The diagnostic accuracy and strength of agreement between endoscopic ultrasound and histopathology in the staging of ampullary tumors

Wee, Eric; Lakhtakia, Sandeep; Gupta, Rajesh; Sekaran, Anuradha; Shetty, Mahesh; Kalapala, Rakesh; Monga, Amitabh; Arjunan, Saravanan; Rebala, Pradeep; Ramchandani, Mohan; Rao, Guduru Venkat; Reddy, D. Nageshwar

doi:10.1007/s12664-012-0248-3

Cited by 16 publications

(34 citation statements)

References 25 publications

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“…Among these, 14 studies ( n = 422) that met the inclusion criteria were included in the present analysis. All of the 14 studies were published as full‐text articles in peer‐reviewed journals . Not all studies provided data for all sections; we used the available data for ampullary tumor only.…”

Section: Resultsmentioning

confidence: 99%

“…All EUS examinations were conducted by a single endosonographer except in four, where two or more endosonographers carried out EUS.…”

Section: Resultsmentioning

confidence: 99%

“…EUS staging in the presence of transpapillary staging was carried out in three of the included studies …”

Section: Resultsmentioning

confidence: 99%

“…Among these, EUS has been suggested as the modality of choice in the locoregional staging of ampullary lesions, because the high‐frequency ultrasound transducer probe can be placed in close proximity to the periampullary region. This facilitates real‐time high‐resolution imaging by avoiding interference from soft tissues and bowel gas, and enabling visualization of the unique layers of the duodenal wall …”

Section: Introductionmentioning

confidence: 99%

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Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review

Trikudanathan

Njei

Attam

et al. 2014

Digestive Endoscopy

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Section: Resultsmentioning

confidence: 99%

“…All EUS examinations were conducted by a single endosonographer except in four, where two or more endosonographers carried out EUS.…”

Section: Resultsmentioning

confidence: 99%

“…EUS staging in the presence of transpapillary staging was carried out in three of the included studies …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review

Trikudanathan

Njei

Attam

et al. 2014

Digestive Endoscopy

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“…Although several studies showed the reliability of EUS for T staging of ampullary neoplasms, these were limited by small sample size, heterogeneity of study design (combining both duodenal and ampullary lesions), or limited comparative analysis of intraductal extension with ERCP and surgical pathology. 5,8,10 …”

mentioning

confidence: 99%

Performance characteristics of EUS for locoregional evaluation of ampullary lesions

Ridtitid¹,

Schmidt²,

Al‐Haddad³

et al. 2015

Gastrointestinal Endoscopy

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Background The accuracy of EUS in the locoregional assessment of ampullary lesions is unclear. Objectives To compare EUS with ERCP and surgical pathology for the evaluation of intraductal extension and local staging of ampullary lesions. Design Retrospective cohort study. Setting Tertiary-care referral center. Patients All patients who underwent EUS primarily for the evaluation of an ampullary lesion between 1998 and 2012. Intervention EUS. Main Outcome Measurements Comparison of EUS sensitivity/specificity for intraductal and local extension with ERCP and surgical pathology by using the area under the receiver-operating characteristic (AUROC) curves and outcomes of the subgroup referred for endoscopic papillectomy. Results We identified 119 patients who underwent EUS for an ampullary lesion, of whom 99 (83%) had an adenoma or adenocarcinoma. Compared with ERCP (n = 90), the sensitivity/specificity of EUS for any intraductal extension was 56%/97% (AUROC = 0.77; 95% confidence interval [CI], 0.64-0.89). However, when using surgical pathology as the reference (n = 102), the sensitivity/specificity of EUS (80%/93%; AUROC = 0.87; 95% CI, 0.76-0.97) and ERCP (83%/93%; AUROC = 0.88; 95% CI, 0.77-0.99) were comparable. The overall accuracy of EUS for local staging was 90%. Of 58 patients referred for endoscopic papillectomy, complete resection was achieved in 53 (91%); in those having intraductal extension by EUS or ERCP, complete resection was achieved in 4 of 5 (80%) and 4 of 7 (57%), respectively. Limitation Retrospective design. Conclusions EUS and ERCP perform similarly in evaluating intraductal extension of ampullary adenomas. Additionally, EUS is accurate in T-staging ampullary adenocarcinomas. Future prospective studies should evaluate whether EUS can identify characteristics of ampullary lesions that appropriately direct patients to endoscopic or surgical resection. (Gastrointest Endosc 2015;81:380-8.)

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Diagnostic accuracy of different imaging modalities following computed tomography (CT) scanning for assessing the resectability with curative intent in pancreatic and periampullary cancer

Tamburrino

Riviere

Yaghoobi

et al. 2016

Cochrane Database of Systematic Reviews

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The diagnostic accuracy and strength of agreement between endoscopic ultrasound and histopathology in the staging of ampullary tumors

Abstract: EUS had a moderate strength of agreement with histopathology for both T and N staging, and a high diagnostic accuracy for nodal staging.

Cited by 16 publications

References 25 publications

Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review

Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review

Performance characteristics of EUS for locoregional evaluation of ampullary lesions

Diagnostic accuracy of different imaging modalities following computed tomography (CT) scanning for assessing the resectability with curative intent in pancreatic and periampullary cancer

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