The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response

Aalberse, Rob C.; Platts-Mills, Thomas A.E.; Rispens, Theo

doi:10.1007/s11882-016-0621-x

Cited by 68 publications

(67 citation statements)

References 51 publications

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“…Meantime, the increasing levels of IL-17, IL-6 and GM-CSF further enhance the function of IL-4 and IL-13. 27 Moreover, the IgG1, associated with protecting against allergic reactions in mice, 28 was regulated by IL-4 and enhanced by the large temperature variation (Fig. 2B).…”

Section: Discussionmentioning

confidence: 95%

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Kang

Chen

et al. 2018

Respirology

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Background and objective Studies from epidemiology suggest that ambient temperature is one of the underlying triggers and potential causes of asthma. The aim of this study was to examine the impact and the molecular mechanism of temperature‐invoked airway inflammation using an experimental model of asthma in BALB/c mice. Methods Mice were exposed to different temperature conditions (steady 26°C, 26°C/18°C cycle, 26°C/10°C cycle) and received sensitization and challenge of ovalbumin (OVA) during a 21‐day period. HC030031, a selective transient receptor potential A1 (TRPA1) channel blocker, was used to investigate the underlying mechanism of TRPA1 in ‘asthmatic’ airways. After the final OVA challenge, in vivo lung function was measured, and bronchoalveolar lavage fluid (BALF) and pulmonary inflammation were assessed. Results The temperature variations, especially the largest temperature difference (16°C), exacerbated airway inflammation in OVA‐induced mice, increasing the levels of serum total‐IgE (immunoglobulin E) and IgG1, inflammatory cells and cytokines in BALF. Analysis of histopathological changes and lung function verified that repeated exposure to very cold and changed temperatures aggravated airway hyperresponsiveness (AHR). Significant upregulation of TRPA1 expression was revealed by immunohistochemistry in the presence of the largest temperature variation (26°C/10°C cycle), while administration of HC030031 successfully inhibited TRPA1 expression, thus attenuating the asthma‐like pathological features. Conclusion Repeated exposure to temperature variation exacerbated experimental ‘asthma’ and TRPA1 mediated this temperature‐dependent inflammatory effect.

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Section: Discussionmentioning

confidence: 95%

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Kang

Chen

et al. 2018

Respirology

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“…Similarly, four of six food‐allergic patients were polysensitized to food (Figure A). To further compare the humoral antifood response, we screened for the presence of food‐specific IgG4 . IgG4 reactivity against food antigens was common even in control subjects and did not distinguish between groups (Figure B).…”

Section: Resultsmentioning

confidence: 99%

Spontaneous food allergy in Was^−/− mice occurs independent of FcεRI‐mediated mast cell activation

Lexmond

Goettel

Sallis

et al. 2017

Allergy

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Background Food allergies are a growing health problem and the development of therapies that prevent disease onset is limited by the lack of adjuvant-free experimental animal models. We compared allergic sensitization in patients with food allergy or Wiskott-Aldrich syndrome (WAS) and defined whether spontaneous disease in Was−/− mice recapitulates the pathology of a conventional disease model and/or human food allergy. Methods Comparative ImmunoCAP ISAC microarray was performed in patients with food allergy or WAS. Spontaneous food allergy in Was−/− mice was compared to an adjuvant-based model in wild-type mice (WT-OVA/alum). Intestinal and systemic anaphylaxis was assessed and the role of the high affinity IgE Fc receptor (FcεRI) in allergic sensitization was evaluated using Was−/−Fcer1a−/− mice. Results Polysensitization to food was detected in both WAS and food allergic patients which was recapitulated in the Was−/− model. Oral administration of OVA in Was−/− mice induced low titers of OVA-specific IgE compared to the WT-OVA/alum model. Irrespectively, 79% of Was−/− mice developed allergic diarrhea following oral OVA challenge. Systemic anaphylaxis occurred in Was−/− mice (95%) with a mortality rate >50%. Spontaneous sensitization and intestinal allergy occurred independent of FcεRI expression on mast cells and basophils. Conclusions Was−/− mice provide a model of food allergy with the advantage of mimicking polysensitization and low food-antigen IgE titers as observed in humans with clinical food allergy. This model will facilitate studies on aberrant immune responses during spontaneous disease development. Our results imply that therapeutic targeting of the IgE/FcεRI activation cascade will not affect sensitization to food.

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“…A prospective study assessing CRD-guided diets in adults with EoE was thus initiated, but the trial was prematurely terminated due to a low response rate (7 %) at the interim analysis [68•]. Recent studies have demonstrated poor correlation between food CRD and sIgE assessment (ImmunoCAP) in patients with EoE [63•], possibly because of assay inhibition by IgG4 blocking antibodies [69], which further limits its use in designing elimination diets for EoE. These studies, however, were all based on one particular method of CRD (Immuno Solid-phase Allergen Chip, Thermo-Fisher/Phadia), and it is unclear if other methodologies would have similar limitations.…”

Section: Dietary Therapy In Eosinophilic Esophagitismentioning

confidence: 99%

“…Furthermore, dense infiltrates of IgG4-producing plasma cells have been identified in the deep lamina propria of the esophagus in patients with EoE [71•]. In this model, IgE may be produced in parallel with IgG4, as B cells that produce IgG4 can switch to producing IgE, but not vice versa [69]. These data recently prompted several authors to state that EoE is not an IgE-mediated food hypersensitivity [37], though the underlying immunologic pathophysiology remains unclear.…”

Section: Dietary Therapy In Eosinophilic Esophagitismentioning

confidence: 99%

Eosinophilic Esophagitis From an Allergy Perspective: How to Optimally Pursue Allergy Testing & Dietary Modification in the Adult Population

McGowan

Platts-Mills

2016

Curr Gastroenterol Rep

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Eosinophilic esophagitis (EoE) is a clinicopathologic condition characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation. In adults, the three most common treatment options are swallowed steroids, elimination diets, and periodic esophageal dilations. Many different elimination diets have been studied in adults, including elemental diets, allergy testing-directed diets, and empiric elimination diets. This article will review the existing data on these dietary therapies and will propose an approach to dietary management in adult EoE.

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The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response

Cited by 68 publications

References 51 publications

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Spontaneous food allergy in Was^−/− mice occurs independent of FcεRI‐mediated mast cell activation

Eosinophilic Esophagitis From an Allergy Perspective: How to Optimally Pursue Allergy Testing & Dietary Modification in the Adult Population

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The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response

Cited by 68 publications

References 51 publications

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma

Spontaneous food allergy in Was−/− mice occurs independent of FcεRI‐mediated mast cell activation

Eosinophilic Esophagitis From an Allergy Perspective: How to Optimally Pursue Allergy Testing & Dietary Modification in the Adult Population

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Spontaneous food allergy in Was^−/− mice occurs independent of FcεRI‐mediated mast cell activation