The diagnosis of ovarian cancer by pathologists: How often do diagnoses by contributing pathologists agree with a panel of gynecologic pathologists?

Tyler, Carl W.; Lee, Nancy C.; Robboy, Stanley J.; Kurman, Robert J.; Paris, Allen; Wingo, Phyllis A.; Williamson, G. David

doi:10.1016/0002-9378(91)90628-5

Cited by 44 publications

(13 citation statements)

References 10 publications

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“…Moreover, there was a 61.7% complete histopathologic agreement with only 1% of cases that were considered as having major differences. Similarly, Tyler et al (1991) performed slide reviews on 477 women diagnosed with ovarian, breast, or endometrial cancer and compared the diagnoses of pathologists contributing to tumour registries affiliated with the SEER program to an expert panel of three gynaecologic pathologists. They found an overall agreement of 97% for overall cancers, and the agreement for major cellular subtypes of ovarian cancer was 73% for endometrioid and 100% for clear cell cancers.…”

Section: Discussionmentioning

confidence: 99%

Ovarian cancer in younger vs older women: a population-based analysis

et al. 2006

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To compare the clinico-pathologic prognostic factors and survival of younger vs older women diagnosed with epithelial ovarian cancer. Demographic, clinico-pathologic, treatment, and surgery information were obtained from patients with ovarian cancer from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001 and analysed using Kaplan -Meier estimates. Of 28 165 patients, 400 were o30 years (very young), 11 601 were 30 -60 (young), and 16 164 were 460 (older) years of age. Of the very young, young, and older patients, 261 (65.3%), 4664 (40.2%), and 3643 (22.5%) had stage I -II disease, respectively (Po0.001). Across all stages, very young women had a significant survival advantage over the young and older groups with 5-year disease-specific survival estimates at 78.8% vs 58.8 and 35.3%, respectively (Po0.001). This survival difference between the age groups persists even after adjusting for race, stage, grade, and surgical treatment. Reproductive age (16 -40 years) women with stage I -II epithelial ovarian cancer who received uterine-sparing procedures had similar survivals compared to those who underwent standard surgery (93.3% vs 91.5%, P ¼ 0.26). Younger women with epithelial ovarian cancer have a survival advantage compared to older patients.

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Section: Discussionmentioning

confidence: 99%

Ovarian cancer in younger vs older women: a population-based analysis

et al. 2006

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“…To determine if there are significant discrepancies between registry and referral pathologists, Piver et al (2000), reviewed slides from a large cancer registry and found only 1% of cases had major differences with regard to either site of origin or histopathologic type. Similarly, Tyler et al (1991) performed slide reviews on 477 women diagnosed with ovarian cancer and compared the diagnoses of pathologists contributing to tumour registries affiliated with the SEER program to an expert panel of three gynecologic pathologists and found and overall agreement of 97%.…”

Section: Discussionmentioning

confidence: 99%

Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers

Cheung²,

et al. 2006

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To compare the survival of women with uterine papillary serous carcinoma (UPSC) and clear cell carcinoma (CC) to those with grade 3 endometrioid uterine carcinoma (G3EC). Demographic, pathologic, treatment, and survival information were obtained from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Data were analysed using Kaplan -Meier and Cox proportional hazards regression methods. Of 4180 women, 1473 had UPSC, 391 had CC, and 2316 had G3EC cancers. Uterine papillary serous carcinoma and CC patients were older (median age: 70 years and 68 vs 66 years, respectively; Po0.0001) and more likely to be black compared to G3EC (15 and 12% vs 7%; Po0.0001). A higher proportion of UPSC and CC patients had stage III -IV disease compared to G3EC patients (52 and 36% vs 29%; Po0.0001). Uterine papillary serous carcinoma, CC and G3EC patients represent 10, 3, and 15% of endometrial cancers but account for 39, 8, and 27% of cancer deaths, respectively. The 5-year disease-specific survivals for women with UPSC, CC and G3EC were 55, 68, and 77%, respectively (Po0.0001). The survival differences between UPSC, CC and G3EC persist after controlling for stage I -II (74, 82, and 86%; Po0.0001) and stage III -IV disease (33, 40, and 54; Po0.0001). On multivariate analysis, more favourable histology (G3EC), younger age, and earlier stage were independent predictors of improved survival. Women with UPSC and CC of the uterus have a significantly poorer prognosis compared to those with G3EC. These findings should be considered in the counselling, treating and designing of future trials for these high-risk patients.

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“…However, prior studies have performed reviews of slides from cancer registries and showed excellent agreement between registry and referral pathologists. 28,29 In fact, when Piver et al 28 reviewed slides from a large cancer registry, researchers found a 95.3% agreement between pathological diagnosis and accurate disease site of origin.…”

Section: Ajogorgmentioning

confidence: 99%