The Diagnosis of Interstitial Cystitis Revisited: Lessons Learned From the National Institutes of Health Interstitial Cystitis Database Study

Hanno, Philip M.; Landis, J. Richard; Matthews-Cook, Yvonne; Kusek, John W.; Nyberg, Leroy

doi:10.1016/s0022-5347(01)61948-7

Cited by 420 publications

(204 citation statements)

References 11 publications

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“…This symptom scale is identical to the International Prostate Symptom Score (IPSS) (without the quality of life question) [14]. Painful bladder syndrome (PBS) was considered to be present if the respondent had its cardinal symptoms [15] of pain increasing as the bladder fills and/or pain relieved by urination (fairly often, usually, almost always) lasting for at least three months. Urinary incontinence (UI) was said to be present if the respondent reported involuntary loss of urine at least weekly [16].…”

Section: Urologic and Sexual Symptomsmentioning

confidence: 99%

Beyond the Lower Urinary Tract: The Association of Urologic and Sexual Symptoms with Common Illnesses

et al. 2007

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Objective-In addition to being prevalent and bothersome, urologic and sexual symptoms may be related to chronic medical illnesses. We investigate the relationship between ten urologic and sexual symptoms and four major illnesses (type II diabetes, cardiac disease, hypertension, and depression).Methods-We analyze data from the Boston Area Community Health (BACH) Survey, a community-based epidemiologic study of urologic symptoms and risk factors. BACH used a twostage stratified cluster sampling design to recruit 5,506 adults aged 30-79 (2,301 men, 3,205 women; 1,770 Black, 1,877 Hispanic, and 1,859 White respondents).Results-In bivariate analyses, most urologic and sexual symptoms are associated with type II diabetes, cardiac disease, hypertension, and depression. However, in multivariate models adjusting for all four illnesses, gender, race/ethnicity, age, alcohol intake, smoking, physical activity, and body mass index there were fewer significant associations. We found that all urologic symptoms were significantly related to at least one illness, with depression increasing the odds of all urologic and sexual symptoms studied.Conclusions-Urinary tract specialists may need to give greater weight to consideration of factors outside the urinary tract that may be contributing to urologic symptoms. It remains unknown whether treatment of medical and psychological illnesses can result in meaningful improvement in urologic symptoms, or conversely, whether urinary tract symptoms can provide valuable insight into an individual's overall health status. Keywords epidemiology; diabetes; hypertension; cardiac disease; depression; lower urinary tract symptoms; painful bladder syndrome; urinary incontinence; prostatitis; overactive bladder; frequency; urgency; nocturia; erectile dysfunction; female sexual dysfunction Corresponding author: Dr. Carol L. Link, New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA, Telephone: (1) 617-923-7747, Fax: (1) 617-926-8246, clink@neriscience.com. Take-home message Urological and sexual symptoms are significantly associated with depression, and to a lesser extent with cardiac disease, type II diabetes, and hypertension. Providers may need to look beyond the bladder and lower urinary tract to understand and/or treat presenting symptoms.

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Section: Urologic and Sexual Symptomsmentioning

confidence: 99%

Beyond the Lower Urinary Tract: The Association of Urologic and Sexual Symptoms with Common Illnesses

et al. 2007

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“…Even in those patients finding a volunteer was a challenge that would be more difficult when looking for healthy controls. The same limitation in the number of PBS/IC patients was found because the necessity of normalizing their selection for research restricts in up to 60% of those with clinically PBS/IC (35). There may also have had some bias in patient selection because our hospital is a tertiary referral for IC/ PBS.…”

Section: Discussionmentioning

confidence: 86%

Evaluation of the metabolism of glycosaminoglycans in patients with interstitial cystis

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Introduction: Painful bladder syndrome/interstitial cystitis (PBS/IC) pathogenesis is not fully known, but evidence shows that glycosaminoglycans (GAG) of bladder urothelium can participate in its genesis. The loss of these compounds facilitates the contact of urine compounds with deeper portions of bladder wall triggering an inflammatory process. We investigated GAG in urine and tissue of PBS/IC and pure stress urinary incontinence (SUI) patients to better understand its metabolism. Materials and Methods: Tissue and urine of 11 patients with PBS/IC according to NIDDK criteria were compared to 11 SUI patients. Tissue samples were analyzed by histological, immunohistochemistry and immunofluorescence methods. Statistical analysis were performed using t Student test and Anova, considering significant when p < 0.05. Results: PBS/IC patients had lower concentration of GAG in urine when compared to SUI (respectively 0.45 ± 0.11 x 0.62 ± 0.13 mg/mg creatinine, p < 0.05). However, there was no reduction of the content of GAG in the urothelium of both groups. Immunofluorescence showed that PBS/IC patients had a stronger staining of TGF-beta, decorin (a proteoglycan of chondroitin/dermatan sulfate), fibronectin and hyaluronic acid. Conclusion: the results suggest that GAG may be related to the ongoing process of inflammation and remodeling of the dysfunctional urothelium that is present in the PBS/IC.

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“…on unter einem Druck von 80 -100 cm H2O für ein bis 2 Minuten vor mit einer Wiederholung [5]. Das japanische Interstitial Cystitis Guideline Committee beschreibt die Technik der Hydrodistension wie folgt: Unter Spinalanästhesie Füllung der Blase bis 80 cm H2O Druck unter ständiger zystoskopischer Kontrolle bis max 800 -1000 ml und Ablassen der Fül-lung unter optischer Kontrolle [6].…”

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Hydrodistension der Harnblase zur Diagnostik und Therapie

Kaftan

Wiedemann

2018

Aktuel Urol

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The Diagnosis of Interstitial Cystitis Revisited: Lessons Learned From the National Institutes of Health Interstitial Cystitis Database Study

Abstract: The NIDDK criteria are too restrictive to be used by clinicians as the diagnostic definition of interstitial cystitis.

Cited by 420 publications

References 11 publications

Beyond the Lower Urinary Tract: The Association of Urologic and Sexual Symptoms with Common Illnesses

Beyond the Lower Urinary Tract: The Association of Urologic and Sexual Symptoms with Common Illnesses

Evaluation of the metabolism of glycosaminoglycans in patients with interstitial cystis

Hydrodistension der Harnblase zur Diagnostik und Therapie

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