The development of thymol–isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity

Singh, Atamjit; Kaur, Kirandeep; Mohana, Pallvi; Singh, Karanvir; Sharma, Aman; Prajapati, Jignesh; Goswami, Dweipayan; Khosla, Neha; Kaur, Uttam; Kaur, Rajanbir; Kaur, Rajinder; Rana, Abhineet; Kour, Sandeep; Ohri, Puja; Arora, Saroj; Chadha, Renu; Singh Bedi, Preet Mohinder

doi:10.1039/d3md00580a

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Singh and collaborators investigated thymol-isatin hybrid activity against resistant bacteria, methicillin-resistant Staphylococcus aureus (MRSA). The results showed low concentrations of MIC = 1.9 µM and MBC = 3.9 µM, that they were also capable of inhibiting biofilm formation, and that they decreased virulence factor staphyloxanthin production [33].…”

Section: Resultsmentioning

confidence: 99%

“…MDR and XDR M. tuberculosis strains have also been studied for isatin derivates [32]. Regarding the evaluation of the cytotoxicity of isatin and its derivatives, these have been shown to have lower toxicity and be safer in several investigations [24,33]. However, although several bacterial strains have been evaluated, the genus Campylobacter and effects at the cellular level have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Antibacterial Activity of Isatin against Campylobacter jejuni and Campylobacter coli Strains

Barroso,

Seki,

Esteves

et al. 2024

Applied Microbiology

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Antibiotic resistance, particularly against fluoroquinolones and macrolides, has emerged globally among thermophilic Campylobacters (Campylobacter jejuni and Campylobacter coli), giving rise to concerns about the efficacy of antibiotic treatment of these bacteria. Thus, developing new antibacterials with excellent activity is important. Isatin (IST) and its derivatives have exhibited promising antibacterial activities in several pathogenic bacteria. However, its activity against Campylobacter is unknown. Therefore, this study was conducted to evaluate the antibacterial activity of isatin against 29-Campylobacter strains (C. jejuni-17 and C. coli-12) and investigate the effects at the cellular level. The minimal inhibitory concentrations (MICs) of isatin were between <1.0 and 16.0 µg/mL in Campylobacter strains. Most strains presented with MIC = 8.0 µg/mL (76%). The minimal bactericidal concentration (MBC) was determined to be 16.0 µg/mL for 72% of the Campylobacter strains tested. The 50% inhibitory concentration (IC50) value for isatin was 125.63 µg/mL on the MRC-5 normal cell line, suggesting that isatin can be considered a safe substance in terms of cytotoxicity. In this study, we demonstrated the potential of isatin based on its low toxicity and effectiveness in vitro against antibiotic-resistant Campylobacter strains, which indicates that this compound could be an attractive candidate for future use in multidrug-resistant Campylobacter treatment.

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Section: Resultsmentioning

confidence: 99%