The diagnosis of Kawasaki disease among Nigerian children: a nightmare for the caregivers and the doctors

Animasahun, Barakat Adeola; Adekunle, Motunrayo Oluwabukola; Kusimo, Olusola Yejide; Fadipe, Chineze

doi:10.21037/jphe.2017.06.06

Cited by 9 publications

(4 citation statements)

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“… 11 Verdoni et al 5 documented a 30-fold increase in cases of KD in Italy since the onset of the COVID-19 pandemic. This increase was similar to the recent exponential rise in the prevalence of this Kawasaki like disease seen in Lagos, Nigeria since the onset of the pandemic compared to the prevalence documented in a previous study 25 in the same geographical location over a five-year period between 2011 and 2016. The upsurge of cases of this Kawasaki-like disease during the pandemic likely supports its temporal association with COVID-19 infection and is further supported by the monthly variation in frequency of cases akin to the waves of the pandemic.…”

Section: Discussionsupporting

confidence: 84%

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

et al. 2022

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Section: Discussionsupporting

confidence: 84%

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

et al. 2022

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“…Incidence of Kawasaki disease is high in east Asian countries but reported all around the world. Fewer cases have been reported from Africa [11] and Latin [20].…”

Section: Epidemiologymentioning

confidence: 99%

Treatment Options for Refractory Kawasaki Disease

Oli¹,

Lu²,

Khati³

2020

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Kawasaki Disease (KD) is a self-limiting systemic vasculitis common among children under five years of age. Diagnosis of the disease is made primarily from the clinical features presented during the illness. Coronary artery aneurysm (CAA) is the main complication of this disease which can be prevented largely by the early diagnosis and administration of IVIG (Intravenous Immunoglobulin). Even with first dose of IVIG up to 10% -20% of patients develop refractory Kawasaki Disease, i.e., remain unresponsive to initial IVIG treatment. Second dose of IVIG is recommended treatment for refractory Kawasaki Disease but other alternative treatments are also being considered to lower the risk of complications. Different drugs are still in trial phase and some others have limited studies on larger population. Most of the study reports that involved newer drugs have limited patients or are from single centers which are very hard to apply to larger population. We will review general treatment approach in refractory Kawasaki disease.

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“…(Webb et al, 2020). It has been previously observed that very few cases of KD have been reported from Nigeria, with four separate reports documenting only 10 cases since 2010 (Animasahun et al, 2017). With the global trend of higher prevalence of MIS-C in children of African ancestry, enhanced surveillance and awareness for this syndrome in children with COVID-19 in Africa are therefore important.…”

Section: Introductionmentioning

confidence: 99%

Multisystem inflammatory syndrome (MIS-C) in an adolescent Nigerian girl with COVID-19: A call for vigilance in Africa

Onyeaghala¹,

Alasia²,

Eyaru³

et al. 2021

International Journal of Infectious Diseases

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Most reports of Multisystem Inflammatory Syndrome (MIS-C) have come from Europe and North America. The paucity of reports in Africa is in contrast with the demographics of the series in New York, Paris and UK with children of African ancestry accounting for over 40%, of all cases of MIS-C. With the global trend of higher prevalence of MIS-C in children of African ancestry, enhanced surveillance and awareness for this syndrome in children with COVID-19 in Africa are therefore important. A case report of a 12-year old Nigerian girl with MIS-C is presented in line with the WHO global surveillance especially in areas were MIS-C is considered a rarity. This case report stimulates a call for vigilance and expanded effort at surveillance to promote early recognition and diagnosis of MIS-C in Nigeria and Africa. The favourable outcome and experience from this case will create awareness, expand knowledge, and support clinicians in Nigeria and the African continent in their approach to other potential cases.

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The diagnosis of Kawasaki disease among Nigerian children: a nightmare for the caregivers and the doctors

Cited by 9 publications

References 0 publications

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

Treatment Options for Refractory Kawasaki Disease

Multisystem inflammatory syndrome (MIS-C) in an adolescent Nigerian girl with COVID-19: A call for vigilance in Africa

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