The diagnosis and surgical management of juxtaglomerular cell tumor of the kidney

Abstract

Juxtaglomerular cell tumor (JCT) of the kidney is a rare benign renal neoplasm. Four cases of JCT of the kidney have been diagnosed and treated surgically in our hospital from January 2005 to August 2008. The clinical features, laboratory examination, imaging examination, pathological results and electron microscopy examination were analyzed, and a review of the literature was summarized. Three patients underwent open partial nephrectomy, and one patient underwent laparoscopic partial nephrectomy. Pathological examination confirmed the final diagnosis of JCT of the kidney. The blood pressure, potassium, renin and aldosterone remained within the normal range after surgery. JCT of the kidney should be kept in mind because they represent a surgically curable cause of secondary hypertension. Nephron-sparing surgery is recommended.

Advantages of renin inhibition in a patient with reninoma

“…However, MRI provided misleading findings and the diagnosis of reninoma was delayed with progressive impairment of blood pressure control and worsening of hypokalemia. On the contrary, this case confirms that CT scans may be particularly sensitive at detecting the tumor [1,3,4,9]. In the presence of a high clinical suspicion, CT scans should be performed in addition to MRI to improve the chance of a correct diagnosis.…”

“…It represents a rare case of surgically correctable hypertension [1]. The diagnosis remains challenging because of ambiguities in the interpretation of biochemical and radiological data.…”

Review of juxtaglomerular cell tumor with focus on pathobiological aspect

“…The complete tumor resection by radical or partial nephrectomy is the best modality for JGCT [35,53]. Antihypertensive agents should be treated for hypertension until accurate diagnosis is made, but blood pressure, plasma renin level usually normalize after the nephrectomy in most cases with JGCT [2,23,25,54-56].…”

Juxtaglomerular Cell Tumor that was Preoperatively Diagnosed Using Selective Renal Venous Sampling

“…Regarding the surgical management of JCTs, laparoscopic tumor resection or partial nephrectomy have recently been recommended because JCTs are not only usually benign and small, but also often located on the surface of the kidneys and can be easily removed (22,23). However, in our case, the tumor was too small and entirely endophytic to detect its location during laparoscopy.…”