The Diagnosis of Different Degrees of Lead Absorption; In Special References to Choice and Evaluation of Various Parameters Indicative of an Increased Lead Absorption

Wada, Osamu; Yano, Yuzo; Ono, Tetsu; Toyokawa, Kôhei

doi:10.2486/indhealth.11.55

Cited by 10 publications

(16 citation statements)

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“…Trials were made to simulate the approaches taken by previous authors 6,7,9) to identify the Pb-B concentrations at which the proportion of the subjects with ALA-U above a given concentration (e.g., 10 mg/l) begins to increase. For this purpose, men and women, separately, were classified by 5 µg/100 ml Pb-B ranges (e.g., <15 to 20 µg/100 ml) and the proportion (in %) of the subjects with >10 mg/l ALA-U 7) were calculated for each range.…”

Section: Pb-b At Which the Proportion Of The Subjects With Elevated Amentioning

confidence: 99%

“…The calculation gave 35 and 30 µg/100 ml Pb-B for men and women, respectively. The same analysis was applied also to the cases 6 , where X is Pb-B (µg/100 ml) and Y is ALA-U (mg/l); for the numbers of subjects, see Table 1.…”

Section: Pb-b At Which the Proportion Of The Subjects With Elevated Amentioning

confidence: 99%

“…Accordingly, the Pb-B concentration to induce a substantial increase in ALA-U has also been a focus of interest. The lowest Pb-B concentration to induce an increase in ALA-U, or the threshold Pb-B level, has also been discussed as early as mid-1970s [6][7][8][9] . The Pb-B values cited by various authors were 16 10) , 35 6) , 25 to 34 7) or 48 µg/100 ml 9) .…”

Section: Introductionmentioning

confidence: 99%

“…The lowest Pb-B concentration to induce an increase in ALA-U, or the threshold Pb-B level, has also been discussed as early as mid-1970s [6][7][8][9] . The Pb-B values cited by various authors were 16 10) , 35 6) , 25 to 34 7) or 48 µg/100 ml 9) . Whereas the criterion for setting the threshold Pb-B concentration was different among the authors, it appears that these Industrial Health 2000, 38, [181][182][183][184][185][186][187][188] proposed values of 25 to 50 µg/100 ml Pb-B have been accepted since then without major criticism from experiences in occupational health, although reports are also available to suggest that an increase in ALA-U may take place at lower Pb-B [10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

“…Whereas the criterion for setting the threshold Pb-B concentration was different among the authors, it appears that these Industrial Health 2000, 38, [181][182][183][184][185][186][187][188] proposed values of 25 to 50 µg/100 ml Pb-B have been accepted since then without major criticism from experiences in occupational health, although reports are also available to suggest that an increase in ALA-U may take place at lower Pb-B [10][11][12][13][14] . The purpose of the present study is to elucidate the relationship of ALA-U with Pb-B, to examine the validity of the proposed Pb-B values [6][7][8][9][10][11][12][13][14] through a statistical approach, and to identify the threshold Pb-B concentration to induce elevation in ALA-U.…”

Section: Introductionmentioning

confidence: 99%

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Blood Lead Level to Induce Significant Increase in Urinary .DELTA.-Aminolevulinic Acid Level among Lead-Exposed Workers. A Statistical Approach.

et al. 2000

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The present study was initiated to examine the quantitative relationship between blood lead (Pb-B) and urinary δ δ δ δ δ-aminolevulinic acid (ALA-U) among Pb-exposed workers, and to find a threshold Pb-B level to induce an increase in ALA-U. For this purpose, pairs of venous blood and spot urine samples were collected from 8,274 men and 5,856 women (14,130 workers in total) who were occupationally exposed to inorganic lead. The blood and urine samples were analyzed for Pb-B and ALA-U by atomic absorption spectrometry and colorimetry, respectively, and the correlation between pairs of measures were subjected to statistical analysis. The assumption of the 3rd degree regression for correlation gave a substantially greater correlation coefficient (0.645 for men and 0.619 for women) than 1st or 2nd degree regression, whereas only very small improvement in the coefficient was achieved with 4th to 6th degree ones. Logarithmic conversion of the parameters was not effective in improving the correlation. The assumption of the 3rd degree regression followed by calculation of the local minimum gave 22, 29 and 23 µg/100 ml Pb-B for men, women, and men+women, respectively, as the threshold Pb-B to induce ALA-U increase. Pb-B to elevate ALA-U to the 95% upper normal limit (8 mg/l, common to men and women) was 62, 50 and 58 µg/100 ml for men, women and men+women, respectively. The validity of the 3rd degree regression assumption as a tool to calculate a threshold from experimental or epidemiological data is discussed.

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Section: Pb-b At Which the Proportion Of The Subjects With Elevated Amentioning

confidence: 99%

Section: Pb-b At Which the Proportion Of The Subjects With Elevated Amentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Blood Lead Level to Induce Significant Increase in Urinary .DELTA.-Aminolevulinic Acid Level among Lead-Exposed Workers. A Statistical Approach.

et al. 2000

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Reassessment of the threshold of the blood lead level to increase urinary δ-aminolevulinic acid based on their relationship in recent lead workers in Japan

Ono

Horiguchi

2021

Journal of Occupational Health

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Objectives The present study investigated the quantitative relationship between blood lead (Pb‐B) and urinary δ⁻aminolevulinic acid (ALA‐U) in lead workers, and examined the Pb‐B level that induces increases in ALA‐U and the corresponding ALA‐U. Methods We collected 10 562 data sets on Pb‐B, ALA‐U, age, and smoking habits from 808 workers (771 males and 37 females) who underwent multiple lead poisoning medical examinations at a lead‐acid battery and lead smelting plant in Japan between 1995 and 2018. Females were excluded, and data collected in 169 subjects prior to engaging in lead work were used as the control. Pb‐B and ALA‐U levels were measured by graphite furnace atomic absorption spectrophotometry and high‐performance liquid chromatography respectively. Results A significant dose‐response relationship was observed between Pb‐B and ALA‐U based on Pb‐B‐classified observations of increases in ALA‐U values and the prevalence of over‐reference ALA‐U as well as regression analyses independent of smoking habits. The results obtained revealed that the threshold of Pb‐B to increase ALA‐U was 25.1‐35.0 µg/dL based on the significant elevation point of the prevalence of over‐reference ALA‐U and 16.2‐22.3 µg/dL from a 3rd degree regression equation. Conclusions We proposed a threshold of Pb‐B to increase ALA‐U of 20 µg/dL and a biologically acceptable value of ALA‐U of 1 mg/L, corresponding to the threshold.

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Lead toxicity in the pregnant rat

Hayashi

1983

Environmental Research

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The Diagnosis of Different Degrees of Lead Absorption; In Special References to Choice and Evaluation of Various Parameters Indicative of an Increased Lead Absorption

Cited by 10 publications

References 1 publication

Blood Lead Level to Induce Significant Increase in Urinary .DELTA.-Aminolevulinic Acid Level among Lead-Exposed Workers. A Statistical Approach.

Blood Lead Level to Induce Significant Increase in Urinary .DELTA.-Aminolevulinic Acid Level among Lead-Exposed Workers. A Statistical Approach.

Reassessment of the threshold of the blood lead level to increase urinary δ-aminolevulinic acid based on their relationship in recent lead workers in Japan

Lead toxicity in the pregnant rat

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