopathological examination, as revealed by HE staining, demonstrated a significantly reduced extent of pancreatic tissue damage in both the UCMSC-treated and combined therapy groups compared to the AP control group. Serum amylase and lipase activities were markedly diminished in the UCMSC and combined therapy groups in comparison to the untreated AP group (P<0.05). Furthermore, the expression levels of proinflammatory cytokines such as IL-6, IL-1β, and TNF-α were significantly attenuated, while those of the anti-inflammatory IL-10 and SOD were notably elevated in the UCMSC-treated and combined therapy groups (P<0.05).The assessment of apoptosis, a pivotal aspect of tissue damage in pancreatitis, demonstrated a significantly higher apoptotic index in the untreated AP group (P<0.05), whereas it was significantly lower in the UCMSC-treated and combined therapy groups (P<0.05). Our findings indicate that the combined therapeutic approach involving UCMSCs and glutamine substantially mitigates hepatocyte apoptosis induced by acute pancreatitis (AP). However, there was no statistically significant difference in efficacy between combination therapy and direct mesenchymal stem cell (MSC) therapy in ameliorating liver injury in the context of pancreatitis(P>0.05). While combination glutamine therapy presents a promising and novel therapeutic avenue, its efficacy not diverges from that of direct cell-based regimens.

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The Development of the Mesenteric Model of Abdominal Anatomy

Cited by 5 publications

References 54 publications

Fascial Nomenclature: Update 2024

Fascial Nomenclature: Update 2024

Peritoneal Adhesions in Osteopathic Medicine: Theory, Part 1

Evaluating Bovine Umbilical Cord Stem Cells and Glutamine for Hepatic Injury in Acute Pancreatitis

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