The development of the Tuebingen Cushing’s disease quality of life inventory (Tuebingen CD‐25). Part I: construction and psychometric properties

Milian, Monika; Teufel, Philipp; Honegger, Juergen; Gallwitz, Baptist; Schnauder, Günter; Psaras, Tsambika

doi:10.1111/j.1365-2265.2011.04191.x

Cited by 36 publications

(42 citation statements)

References 24 publications

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“…For the development of the Tuebingen CD-25 [17,18] technical literature, a board of experienced endocrinologists, pituitary surgeons and a neuropsychologist as well as previously treated patients with CD were consulted. The Tuebingen CD-25 inventory covers the six most essential HRQoL dimensions in CD: (1) depression, (2) sexual activity, (3) environment, (4) eating behaviour, (5) bodily restrictions and (6) cognition.…”

Section: Methodsmentioning

confidence: 99%

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Tuebingen CD-25 Is a Sensitive Tool to Investigate Health-Related Quality of Life in Cushing's Disease Patients in the Course of the Disease

Milian¹,

Honegger²,

Teufel³

et al. 2013

Neuroendocrinology

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Background: The primary object was to investigate whether the Tuebingen CD-25 captures changes in health-related quality of life (HRQoL) sensitively in Cushing's disease (CD) and to identify factors that favour postoperative HRQoL. Methods: 17 CD patients were scheduled for transsphenoidal tumour removal and filled out the inventory before and after surgery. The mean time elapsed after surgery was 14.4 ± 11.3 months. All patients were in remission at the second timepoint of investigation. Results: HRQoL as assessed with the Tuebingen CD-25 improved significantly after successful surgical tumour removal. A large effect size (Cohen's d = 0.84) in the total score indicates good sensitivity to change. 13 patients (76.5%) showed impaired HRQoL preoperatively compared with a general population sample. Postoperatively, 35.3% of the patients still suffered from an impaired HRQoL. Stepwise linear regression analysis revealed that less comorbidities (≤2) and greater morning cortisol decrease were promotive factors for better postoperative HRQoL (p < 0.05). The postoperative improvement in HRQoL could be best predicted by the presence of preoperative HRQoL impairment and age of the patients, i.e. patients who were younger were more likely to improve. Moreover, patients without postoperative pituitary deficiencies improved significantly more in the cognition scale. A tendency towards more improvement in overall HRQoL was observed in non-hypocortisolaemic patients. Conclusions: The Tuebingen CD-25 has proved to be a capable and sensitive instrument to investigate HRQoL in the course of disease. The number of postoperative comorbidities had the greatest impact on postoperative well-being.

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Section: Methodsmentioning

confidence: 99%

“…With the aim to evaluate HRQoL in CD patients in its multidimensionality, the authors previously introduced a reliable and suitable instrument, the Tuebingen CD quality of life inventory (Tuebingen CD-25) [17,18]. The questionnaire consists of 25 items and covers six essential domains of HRQoL.…”

Section: Introductionmentioning

confidence: 99%

Tuebingen CD-25 Is a Sensitive Tool to Investigate Health-Related Quality of Life in Cushing's Disease Patients in the Course of the Disease

Milian¹,

Honegger²,

Teufel³

et al. 2013

Neuroendocrinology

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“…Further verification of construct validity (contrast groups) was obtained by means of HRQoL comparisons in relation to the current disease status (patients without vs. with hypercortisolism). Since the group of hypercortisolemic patients (n = 10) in the present sample was too small for statistical comparisons, we included the data of 43 nonredundant patients from the Tuebingen CD-25 development study [4,10] and the data of 12 recently diagnosed hypercortisolemic (i.e. after admission for neurosurgical treatment) CD patients from the Department of Neurosurgery in Tuebingen, amounting to a total sample size of 55 hypercortisolemic CD patients.…”

Section: Methodsmentioning

confidence: 99%

“…For the development of the Tuebingen CD-25 [10] technical literature, a board of experienced endocrinologists, pituitary surgeons, and a neuropsychologist, as well as previously treated patients with CD, were consulted. For the development of the present inventory, a preliminary inventory comprising 64 HRQoL items was handed out to 63 CD patients.…”

Section: Methodsmentioning

confidence: 99%

“…The instrument covers 6 domains of HRQoL in CD (i.e. mood, sexual activity, social environment, eating behavior, physical aspects, and cognitive functioning) and provides a total score [10]. The inventory has shown excellent internal consistency (Cronbach's α = 0.94) and a high validity (correlation coefficients between -0.65 and -0.74) [5,10], determined by the correlations between the total score of the Tuebingen CD-25 and the overall score of the established WHO Quality of Life-BREF (WHOQoL-BREF [11]).…”

Section: Introductionmentioning

confidence: 99%

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Validation of the Tuebingen CD-25 Inventory as a Measure of Postoperative Health-Related Quality of Life in Patients Treated for Cushing's Disease

Milian¹,

Kreitschmann-Andermahr²,

Siegel

et al. 2015

Neuroendocrinology

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Background: To evaluate the construct and criterion validity of the Tuebingen Cushing's disease quality of life inventory (Tuebingen CD-25) for application in patients treated for Cushing's disease (CD). Methods: A total of 176 patients with adrenocorticotropin hormone-dependent CD (144 of them female, overall mean age 46.1 ± 13.7 years) treated at 3 large tertiary referral centers in Germany were studied. Construct validity was assessed by hypothesis testing (self-perceived symptom reduction assessment) and contrasted groups (patients with vs. without hypercorticolism). For this purpose, already existing data from 55 CD patients was used, representing the hypercortisolemic group. Criterion validity (concurrent validity) was assessed in relation to the Cushing's quality of life questionnaire (CushingQoL), the Short Form 36 health survey (SF-36), and the body mass index (BMI). Results: Patients with self-perceived remarkable symptom reduction had significant lower Tuebingen CD-25 scores (i.e. better health-related quality of life) than patients with self-perceived insufficient symptom reduction (p < 0.05). Similarly, the mean scores of the Tuebingen CD-25 scales were lower in patients without hypercortisolism (total score 27.0 ± 17.2) compared to those with hypercortisolism (total score 45.3 ± 22.1; each p < 0.05), providing evidence for construct validity. Criterion validity was confirmed by the correlations between the Tuebingen CD-25 total score and the CushingQoL (Spearman's coefficient -0.733), as well as all scales of the SF-36 (Spearman's coefficient between -0.447 and -0.700). Conclusion: The analyses presented in this large-sample study provide robust evidence for the construct and criterion validity of the Tuebingen CD-25.

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Long-Term Effects of Prior Cushing’s Syndrome

Aulinas

Valassi

Resmini

et al. 2016

The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

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The development of the Tuebingen Cushing’s disease quality of life inventory (Tuebingen CD‐25). Part I: construction and psychometric properties

Abstract: The Tuebingen CD-25 is a valid and reliable instrument to evaluate HRQoL in CD. Based on impairment of HRQoL for the different subdimensions, specific support can be offered to the patients.

Cited by 36 publications

References 24 publications

Tuebingen CD-25 Is a Sensitive Tool to Investigate Health-Related Quality of Life in Cushing's Disease Patients in the Course of the Disease

Tuebingen CD-25 Is a Sensitive Tool to Investigate Health-Related Quality of Life in Cushing's Disease Patients in the Course of the Disease

Validation of the Tuebingen CD-25 Inventory as a Measure of Postoperative Health-Related Quality of Life in Patients Treated for Cushing's Disease

Long-Term Effects of Prior Cushing’s Syndrome

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