The Diagnosis and Classification of Parasitic Diseases of the Liver

Mandal, Shyamapada; Mandal, Manisha

doi:10.1007/978-3-319-02096-9_11

Cited by 2 publications

(2 citation statements)

References 72 publications

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“…Several of the pathologies associated with fluke and tapeworm infections are considered major neglected diseases affecting countries in the Americas, Asia, and Africa. Parasitic infections can remain asymptomatic for long periods, and symptoms are often misdiagnosed, making flatworm-associated diseases difficult to target and treat [5][6][7][8][9]. Very few pharmaceutical products are currently available for treatment and instances of parasite resistance and allergic reactions to these drugs have been reported [10].…”

Section: Introductionmentioning

confidence: 99%

Characterization of viruses in a tapeworm: phylogenetic position, vertical transmission, and transmission to the parasitized host

et al. 2020

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Parasitic flatworms (Neodermata) infect all vertebrates and represent a significant health and economic burden worldwide due to the debilitating diseases they cause. This study sheds light for the first time into the virome of a tapeworm by describing six novel RNA virus candidate species associated with Schistocephalus solidus, including three negative-strand RNA viruses (order Jingchuvirales, Mononegavirales, and Bunyavirales) and three double-stranded RNA viruses. Using in vitro culture of S. solidus, controlled experimental infections and field sampling, we demonstrate that five of these viruses are vertically transmitted, and persist throughout the S. solidus complex life cycle. Moreover, we show that one of the viruses, named Schistocephalus solidus rhabdovirus (SsRV1), is excreted by the parasite and transmitted to parasitized hosts indicating that it may impact S. solidus-host interactions. In addition, SsRV1 has a basal phylogenetic position relative to vertebrate rhabdoviruses suggesting that parasitic flatworms could have contributed to virus emergence. Viruses similar to four of the S. solidus viruses identified here were found in geographically distant S. solidus populations through data mining. Further studies are necessary to determine if flatworm viruses can replicate in parasitized hosts, how they contribute to parasite infection dynamics and if these viruses could be targeted for treatment of parasitic disease.

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Section: Introductionmentioning

confidence: 99%

Characterization of viruses in a tapeworm: phylogenetic position, vertical transmission, and transmission to the parasitized host

et al. 2020

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“…Color Doppler sonography shows the absence of vascular flow in the solid components of the lesions; this finding simplifies and clarifies diagnosis in many patients [9]. CT and MR imaging displays multiple irregular, ill-defined lesions scattered throughout the involved liver tissue [10,11]. On MR imaging, multiple small round cysts with a solid component or solid component surrounding large and/or irregular cysts with multiple round cysts are thought to be characteristic of and highly specific for alveolar echinococcosis of the liver [10].…”

Section: Discussionmentioning

confidence: 96%

Portal hypertension and cholestasis due to Echinococcus alveolaris: a case report

Seçkin¹,

Çağın²,

Yıldırım³

et al. 2016

Med-Science

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Alveolar ecchinococcosis (AE) is a rare but potentially life-threatening serious parasitic disease. The parasit may involve liver and, most importantly, expand vessels and biliary tract. We present here a case of esophageal variceal bleeding due to portal hypertension and cholestasis secondary to AE. We present the case of a 30-year-old female patient who was admitted to emergency service with hematemesis, melena and icter. Upper gastrointestinal endoscopy revealed gastroesophageal varices and portal gastropathy. Contrasted computerized tomography examination showed a solid calcific lesion (cross dimension 6x11 and 5x9 cm.) of biliary tracts causing dilatation. An USG guided biopsy from the mass was performed and histological examination revealed AE. We also review here the literature on portal hypertension and cholestasis due to Echinococcus alveolaris. AE is rare a disease and may cause severe complications. Endoscopic and percutaneous drainage for biliary obstruction caused by hepatic AE has a palliative effect even in the late stages. Liver transplantation was recommended but this operation was not performed for living donor shortage. Liver transplantation should be considered in the management of advanced liver alveolar echinococcosis.

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The Diagnosis and Classification of Parasitic Diseases of the Liver

Cited by 2 publications

References 72 publications

Characterization of viruses in a tapeworm: phylogenetic position, vertical transmission, and transmission to the parasitized host

Characterization of viruses in a tapeworm: phylogenetic position, vertical transmission, and transmission to the parasitized host

Portal hypertension and cholestasis due to Echinococcus alveolaris: a case report

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