The diagnosis and prognosis of early arthritis: Rationale for new prognostic criteria

Scott, David

doi:10.1002/art.10134

Cited by 53 publications

(44 citation statements)

References 22 publications

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“…The limited diagnostic value of the anti-CCP ELISA is, however, a misinterpretation by Scott rather than a result of the study, which demonstrated that the anti-CCP ELISA independently and significantly contributes to the performance of the predictive model (2). The odds ratios of the anti-CCP test are higher than those of the other 6 criteria of the model.…”

Section: To the Editormentioning

confidence: 73%

“…Scott states that the cases in our study (2) are highly selected, which is untrue. The patients with early arthritis were referred directly by local general practitioners, which makes our study population based.…”

Section: To the Editormentioning

confidence: 94%

“…In Table 1, Scott compares our diagnostic study (2), performed in unselected patients with early arthritis, with 2 prognostic studies in patients with rheumatoid arthritis (RA) (3,4). We believe that this comparison is not warranted and may be misleading.…”

Section: To the Editormentioning

confidence: 99%

“…Scott also states that our report (2) suggests that the anti-cyclic citrullinated peptide antibody (anti-CCP) enzymelinked immunosorbent assay (ELISA) has limited value as a diagnostic criterion for early RA. The limited diagnostic value of the anti-CCP ELISA is, however, a misinterpretation by Scott rather than a result of the study, which demonstrated that the anti-CCP ELISA independently and significantly contributes to the performance of the predictive model (2).…”

Section: To the Editormentioning

confidence: 99%

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The diagnosis and prognosis of early arthritis: Comment on the editorial by Scott

Visser¹,

Hazes²

2003

Arthritis & Rheumatism

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Section: To the Editormentioning

confidence: 73%

Section: To the Editormentioning

confidence: 94%

Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

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The diagnosis and prognosis of early arthritis: Comment on the editorial by Scott

Visser¹,

Hazes²

2003

Arthritis & Rheumatism

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“…Consequently, predicting the susceptibility to erosions or the early development of erosions is of major importance. Additionally, ϳ25% of patients with RA do not develop early erosions (43), and identifying this group may allow less aggressive therapy to be utilized. Some of us have previously demonstrated the utility of combining individual serum variables and deriving diagnostic algorithms (28).…”

Section: Discussionmentioning

confidence: 99%

Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: A potential marker of erosive joint destruction

Brown

Moore

Johnen

et al. 2007

Arthritis & Rheumatism

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Objective. The transforming growth factor ␤ superfamily member macrophage inhibitory cytokine 1 (MIC-1) is expressed upon macrophage activation, regulated by the p53 pathway, and linked to clinical events in atherosclerosis and cancer. Since rheumatoid arthritis (RA) shares similar etiopathologic mechanisms with the above diseases, we sought to determine the clinical utility of determining MIC-1 serum levels and MIC-1 genotype in the management of RA.Methods. Ninety-one RA patients were recruited. Serum was collected from 83 of these patients and synovial biopsy samples were collected from the remaining 8 patients. Of the 83 patients from whom serum was collected, 61 were treated on an outpatient basis (defined as having nonsevere disease), and 22 patients went on to undergo hemopoietic stem cell transplantation (HSCT) (defined as having severe disease).Results. Serum levels of MIC-1 were higher in RA patients and reflected disease severity independently of classic disease markers. MIC-1 was detected in rheumatoid synovial specimens, and allelic variation of MIC-1 was associated with earlier erosive disease and severe treatment-resistant chronic RA. Additionally, algorithms including serum and/or allelic variation in MIC-1 predicted response to HSCT, the presence of severe disease, and joint erosions.Conclusion. Determination of serum levels of MIC-1 and MIC-1 genotype may be clinically useful in the management of RA as well as in selection of patients for HSCT, since they predict disease course and response to therapy. The data indicate a potential role for MIC-1 in RA pathogenesis. These results warrant larger prospective studies to fully delineate and confirm a role for MIC-1 genotyping and serum estimation in patient selection for HSCT and in the management of RA.

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Serum IgA rheumatoid factor and pyridinoline in very early arthritis as predictors of erosion(s) at two years: A simple model of prediction from a conservatively treated community‐based inception cohort

Loët¹,

Brazier²,

Boumier³

et al. 2010

Arthritis Care & Research

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Objective. To identify, in conservatively treated, very early arthritis patients, predictors of >1 erosion(s) at 2 years, and to construct a prediction model. Methods. Community-based adults (n ‫؍‬ 310) who had never taken disease-modifying antirheumatic drugs (DMARDs) or steroids with swelling of >2 joints persisting for >4 weeks and lasting <6 months were recruited. Erosion status was assessed at 0, 6, 12, and 24 months; evaluations were comprised of clinical criteria (Disease Activity Score, Health Assessment Questionnaire), C-reactive protein level, erythrocyte sedimentation rate, autoantibodies, bone and cartilage markers, hand densitometry, and HLA class II shared epitopes. Patients meeting American College of Rheumatology rheumatoid arthritis (RA) criteria or with undifferentiated arthritis (UA) were followed and treated conservatively: one-third of RA patients and three-fourths of UA patients received no DMARDs during 2 years; a biologic agent was given to 1.8% of the patients during the first year. The main judgment criterion was >1 erosion(s) at 2 years. Results. At 2 years, 219 patients were assessed; 31.3% with RA and 10.6% with UA had >1 erosion(s). Logistic regression analysis at that time showed erosion(s) strongly associated with serum IgA rheumatoid factor (IgA-RF) and pyridinoline levels for the 190 patients with no baseline erosions, with the corresponding receiver operating characteristic curve having an area under the curve of 0.77 (95% confidence interval 0.64 -0.86). A prediction model was constructed with IgA-RF thresholds of 5 and 25 IU/ml and a pyridinoline threshold of 10 nM/liter; odds ratios ranged from 1 for IgA-RF <5 IU/ml and pyridinoline <10 nM/liter to 50.75 for the association of IgA-RF >5 IU/ml and pyridinoline >10 nM/liter. Conclusion. This model, using serum IgA-RF and pyridinoline concentrations, was able to predict >1 erosion(s) at 2 years in very early arthritis patients.

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The diagnosis and prognosis of early arthritis: Rationale for new prognostic criteria

Cited by 53 publications

References 22 publications

The diagnosis and prognosis of early arthritis: Comment on the editorial by Scott

The diagnosis and prognosis of early arthritis: Comment on the editorial by Scott

Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: A potential marker of erosive joint destruction

Serum IgA rheumatoid factor and pyridinoline in very early arthritis as predictors of erosion(s) at two years: A simple model of prediction from a conservatively treated community‐based inception cohort

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