The developmental origins of placental function

Taylor, T.J.; Quinton, Ann; Hyett, Jonathan

doi:10.1002/ajum.12071

Cited by 3 publications

(2 citation statements)

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“…The timing of the maternal exposure to MCS is important, given that it is acknowledged that the first trimester of pregnancy is critical for placenta development [ 59 , 60 , 61 ]. The inflammatory response and oxidative environment caused by first trimester MCS exposure may result in poor placentation and inadequate uterine artery transformation and remodeling [ 62 , 63 ], which can contribute to placental dysfunction, characterized by impaired uteroplacental perfusion, chronic hypoxia and placental ischemia and finally can lead to PTB [ 64 , 65 , 66 ]. Thus, there appears to be plausible biological processes that may contribute to the first trimester of pregnancy being the sensitive period for prenatal MCS exposure causing PTB through placental dysfunction.…”

Section: Discussionmentioning

confidence: 99%

First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

Liu

Strodl

et al. 2022

IJERPH

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Mosquito coils are efficient mosquito repellents and mosquito coil smoke (MCS) contributes to indoor air pollution. However, no prior population-based study has investigated whether prenatal MCS exposure is a risk factor for preterm birth (PTB) and whether exposure to MCS in different trimesters of pregnancy is associated with different levels of risk. The sample involved 66,503 mother–child dyads. Logistic regression models were used to examine the relationships between prenatal MCS exposure during different trimesters of pregnancy and PTB. We found that prenatal MCS exposure was associated with a greater likelihood of PTB (OR = 1.12, 95%CI: 1.05–1.20). The prenatal MCS exposure during the first trimester was associated with 1.17 (95%CI: 1.09–1.25) times the odds of being PTB, which was higher than exposure during the second trimester (OR = 1.11, 95%CI: 1.03–1.19) and during the third trimester (OR = 1.08, 95%CI: 1.01–1.16). In the stratified analysis, prenatal MCS exposure significantly increased PTB risk among girls but not among boys. Our results indicated that maternal MCS exposure during pregnancy was associated with PTB and that the first trimester might be the sensitive period. In light of these findings, public health interventions are needed to reduce prenatal exposure to MCS, particularly during the first trimester of pregnancy.

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Section: Discussionmentioning

confidence: 99%

First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

Liu

Strodl

et al. 2022

IJERPH

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“…ŮƈƊƆƍżźƇƇƙ ƉƅźƐſƇƌƂ ƉƈƑƂƇźƝƌƖƋƙ żƀſ Ɓ ƆƈƆſƇƌƍ ƟƆƉƅźƇƌźƐƟƠ, Ƈź ƐƟƃ ƎźƁƟ żƟžŻƍżźƝƌƖƋƙ ƉƊƂƄƊƟƉƅſƇƇƙ ƌź ƟƇżźƁƟƙ ƌƊƈƎƈŻƅźƋƌź [6,17]…”

Section: ŝƌƌƍɖunclassified

Hormonal function of the fetoplacental complex in pregnant women with low-lying chorion

Pecheriaha¹,

Marynchyna²

2022

UJHW

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Purpose - to analyze the hormonal function of the fetoplacental complex in pregnant women with normal and low-lying chorion. Materials and methods. 50 pregnant women with a low-lying chorion (main group) and 50 pregnant women with a position of the chorion in the body and fundus of the uterus (control group) were involved in the laboratory examination. All examined women of the main group were divided into 2 subgroups, depending on the period of gestation (25 women at 5-8 weeks of gestation and 25 women at 9-12 weeks of gestation). According to these terms, the control group was also divided (25 women at 5-8 weeks of gestation and 25 women at 9-12 weeks of gestation). During pregnancy in the І trimester of pregnancy, the content of hormones in blood serum was determined: estradiol, chorionic gonadotropin, placental lactogen, progesterone. Results. Conducted research on the level of hormones in the blood serum of pregnant women showed that the concentration of estradiol in the main group was reduced throughout the І trimester of pregnancy. In particular, the content of this hormone was lower compared to the control by 7.2% in 5-8 weeks of gestation (p˃0.05), and by 23.9% - in 9-12 weeks (p<0.05). The content of progesterone in pregnant women with low-lying chorion, on average, was lower compared to the control group by 10.9% in the period of 5-8 weeks of pregnancy (p<0.05) and by 21.0% in the period of 9-12 weeks (p<0.05). It was also established that the level of placental lactogen in the blood serum of pregnant women at 9-12 weeks of gestation in the main group was probably lower compared to the control (p<0.05). Analyzing the content of chorionic gonadotropin, it is noted its significant decrease during the entire early period of gestation in the main group compared to the control, respectively: at 5-8 weeks of gestation - 36990.0±210.0 mg/l and 43270.0±226.0 ml/l (p<0.05); at 9-12 weeks - 37194.0±395.0 mg/l and 54700.55±525.0 ml/l (р<0.05). Conclusions. Pregnant women with low-lying chorion in the early stages of gestation had a much slower increase in hormone levels and lag in quantitative indicators was observed compared to pregnant women in which the chorion was located in the fundus and body of the uterus. This is evidence of hormonal dysfunction of the placenta, and therefore, a marker of the developing of placental dysfunction. A decrease in the levels of hormones of the fetoplacental complex in pregnant women with low placentation is manifested by clinical signs of early placental dysfunction in the form of a threat of termination of pregnancy, partial detachment of the chorion in the early term, spontaneous miscarriage and lead to further progression of placental dysfunction. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethic Committee of Bukovinian State Medical University. The informed consent of the patients was obtained for the conducting the studies. No conflict of interests was declared by the authors.

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Critical window for the association between prenatal environmental tobacco smoke exposure and preterm birth

Liu

Strodl

et al. 2022

Environmental Research

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The developmental origins of placental function

Cited by 3 publications

References 33 publications

First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth

Hormonal function of the fetoplacental complex in pregnant women with low-lying chorion

Critical window for the association between prenatal environmental tobacco smoke exposure and preterm birth

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