The Development of Vaccines against Gastrointestinal Nematode Parasites, Particularly Haemonchus contortus

Newton, Susan E; Munn, E. A.

doi:10.1016/s0169-4758(99)01399-x

Cited by 190 publications

(109 citation statements)

References 61 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Natural immunity to gastro-intestinal nematodes will develop in older animals and, with continued exposure to infective larvae, the immunity is maintained. This protective response can largely be attributed to immune response to excretory/secretory antigens (Newton & Munn 1999). Over the years, many attempts have been made to induce immunity to gastro-intestinal nematodes, particularly those of sheep, with excretory/ secretory preparations, including vaccination against Haemonchus contortus, Taenia circumcincta and Trichostrongylus colubriformis, resulting in reductions in faecal egg counts and/or worm burdens of up to 70% (Emery & Wagland 1991, Emery 1996, Newton & Munn 1999.…”

Section: Discussionmentioning

confidence: 99%

Preliminary analysis of Sm14 in distinct fractions of Schistosoma mansoni adult worm extract

Thaumaturgo

Vilar

Diogo

et al. 2001

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Preliminary analysis of Sm14 in distinct fractions of Schistosoma mansoni adult worm extract

Thaumaturgo

Vilar

Diogo

et al. 2001

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

“…While progress on vaccines against nematodes continues to move forward, it does so with mixed success. The remarkable protection that can be induced with natural antigens derived from the intestine of Haemonchus contortus (Newton and Munn, 1999) is an example of one form of success. Nevertheless, other parasites present greater challenges for identification of good vaccine candidates (e.g.…”

Section: Vaccinationmentioning

confidence: 99%

“…Optimal progress requires integration of both EST and whole genome data. One example is the nematode intestine, which in H. contortus has demonstrated application to chemotherapy, parenteral immunization and potentially mucosal immunization (Jasmer et al, 2007;Newton and Munn, 1999). In each case, apical intestinal membrane proteins were the subjects of investigation.…”

Section: Pan-phylum Analysismentioning

confidence: 99%

Parasitic nematodes—From genomes to control

Mitreva

Zarlenga

McCarter

et al. 2007

Veterinary Parasitology

View full text Add to dashboard Cite

The diseases caused by parasitic nematodes in domestic and companion animals are major factors that decrease production and quality of the agricultural products. Methods available for the control of the parasitic nematode infections are mainly based on chemical treatment, non-chemical management practices, immune modulation and biological control. However, even with integrated pest management that frequently combines these approaches, the effective and long-lasting control strategies are hampered by the persistent exposure of host animals to environmental stages of parasites, the incomplete protective response of the host and acquisition of anthelmintic resistance by an increasing number of parasitic nematodes. Therefore, the challenges to improve control of parasitic nematode infections are multi-fold and no single category of information will meet them all. However, new information, such as nematode genomics, functional genomics and proteomics, can strengthen basic and applied biological research aimed to develop improvements.In this review we will, summarize existing control strategies of nematode infections and discuss ongoing developments in nematode genomics. Genomics approaches offer a growing and fundamental base of information, which when coupled with downstream functional genomics and proteomics can accelerate progress towards developing more efficient and sustainable control programs. #

show abstract

“…Several control measures are available (Waller, 1999) like vaccination (Bain, 1999;Newton and Munn, 1999;Smith, 1999), breeding of resistant sheep races (Gray, 1997), improvement of food quality Datta et al, 1999;Coop and Kyriazakis, 1999;Knox, 2002) and better methods of breeding and dairy farming Barger, 1999;Niezen et al, 1999). In addition, biological measures are being developed (de Gives et al, 1999;Larsen, 1999;Pena et al, 2002) and the use of anthelminthics already present on the market has to be optimised (Hennessy, 1997;Smith et al, 1999;Van Wyk and Bath, 2002).…”

Section: Introductionmentioning

confidence: 99%

Prospect for anthelminthic plants in the Ivory Coast using ethnobotanical criteria

Diehl

Atindehou

Téré

et al. 2004

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Sixty plant species were collected in the Ivory Coast on the basis of an ethnobotanical literature using the following three criteria: activity against worms, diarrhoea and/or abdominal pain. Eighty six plant extracts were prepared using 90% ethanol and tested for potential anthelminthic activities with a larvicidal test of Haemonchus contortus. 25.6% of the extracts showed a high activity, 12.8% were active or marginally active and the remaining 61.6% were inactive. The fact that a relatively high percentage of the plants species (50%) had an activity can be explained by the initial preselection of the plants on the basis of ethnobotanical indications.

show abstract

The Development of Vaccines against Gastrointestinal Nematode Parasites, Particularly Haemonchus contortus

Cited by 190 publications

References 61 publications

Preliminary analysis of Sm14 in distinct fractions of Schistosoma mansoni adult worm extract

Preliminary analysis of Sm14 in distinct fractions of Schistosoma mansoni adult worm extract

Parasitic nematodes—From genomes to control

Prospect for anthelminthic plants in the Ivory Coast using ethnobotanical criteria

Contact Info

Product

Resources

About