The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activity

Laat, Melody A. de; Kyaw-Tanner, Myat T.; Nourian, Alireza; McGowan, Catherine; Sillence, Martin N.; Pollitt, Christopher C.

doi:10.1016/j.vetimm.2011.01.013

Cited by 46 publications

(30 citation statements)

References 27 publications

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“…Neste estudo, houve aumento da forma de MMP-9 conjugada ao NGAL (C_MMP-9/NGAL), um composto associado a neutróϐilos, o que suporta a participação da MMP-9 na resposta inϐlamató-ria. De Laat et al (2011) demonstraram por PCR e zimograϐia que dentre várias metaloproteinases e seus inibidores, a única substância que apresentou aumento signiϐicativo em cavalos após 48 horas de indução de laminite foi a MMP-9.…”

Section: Resultsunclassified

Lipocalina associada à gelatinase de neutrófilos (NGAL) e calprotectina no tecido laminar de equinos após obstrução jejunal, tratados ou não com hidrocortisona

Laskoski

Valadão

Vasconcelos³

et al. 2012

Pesq. Vet. Bras.

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Section: Resultsunclassified

Lipocalina associada à gelatinase de neutrófilos (NGAL) e calprotectina no tecido laminar de equinos após obstrução jejunal, tratados ou não com hidrocortisona

Laskoski

Valadão

Vasconcelos³

et al. 2012

Pesq. Vet. Bras.

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“…The dynamic balance between the degradation and synthesis of collagen in the extracellular matrix in physiological conditions is sustained by the cooperation of matrix metalloproteinases (MMP) and their tissue inhibitors (tissue inhibitors of metalloproteinases). The unregulated activity of MMP, particularly MMP-2 and MMP-9, which are responsible for type IV collagen degradation, may lead to hoof tissue damage -the destruction of basement membrane -and consequently, to distal phalangeal attachment apparatus damage (Orsini et al 2009;Huntington et al 2010;De Laat et al 2011;Katz & Bailey 2012). The production and later activation of MMPs are observed during local or systemic inflammatory states, ischaemia, or as a result of bacterial toxins' presence.…”

Section: Ir As a Cause Of Laminitismentioning

confidence: 99%

“…It was thought that chronic hyperinsulinemia-related glucotoxicity, hypoperfusion, elevated release of reactive oxygen species or haemodynamic changes lead finally to MMP activation and cause insulin-induced laminitis (De Laat et al 2011;Katz & Bailey 2012). The research on insulin-induced laminitis proved that during the developmental and acute stage of laminitis, the expression of the genes coding for MMP-2 was not triggered.…”

Section: Ir As a Cause Of Laminitismentioning

confidence: 99%

Insulin resistance in the horse: a review

Kaczmarek

Janicki

Głowska

2015

Journal of Applied Animal Research

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Insulin resistance (IR) is a state in which the tissues show a reduced sensitivity to insulin despite its normal or even increased concentration in blood. IR causes inability of peripheral tissues to respond to the hormone and to increase the glucose uptake from blood nor to raise the metabolism rate. The tissues resistance to insulin may refer to the prereceptor malfunctions, which reduce the concentration of insulin or decrease the number of insulin receptors; however, in most cases changes in signal transduction after insulin binding to the receptor are observed. The development of IR is determined by a number of genetic and environmental factors. One of the most relevant causes is obesity, which develops into a growing problem among the horse population all over the world. The accumulation of lipids in the tissues (lipotoxicity) and a mild inflammation caused by the release of proinflammatory adipokines and cytokines from the fat tissue are a common denominator that links obesity with IR. Both IR and obesity seem to cause metabolism malfunctions in horses and are the key components of equine metabolic syndrome; moreover, both may be the reason for endocrinological laminitis. The methods of prevention and treatment of IR include feeding the animals with low glycemic index food and increasing physical activity as well as pharmacological treatment, where levothyroxine sodium and metformin are of the highest importance. ARTICLE HISTORY

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“…Previous reports (7,14) have measured MMP-2 expression at one point-in-time, and could not determine the effects of MMP-2 during the whole acute developmental phase of equine laminitis. In this study circulating MMP-2 was measured continuously, in order to determine the role of MMP-2 in the whole acute developmental phase of oligofructose-induced equine laminitis.…”

Section: Introductionmentioning

confidence: 97%

“…Typical experimental models of laminitis include alimentary overload of carbohydrates (starch or oligofructose), black walnut heartwood extract, and intravenous infusion of insulin (2,7,27). These models have all been shown to replicate closely the natural causes of laminitis, especially the cause of unusual hind gut fermentation resulting from consumption of excessive grain or lush pasture grasses (11).…”

Section: Introductionmentioning

confidence: 99%

MMP-2 Plays an Important Role During the Early Acute Developmental Phase of Oligofructose-Induced Equine Laminitis

Jiang

Wang

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The study was conducted on 24 Mongolian horses, with oligofructose-induced equine laminitis (10 g/kg b.w.). The objective of the study was to investigate the relationships among matrix metalloproteinase 2 (MMP-2), P38 mitogen-activated protein kinases (P38 MAPK), tissue inhibitor of metalloproteinase 2 (TIMP-2), lipopolysaccharides (LPS), and tumour necrosis factor-α (TNF-α) during acute developmental phase of laminitis, and to determine whether there are any characteristic tendencies. Moreover, plasma concentrations of LPS and TNF-α were measured in order to determine the time of leukocytes' activation. Eleven of the 12 horses showed clinical signs of laminitis. The contents of MMP-2 and P38 MAPK increased significantly from 8 h to 64 h, and the content of TIMP-2 decreased significantly at the same time. Plasma LPS concentrations increased significantly between 8 h and 20 h and reached a peak of 0.024 ± 0.009 EU/mL (equivalent to 3.04 ± 1.19 pg/mL) at 12 h. TNF-α concentration increased between 20 h and 36 h. This data indicates that MMP-2 plays an important role during the early acute developmental phase of oligofructose-induced equine laminitis.

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The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activity

Cited by 46 publications

References 27 publications

Lipocalina associada à gelatinase de neutrófilos (NGAL) e calprotectina no tecido laminar de equinos após obstrução jejunal, tratados ou não com hidrocortisona

Lipocalina associada à gelatinase de neutrófilos (NGAL) e calprotectina no tecido laminar de equinos após obstrução jejunal, tratados ou não com hidrocortisona

Insulin resistance in the horse: a review

MMP-2 Plays an Important Role During the Early Acute Developmental Phase of Oligofructose-Induced Equine Laminitis

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