The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in mediastinal tuberculous lymphadenitis

Erer, Onur Fevzi; Erol, Serhat; Anar, Ceyda; Biçmen, Can; Aydoğdu, Zekiye; Aktoğu, Serir

doi:10.3906/sag-1606-110

Cited by 7 publications

(11 citation statements)

References 22 publications

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“…A narrative review among patients with intrathoracic TBLA revealed that the subcarinal and paratracheal lymph nodes were the most frequently sampled nodes during EBUS-TBNA. 17 Similarly, studies carried out in India, France, Turkey and South Africa also revealed that mediastinal lymph nodes (subcarinal and paratracheal) constituted the largest percentage of the sampled nodes during EBUS-TBNA, while hilar nodes had the smallest proportion. 12,[17][18][19] The role of EBUS-TBNA has shown sustained growth over the past 2 decades, from its earlier use in lung cancer staging and evaluation of lesions in the mediastinum to a more extensive utility in the diagnosis of intrathoracic lymphadenopathy.…”

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confidence: 88%

“…In the study by Dar et al 14 , 100 participants had EBUS TBNA for the assessment of intrathoracic lymphadenopathy with a mean age of 48.5±16.65 years. In a report by Erer et al, 17 28 individuals with mediastinal TB Subcarinal lymph nodes (Station No. 7), accounting for approximately 51% of the EBUS-guided sampling, lymphadenopathy had EBUS-TBNA and their mean age was 53.4±15.9 years.…”

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confidence: 98%

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Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Aljohaney

2023

SMJ

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Objectives: To assess the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for presumptive tuberculosis (TB) patients with intrathoracic enlarged lymph nodes in a country with low to moderate TB incidence.Methods: Thirty-one patients with clinical features of TB and intrathoracic lymphadenopathy, who had EBUS-TBNA sampling and final confirmation of intrathoracic TB lymphadenopathy, were retrospectively reviewed over an 8-year period. Routine clinical Original Articleand laboratory evaluations including computerized tomography scans were performed before the EBUS-TBNA. Sociodemographic characteristics, clinical profile, pathological, and microbiological findings were collected. Results:The EBUS-TBNA confirmed TB diagnosis in 26 (83.9%) subjects with a consistent pathological finding or positive culture of Mycobacterium tuberculosis. Pathological analysis had findings consistent with TB in 25 (80.6%) patients. Culture of the EBUS-TBNA sample was positive for Mycobacterium tuberculosis in 12 (38.7%) patients. Other supportive investigations like purified protein derivative (PPD) skin test was positive in 28 (90.3%) participants. Overall, the sensitivity of the EBUS-TBNA alone was 83.9%. No complications were recorded during the procedure. The EBUS-TBNA aspirate culture positivity was significantly related to having a larger size lymph node (p=0.048) only, while PPD positivity was significantly related to baseline and clinical features of the participants. Conclusion:The EBUS-TBNA demonstrated effective utility and safety in the evaluation and diagnosis of intrathoracic TB lymphadenopathy among individuals with compatible symptoms in a country with lowmoderate TB-incidence.

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confidence: 88%

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confidence: 98%

Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Aljohaney

2023

SMJ

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“…If the data relating to the use of TUS are contrasting and do not allow to draw clear conclusions, endobronchial ultrasoundguided transbronchial needle aspiration (EBUS-TBNA) is instead an established minimally invasive method for the assessment of mediastinal/hilar lymphadenopathy in adult with TB. The diagnostic accuracy of the procedure ranges from 68 to 94% among the various studies (21)(22)(23)(24)(25)(26)(27). More limited literature is available on the utility of EBUS-TBNA in children, with a diagnostic accuracy ranging from 36 to 100% (28)(29)(30)(31)(32).…”

Section: Lymphadenopathymentioning

confidence: 99%

Chest Imaging in the Diagnosis and Management of Pulmonary Tuberculosis: The Complementary Role of Thoraci Ultrasound

et al. 2021

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Tuberculosis (TB) is a severe infectious disease that still represents a major cause of mortality and morbidity worldwide. For these reasons, clinicians and radiologists should use all the available diagnostic tools in the assessment of the disease in order to provide precise indications about starting an anti-tubercular treatment and reduce risk of TB transmission and complications especially in developing countries where the disease is still endemic. As TB mycobacteria are mainly transmitted through respiratory droplets, the pulmonary parenchyma is usually the first site of infection. As a result, chest imaging plays a central role in the diagnostic process. Thoracic ultrasound (TUS) is a portable, non-invasive, radiation-free, and cost-contained technology which could be easily available in resource-limited settings. This perspective article focuses on the potential role of TUS in the diagnosis and management of patients with pulmonary TB. Unfortunately, there are still insufficient evidence and too contrasting data to judge TUS as an appropriate diagnostic method for the screening of the disease. Despite this, TUS may have a useful role in identifying pleural and anterior pericardial effusions or in the identification of abscesses of the anterior chest wall and paraspinal collections in low- and middle-income settings. In addition, TUS seems to have a milestone role in guiding minimally invasive interventional procedures, such as placement of chest tubes, drainage of loculated collections, thoracentesis and pericardiocentesis, and percutaneous biopsy of subpleural pulmonary consolidations or pleural plaques.

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“…For good prevention and treatment of postoperative cerebral vasospasm, effective cerebrospinal fluid drainage is essential under the premise of using nimodipine. Sustained lumbar cistern drainage in the early postoperative period can promote the early removal of toxic substances in cerebrospinal fluid, so as to prevent the occurrence of cerebral vasospasm [11][12][13][14][15] .…”

Section: Bmentioning

confidence: 99%

Effect of Lumbar Cistern Drainage Combined with Nimodipine on Cerebral Vasospasm after Intracranial Aneurysm Intervention

Xia¹,

Chen²

2020

pharmaceutical-sciences

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The aim of the present study was to observe and analyze the effect of lumbar cistern drainage combined with nimodipine on cerebral vasospasm after intracranial aneurysm intervention. About 180 patients who underwent intracranial aneurysm intervention in the Second People's Hospital of Liaocheng were enrolled as research subjects. They were randomly divided into the research group and the control group, each containing 90 patients. The control group was subjected to combined therapy of nimodipine with intermittent lumbar puncture to release cerebrospinal fluid; while the research group was subjected to combined therapy of lumbar cistern drainage and nimodipine. The therapeutic effect in both groups of patients was observed and compared. The incidence rate of cerebral vasospasm was significantly lower in the research group when compared to the control group. The cerebrospinal fluid pressure and erythrocyte count on postoperative days 4, 8 and 12 was significantly lower in the research group. Both groups showed significant improvement after treatment, but the improvement in research group was more pronounced. By observing the degree of neurological defects between the 2 groups, the national institutes of health stroke scale score of the research group had significant advantages compared to that of the control group. For patients with intracranial aneurysm interventional therapy, the application of lumbar cistern drainage combined with nimodipine could achieve better results with greater safety.

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The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in mediastinal tuberculous lymphadenitis

Cited by 7 publications

References 22 publications

Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Chest Imaging in the Diagnosis and Management of Pulmonary Tuberculosis: The Complementary Role of Thoraci Ultrasound

Effect of Lumbar Cistern Drainage Combined with Nimodipine on Cerebral Vasospasm after Intracranial Aneurysm Intervention

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