The diagnostic accuracy of dermoscopy for basal cell carcinoma: A systematic review and meta-analysis

Reiter, Ofer; Mimouni, Ilit; Gdalevich, Michael; Marghoob, Ashfaq A.; Levi, Assi; Hodak, Emmilia; Leshem, Yael Anne

doi:10.1016/j.jaad.2018.12.026

Cited by 119 publications

(93 citation statements)

References 28 publications

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“…1 The typical dermoscopic algorithm for the diagnosis of BCC includes the following: erosion or ulceration, maple leaf-like areas, blue-grey globules, ovoid nests, spoke wheel-like areas, brown dots and arborizing vessels. [4][5][6][7] Reflectance confocal microscopy (RCM) is an emerging noninvasive technique for the in vivo imaging of the skin. 3 However, atypical clinical presentation and misleading dermoscopy can sometimes make the diagnosis of BCC particularly challenging.…”

Section: Editormentioning

confidence: 99%

“…2 Most of the light microscopical features are indistinguishable from those of psoriasis, including exocytosis of neutrophils that form superficial accumulations reminiscent of Munro abscesses. 4,5 VX lesions are preponderantly found in the oral cavity, although lesions have also been reported to involve the anogenital region of men or women and, occasionally, extragenital skin. It is a verrucous lesion of papillomatous appearance, with a surface reminiscent of a strawberry or of red caviar and varying in size from 0.2 to 2 cm in diameter.…”

Section: Editormentioning

confidence: 99%

“…3 However, atypical clinical presentation and misleading dermoscopy can sometimes make the diagnosis of BCC particularly challenging. [4][5][6][7] Reflectance confocal microscopy (RCM) is an emerging noninvasive technique for the in vivo imaging of the skin. We present a series of five cases of BCCs where dermoscopy mimicked other types of benign and malignant lesions and the diagnosis was unveiled by RCM.…”

Section: Editormentioning

confidence: 99%

“…By way of exception, it is noted without any associated disorder. 4,5 VX lesions are preponderantly found in the oral cavity, although lesions have also been reported to involve the anogenital region of men or women and, occasionally, extragenital skin. [6][7][8][9] Here, we want to draw the clinicians' attention to a peculiar clinical variant of VX that is highly characteristic, and perhaps even pathognomonic, of the CHILD naevus, and we propose the name 'tympanoxyloid VX', and we found three reports on telephalangeal VX in patients with CHILD syndrome ( Table 1).…”

Section: Editormentioning

confidence: 99%

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Disguised basal cell carcinomas: how to track them down with reflectance confocal microscopy

Paganelli

Garbarino

Ciardo

et al. 2019

Acad Dermatol Venereol

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Section: Editormentioning

confidence: 99%

Section: Editormentioning

confidence: 99%

Section: Editormentioning

confidence: 99%

Section: Editormentioning

confidence: 99%

See 2 more Smart Citations

Disguised basal cell carcinomas: how to track them down with reflectance confocal microscopy

Paganelli

Garbarino

Ciardo

et al. 2019

Acad Dermatol Venereol

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“…It constitutes 65%-80% of non-melanoma skin malignancies (1). It is known that tumor cells that cause BCC originate from pluripotent epithelial cells from the basal layer of the epidermis (2). Approximately 80% of BCCs are located in the head and neck region, because of the density of pilosebaceous glands and the frequency of sun exposure in this region (2).…”

Section: Introductionmentioning

confidence: 99%

The Importance of Preoperative Dermoscopy in Basal Cell Carcinoma Because of a Case of Nodular Cystic BCC

Temiz¹

2019

Erciyes Med J

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Basal cell carcinoma (BCC) is the most widespread malignancy among all malignancies. It constitutes 65%-80% of nonmelanoma skin malignancies. Although there is no universally accepted classification for BCC, there are at least 26 different defined subtypes, which can all be very difficult to recognize. The best-known variants of BCC are nodular, superficial, morpheaform, and infiltrative types. In this report, we describe a patient who was referred for surgery with the diagnosis of cystic BCC by preoperative dermoscopy. Herein, we present a rare form of nodular cystic BCC due to its importance in improving the knowledge of dermoscopy and surgery.

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Association of Multiple Aggregated Yellow-White Globules With Nonpigmented Basal Cell Carcinoma

et al. 2020

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IMPORTANCEBasal cell carcinoma (BCC) is the most common skin cancer. Dermoscopic imaging has improved diagnostic accuracy; however, diagnosis of nonpigmented BCC remains limited to arborizing vessels, ulceration, and shiny white structures.OBJECTIVE To assess multiple aggregated yellow-white (MAY) globules as a diagnostic feature for BCC. DESIGN, SETTING, AND PARTICIPANTSIn this retrospective, single-center, case-control study, nonpigmented skin tumors, determined clinically, were identified from a database of lesions consecutively biopsied during a 7-year period (January 1, 2009, to December 31, 2015. A subset of tumors was prospectively diagnosed, and reflectance confocal microscopy, optical coherence tomography, and histopathologic correlation were performed. Data analysis was conducted from July 1 to September 31, 2019.EXPOSURES Investigators evaluated for the presence or absence of known dermoscopic criteria. MAY globules were defined as aggregated, white-yellow structures visualized in polarized and nonpolarized light. MAIN OUTCOMES AND MEASURESThe primary outcome was the diagnostic accuracy of MAY globules for the diagnosis of BCC. Secondary objectives included the association with BCC location and subtype. Interrater agreement was estimated.RESULTS A total of 656 nonpigmented lesions from 643 patients (mean [SD] age, 63.1 [14.9] years; 381 [58.1%] male) were included. In all, 194 lesions (29.6%) were located on the head and neck. A total of 291 (44.4%) were BCCs. MAY globules were seen in 61 of 291 BCC cases (21.0%) and in 3 of 365 other diagnoses (0.8%) (P < .001). The odds ratio for diagnosis of BCC was 32.0 (96% CI, 9.9-103.2). The presence of MAY globules was associated with a diagnosis of histologic high-risk BCC (odds ratio, 6.5; 95% CI, 3.1-14.3). The structure was never seen in cases of superficial BCCs. CONCLUSIONS AND RELEVANCEThe findings suggest that MAY globules may have utility as a new BCC dermoscopic criterion with a high specificity. MAY globules were negatively associated with superficial BCC and positively associated with deeper-seated, histologic, higher-grade tumor subtypes.

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The diagnostic accuracy of dermoscopy for basal cell carcinoma: A systematic review and meta-analysis

Cited by 119 publications

References 28 publications

Disguised basal cell carcinomas: how to track them down with reflectance confocal microscopy

Disguised basal cell carcinomas: how to track them down with reflectance confocal microscopy

The Importance of Preoperative Dermoscopy in Basal Cell Carcinoma Because of a Case of Nodular Cystic BCC

Association of Multiple Aggregated Yellow-White Globules With Nonpigmented Basal Cell Carcinoma

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