The diagnosis of primary eosinophilic oesophagitis in adults: missed or misinterpreted?

Kanakala, Venkatesh; Lamb, Christopher A; Haigh, Chris; Stirling, R W

doi:10.1097/meg.0b013e32832c7709

Cited by 36 publications

(26 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are also reports in the literature that the rising incidence of EoE is associated with increasing biopsy rates and that the diagnosis of EoE is still being missed or misinterpreted [65]. It was shown that diagnostic failure is frequently due to a delayed request for endoscopy in patients with dysphagia, poor recognition of typical endoscopic appearances of EoE, and failed recognition or recording of maximal eosinophil concentrations within biopsies [66]. This indicates that in spite of established consensus recommendations for the diagnosis of EoE, health care professionals such as gastroenterologists, allergists, general practitioners and pathologists who encounter EoE need to increase the awareness to facilitate diagnosis of this still relatively new disease.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Eosinophilic Esophagitis

Hrúz¹

2014

Dig Dis

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is an allergy-associated disease defined clinically by esophagus-related symptoms in combination with a dense esophageal eosinophilia, both of which are unresponsive to prolonged acid suppression with proton pump inhibitors. Over the last two decades EoE has increasingly been recognized in various geographical areas (mostly industrialized countries) with high socioeconomic development. The prevalence rate is increasing and reaches up to 50 patients per 100,000 inhabitants in some indicator regions. Whether this increased prevalence is due to a real increase in incidence, a result of increased awareness by health care providers or because of the nonfatal nature of EoE adding more and more cases to the patient pool is still a matter of controversy. Several studies have consistently demonstrated a male predominance in EoE, with a male-to-female risk ratio of 3:1. The average age at diagnosis ranges between 30 and 50 years and suggests that EoE is a disease of the middle-aged man. It can affect patients of every race, but the disease is more common among Caucasians. In both children and adults, EoE has been clearly associated with allergies to food and aeroallergens, and most EoE patients present with a personal allergic background (e.g. asthma, rhinoconjunctivitis or oral allergy syndrome). In conclusion, knowledge of epidemiologic parameters of EoE is crucial for identifying risk factors as well as pathogenic mechanisms, planning preventive measures and determining optimal treatment strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiology of Eosinophilic Esophagitis

Hrúz¹

2014

Dig Dis

View full text Add to dashboard Cite

show abstract

“…White exudates histologically correspond to eosinophilic microabscesses with the aggregation of a couple of eosinophils [83], which grossly resemble esophageal candidiasis (Fig. 3) [84,85]. The esophageal mucosa appears to be thick and whitish, owing to the marked inflammation and edema, resulting in decreased or missed vascularity, often observed in GERD.…”

Section: Endoscopic Findingsmentioning

confidence: 97%

Diagnosis and treatment of eosinophilic esophagitis in clinical practice

Abe

Sasaki

Yagi

et al. 2017

Clin J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Case series now being collated include >10,000 patients in the USA [15][16][17][18][19][20][21][22][23] .…”

Section: Pathophysiologymentioning

confidence: 99%

“…It is still not clear why EoE presents in these different phenotypes or whether they signify a different prognosis or disease pattern of responsiveness to therapy. During the years 2004-2006, 8 additional case series were described in multiple geographic locations ( table 1 ) [16][17][18][19][20][21][22][23] . The total number of patients remained small, amounting to <300 reported patients, until after 2007 when case series with >300 patients began to appear.…”

Section: Introductionmentioning

confidence: 99%