The development of the modern oxygenator

Haworth, William S.

doi:10.1016/j.athoracsur.2003.09.012

Cited by 39 publications

(18 citation statements)

References 5 publications

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“…As the oxygen-poor blood flows across the hollow fiber bundle, it generates transverse mixing that is essential for enhanced gas exchange between oxygen inside the fiber and the carbon dioxide from the blood flowing over the bundle. Hollow fiber modules are widely used in bioprocesses (Heath and Belfort, 1990; Ghosh et al, 2000) and in biomedical fields (Fukuda et al, 1998; Kolobow et al, 1986; Haworth, 2003) because of their high mass transfer performance. One of the most essential hollow fiber modules is a membrane oxygenator.…”

Section: Introductionmentioning

confidence: 99%

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

2012

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A numerical study was conducted to analyze fluid flow within hollow fiber membranes of the artificial lungs. The hollow fiber bundle was approximated using a porous media model. In addition, the transport equations were solved using the finite-element formulation based on the Galerkin method of weighted residuals. Comparisons with previously published work on the basis of special cases were performed and found to be in excellent agreement. A Newtonian viscous fluid model for the blood was used. Different flow models for porous media, such as the Brinkman-extended Darcy model, Darcy’s law model, and the generalized flow model, were considered. Results were obtained in terms of streamlines, velocity vectors, and pressure distribution for various Reynolds numbers and Darcy numbers. The results from this investigation showed that the pressure drop across the artificial lung device increased with an increase in the Reynolds number. In addition, the pressure drop was found to increase significantly for small Darcy numbers.

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Section: Introductionmentioning

confidence: 99%

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

2012

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“…By 1955, Kirklin et al reported a successful series of repairs utilizing extracorporeal more expensive than the bubble oxygenators. Membrane oxygenators were saved for longer operations and extracorporeal membrane oxygenation (ECMO) [23]. In the 1980s, development of hollow polycarbonate siloxane fi bers and improvements in manufacturing techniques neutralized the disadvantages of membrane oxygenators.…”

Section: Historical Perspectivementioning

confidence: 99%

Cardiopulmonary Bypass

McLean¹,

Lombardi²,

Pearl³

2008

Cardiovascular Pediatric Critical Illness and Injury

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“…In industry, the current design specifications for blood recirculating devices (BRDs) used in extracorporeal circulation (ECC) are mainly focused on macroscale parameters, such as the minimization of pressure losses and priming volumes, and on the optimization of gas and heat transfer efficiency (Haworth 2003). The typical industrial design approach is largely based on time-consuming and often inefficient empirical approaches, and the device fluid dynamics is mainly investigated using experimental techniques (Fiore et al 1998; Mueller et al 1998; Kawahito et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation

Pelosi

Sheriff

Stevanella

et al. 2012

Biomech Model Mechanobiol

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The onset of thromboembolic phenomena in blood oxygenators, even in the presence of adequate anticoagulant strategies, is a relevant concern during extracorporeal circulation (ECC). For this reason, the evaluation of the thrombogenic potential associated with extracorporeal membrane oxygenators should play a critical role into the preclinical design process of these devices. This study extends the use of computational fluid dynamics simulations to guide the hemodynamic design optimization of oxygenators and evaluate their thrombogenic potential during ECC. The computational analysis accounted for both macro- (i.e., vortex formation) and micro-scale (i.e., flow-induced platelet activation) phenomena affecting the performances of a hollow-fiber membrane oxygenator with integrated heat exchanger. A multiscale Lagrangian approach was adopted to infer the trajectory and loading history experienced by platelet-like particles in the entire device and in a repetitive subunit of the fiber bundles. The loading history was incorporated into a damage accumulation model in order to estimate the platelet activation state (PAS) associated with repeated passes of the blood within the device. Our results highlighted the presence of blood stagnation areas in the inlet section that significantly increased the platelet activation levels in particles remaining trapped in this region. The order of magnitude of PAS in the device was the same as the one calculated for the components of the ECC tubing system, chosen as a term of comparison for their extensive diffusion. Interpolating the mean PAS values with respect to the number of passes, we obtained a straightforward prediction of the thrombogenic potential as a function of the duration of ECC.

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The development of the modern oxygenator

Cited by 39 publications

References 5 publications

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

Cardiopulmonary Bypass

Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation

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