The diabetic syndrome in the tuco-tuco (Ctenomys talarum)

Wise, P. H.; Weir, Barbara J.; Hime, J. M.; Forrest, Ewan

doi:10.1007/bf01212256

Cited by 21 publications

(6 citation statements)

References 13 publications

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“…This comparison indicates that the concentrate diets used in the present study are more digestible than the diets plains viscachas probably have adapted to over evolution. The relevance of maintaining rodents susceptible to diabetic conditions on high‐fiber diets without concentrates has been repeatedly recommended in order to prevent obesity and diabetes, and this not only with respect to viscachas [Gull et al, ; Wenker et al, ] but also for degus [Edwards, ], tuco‐tucos ( Ctenomys talarum ) [Wise et al, ], agoutis ( Dasyprocta spp.) [McWilliams, ], and sand rats [Kalman et al, ].…”

Section: Discussionmentioning

confidence: 99%

Digestive physiology of the plains viscacha (Lagostomus maximus): A large herbivorous hystricomorph rodent

et al. 2015

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Plains viscachas (Lagostomus maximus) are large South American, fossorial rodents susceptible to diabetic cataracts. Various aspects of their digestive physiology were studied in three different experiments with 9 male and 7 female adult animals and 6 different diets (total n of feeding trials = 35). Viscachas achieved mean retention times of 23-31h, which is of a magnitude also recorded in horses; these did not differ for solute or small particle (<2mm) markers. Secondary marker excretion peaks indicated coprophagy, and were rarer on high-protein as compared to grass hay-only diets. Mean resting metabolic rate was, at 229 kJ/kg0.75/d, lower than expected for a mammal of this size. Digestible energy requirement for maintenance was 445 kJ/kg0.75/d. At 1.6-2.7 L/d, viscachas produced more methane than expected for a hindgut fermenter of their size. On diets that included concentrate feeds, viscachas excreted glucose in their urine, corroborating reports on the susceptibility of this species for diabetes when kept on energy-dense food. Viscachas had a similar apparent digestibility of protein, lipids, and macrominerals as other rodents, rabbits, or domestic horses. This suggests that whether or not a species practices coprophagy does not have a major influence on these measures. Viscachas resemble other hindgut fermenters in their high apparent calcium digestibility. With respect to a digestibility-reducing effect of dietary fiber, viscachas differed from rabbits and guinea pigs but were similar to horses, suggesting that small body size needs not necessarily be linked to lower digestive efficiency on high-fiber diets. three different experiments with 9 male and 7 female adult animals and 6 different diets (total 28 n of feeding trials = 35). Viscachas achieved mean retention times of 23-31h, which is of a 29 magnitude also recorded in horses; these did not differ for solute or small particle (<2mm) viscachas excreted glucose in their urine, corroborating reports on the susceptibility of this 36 species for diabetes when kept on energy-dense food. Viscachas had a similar apparent 37 digestibility of protein, lipids, and macrominerals as other rodents, rabbits, or domestic 38horses. This suggests that whether or not a species practices coprophagy does not have a 39 major influence on these measures. Viscachas resemble other hindgut fermenters in their high 40 apparent calcium digestibility. With respect to a digestibility-reducing effect of dietary fiber, 41 viscachas differed from rabbits and guinea pigs but were similar to horses, suggesting that 42 small body size needs not necessarily be linked to lower digestive efficiency on high-fiber 43 diets. 44 45

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Section: Discussionmentioning

confidence: 99%

Digestive physiology of the plains viscacha (Lagostomus maximus): A large herbivorous hystricomorph rodent

et al. 2015

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“…Howard found a high incidence of spontaneous diabetes mellitus in Macaca nigra (Celebes black apes) [103]. Diabetes mellitus signs include hyperglycemia, decreased clearance of glucose, in intravenous tolerance tests, reduced insulin secretion and increased serum lipids.…”

Section: Genetically Diabetic Animalsmentioning

confidence: 99%

Acute and chronic animal models for the evaluation of anti-diabetic agents

Kumar

Singh

Vasudeva

et al. 2012

Cardiovasc Diabetol

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Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern. Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure. Experimental diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic (immunological) manipulations. Most of the experiments in diabetes are carried out in rodents, although some studies are still performed in larger animals. The present review highlights the various methods of inducing diabetes in experimental animals in order to test the newer drugs for their anti-diabetic potential.

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“…Other comparable animals are: Spiny mouse (Acomys cahirinus, Acomy russatus) [23] and Tuco-tuco (Ctenomys talarum) [24].…”

Section: Normal Diabetic Animals (No Models)mentioning

confidence: 99%

Recommended Testing in Diabetes Research

Verspohl¹

2002

Planta med

102

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Diabetic disease is increasing rapidly and vast amounts of resources are spent in all countries. Thus, the screening of new compounds including plant extracts for antidiabetic effects is mandatory. In this review both simple assays [e.g., on blood glucose (after or without a glucose load), plasma insulin and extrapancreatic effects] are described as well as specific in vivo tests in diabetic animals and in vitro tests with respect to the mechanism of compounds. In total, approx. 30 selected tests are evaluated and references are given. Thus, the investigator is guided through the tests and is advised that measuring only one parameter such as glucose will not be sufficient. In the case that the financial resources are poor for the investigator, more than glucose still has to be measured. A balance is made by describing absolutely necessary investigations while concentrating on those at low cost. It has to be started with simple assays; to use one test only, however, means oversimplifying the diabetes disease; additionally antidiabetic effects may be missing. The investigator is guided through the advantages and limitations of diabetic animal models and is advised about specific in vitro tests to look at the mechanism of action. All investigators should profit from these details, not only the phytoresearchers.

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The diabetic syndrome in the tuco-tuco (Ctenomys talarum)

Cited by 21 publications

References 13 publications

Digestive physiology of the plains viscacha (Lagostomus maximus): A large herbivorous hystricomorph rodent

Digestive physiology of the plains viscacha (Lagostomus maximus): A large herbivorous hystricomorph rodent

Acute and chronic animal models for the evaluation of anti-diabetic agents

Recommended Testing in Diabetes Research

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