The diagnosis of sarcopenia is mainly driven by muscle mass in hemodialysis patients

Bataille, Stanislas; Serveaux, Marianne; Carreño, E.M. García; Pedinielli, Nathalie; Darmon, Patrice; Robert, Alain

doi:10.1016/j.clnu.2016.10.016

Cited by 85 publications

(72 citation statements)

References 34 publications

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“…In a cross‐sectional study, CI was significantly correlated with skeletal muscle mass measured by BIA . However, CI could not predict sarcopenia but was correlated with muscle strength in HD patients . Thus, creatinine represents an important marker of functional muscle mass but not the whole muscle mass.…”

Section: Discussionmentioning

confidence: 85%

“…CI is a useful nutritional parameter reflecting dietary protein intake and skeletal muscle mass of the patient . CI measures true muscle degradation and reflects true Lean body mass (LBM) even in edematous conditions .…”

Section: Discussionmentioning

confidence: 99%

“…Low values of CI (<15.2) were significantly associated with all‐cause mortality . CI cutoff values to predict sarcopenia varied considerably in men and women at 17.6 and 15.5, respectively . Nutritional diagnosis is based on etiology, evidence, and signs and symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…CI is a useful nutritional parameter reflecting dietary protein intake and skeletal muscle mass of the patient. 4,13 CI measures true muscle degradation and reflects true Lean body mass (LBM) even in edematous conditions. 14 Low muscle mass is an indicator of PEW and malnutrition inflammation syndrome, and is significantly correlated with higher mortality in dialysis patients.…”

Section: Discussionmentioning

confidence: 99%

“…16 However, CI could not predict sarcopenia but was correlated with muscle strength in HD patients. 13 Thus, creatinine represents an important marker of functional muscle mass but not the whole muscle mass. We believe that prediction of muscle mass based on serum creatinine…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Hwang

Cho

et al. 2018

Hemodialysis International

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Hwang

Cho

et al. 2018

Hemodialysis International

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show abstract

Sarcopenia and Other Chronic Organ Diseases

Arai

2021

Sarcopenia

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Myosteatosis as an independent risk factor for mortality after kidney allograft transplantation: a retrospective cohort study

Morel

Ouamri

Canouï‐Poitrine

et al. 2021

J cachexia sarcopenia muscle

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Background Patients with end-stage renal disease may display both a loss of skeletal muscle mass and an increase in muscle fat deposits. We aimed to analyse the impact of low skeletal muscle mass index (SMI, surrogate marker of sarcopenia) and low muscle density (MD, surrogate marker of myosteatosis) on patient survival after kidney transplantation (KT). Methods In a retrospective cohort of 200 kidney transplant recipients (KTr), we measured on an unenhanced cross-sectional computed tomography scan taken at the level of the third lumbar vertebra within the previous year or at the time of KT, both SMI (muscle cross-sectional area normalized for height 2 , reported in cm 2 /m 2 ) and MD (mean attenuation of muscle cross-sectional area, expressed in Hounsfield units). We determined age-specific and sex-specific normality thresholds on 130 healthy subjects. The baseline factors associated with low MD were assessed by logistic regression analysis. Cox proportional hazard univariable and multivariable models were constructed to identify predictive factors of patient survival. Results Among the 200 patients of the cohort, 123 were male (62%), and mean age was 54.8 ± 13.8 years. A total of 181 KTr required renal replacement therapy before KT (91%), and 36 KTr (18%) received repeat kidney transplant after previous failed KT. Mean MD was 30.6 ± 9 HU in men and 29.7 ± 8.3 HU in women, whereas SMI was 49.7 ± 8.6 cm 2 /m 2 in men and 42.3 ± 7.3 cm 2 /m 2 in women. MD was below the 2.5th percentile for the healthy population in 49 KTr (25%), defining the myosteatosis group, while SMI was below the 2.5th percentile for the reference population in 10 KTr (5%). Independent risk factors for myosteatosis were two or more KT [adjusted odds ratio (aOR) 5.2, 95% confidence interval (95% CI): 2.22-12.4, P = 0.0001], a history of stroke (aOR 3.7, 95% CI: 1.30-10.7, P = 0.015), and body mass index > 25 kg/m 2 (aOR 2.94, 95% CI: 1.4-6.18, P = 0.004). Myosteatosis was independently associated with mortality [adjusted hazard ratio (aHR) 2.12, 95% CI: 1.06-4.24, P = 0.033], as were cardiovascular disease (HR 2.06, 95% CI: 1.02-4.15, P = 0.043) and age (aHR 1.06, 95% CI: 1.03-1.09, P = 0.0003). Low SMI was not associated with mortality. Conclusions Myosteatosis, which was more prevalent than low skeletal muscle mass, might be an important prognostic marker in patients undergoing KT.

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The diagnosis of sarcopenia is mainly driven by muscle mass in hemodialysis patients

Cited by 85 publications

References 34 publications

Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Sarcopenia and Other Chronic Organ Diseases

Myosteatosis as an independent risk factor for mortality after kidney allograft transplantation: a retrospective cohort study

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