The diagnostic challenges of separating chronic ulcerative stomatitis from oral lichen planus

Qari, Hiba; Villasante, Carmen; Richert, Jordan; Rees, Terry D.; Kessler, Harvey P.

doi:10.1016/j.oooo.2015.07.018

Cited by 30 publications

(54 citation statements)

References 23 publications

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“…7 This method has proved to be a valuable tool in the diagnosis of a number of oral mucosal diseases and remains the gold standard for the differential diagnosis from other lesions such as lupus erythematosus (LE), pemphigus vulgaris, mucous membrane pemphigoid (MMP), and chronic ulcerative stomatitis (CUS). [11][12][13] In general, DIF studies of OLP show positive findings of shaggy fibrin deposition at the basement membrane zone with or without IgM cytoid bodies. 11,12,14,15 In our patient, although the results of the DIF examination were negative, the clinical appearance of the OLP lesions present on the buccal mucosa bilaterally and the histopathological reports of the biopsy specimens taken twice from the most representative area at the same spot were suggestive of OLP without epithelial dysplasia.…”

Section: Discussionmentioning

confidence: 97%

Squamous cell carcinoma arising in plaque-like oral lichen planus: A case report

Prapinjumrune¹,

Chaisuparat²,

Kobkan³

2017

Dent. Med. Probl.

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Section: Discussionmentioning

confidence: 97%

Squamous cell carcinoma arising in plaque-like oral lichen planus: A case report

Prapinjumrune¹,

Chaisuparat²,

Kobkan³

2017

Dent. Med. Probl.

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“…The only study with in‐depth histopathological findings was reported by Qari (Qari et al, ). In this study, 10 mucosal biopsies were reviewed, and 60% of them showed the same features of OLP, 20% of them showed chronic inflammation with lichenoid features, and 20% of them showed non‐specific chronic mucositis.…”

Section: Reviewmentioning

confidence: 99%

“…Chronic ulcerative stomatitis (CUS) is a painful chronic ulcerative process that occurs in the mouth but can occasionally be associated with skin lesions. CUS is defined as an immune‐mediated disorder characterized by oral erosions and ulcers that are usually refractory to conventional treatments (Qari, Villasante, Richert, Rees, & Kessler, ).…”

Section: Introductionmentioning

confidence: 99%

“…To date, 72 cases have been reported (Alshagroud, Neiders, Kramer, & Suresh, ; Beutner et al, ; Chorzelski, Olszewska, Jarząbek‐Chorzelska, & Jablońska, ; Church & Schosser, ; Fourie, van Heerden, McEachen, & van Zyl, ; Islam et al, ; Jaremko et al, ; Kapińska‐Mrowiecka, Czubak‐Macugowska, Michcik, Chomik, & Wlodarkiewicz, ; Ko, Danciu, Fullen, & Chan, ; Lewis, Beutner, Rostami, & Chorzelski, ; Lorenzana, Rees, Glass, & Detweiler, ; Molenda & Kozlowski, ; Parodi & Cardo, ; Qari et al, ; Reddy, Fitzpatrick, Bhattacharyya, Cohen, & Islam, ; Solomon et al, ; Wörle et al, ). However, a literature review has indicated that its prevalence in the general population could be underestimated (Solomon, ).…”

Section: Introductionmentioning

confidence: 99%

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Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria

et al. 2019

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Chronic ulcerative stomatitis (CUS) is an immune‐mediated disorder characterized by oral erosions and ulcers usually refractory to conventional treatments. The disease often involves middle‐aged and older women with painful lesions sometimes resembling those of erosive oral lichen planus (OLP). The most affected sites are the buccal mucosa, the gingiva and the tongue, but the skin is involved in 22.5% of cases. Histopathologic features in CUS are non‐specific and indistinguishable from those of OLP, with the exception of the presence of a mixed infiltrate composed of lymphocytes and plasma cells. Direct immunofluorescence (DIF) analysis reveals the presence of stratified epithelium‐specific antinuclear antibodies (SES‐ANA) in the lower third of the epithelium. The IgG antibodies detected on DIF are directed against the ∆Np63α isoform of p63 expressed in the nuclei of the epithelial basal cells. A distinguishing feature of CUS is the low response to conventional corticosteroid therapy and the good outcome with hydroxychloroquine at the dosage of 200 mg/day or higher dosages. This paper presents a comprehensive review of CUS and is accompanied by a new case report (the 73rd case) and a proposal for updated diagnostic criteria.

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“…Schorzenie ma podłoże autoimmunologiczne i charakteryzuje się opornością na miejscowo i ogólnie podawane preparaty glikokortykosteroidowe [2,27]. Leki przeciwmalaryczne stanowią podstawę leczenia tej jednostki chorobowej [2].…”

Section: Zastosowanie Leków Przeciwmalarycznychunclassified

Application of antimalarial medications in the treatment of skin diseases

Chyl-Surdacka¹,

Przepiórka-Kosińska²,

Gerkowicz³

et al. 2016

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Przegląd Dermatologiczny 2016/4 316 StreSzczenie Leki przeciwmalaryczne są używane w medycynie od ponad 300 lat. Pierwotnie wykorzystywano je do leczenia malarii, obecnie ze względu na właściwości przeciwzapalne, immunomodulujące, antyproliferacyjne i fotoprotekcyjne stosowane są w terapii wielu jednostek chorobowych w dermatologii i reumatologii. Skuteczność preparatów wykazano w leczeniu takich chorób, jak toczeń rumieniowaty układowy, reumatoidalne zapalenie skóry, porfiria skórna późna, liszaj płaski przymieszkowy, wrzodziejące zapalenie jamy ustnej, sarkoidoza, a nawet łysienie plackowate. Chlorochina i hydroksychlorochina są lekami dobrze tolerowanymi, które rzadko powodują poważne objawy niepożądane. Do znanych skutków ubocznych należą: zaburzenia żołądkowo-jelitowe, retinopatia, kardiomiopatia, zaburzenia układu nerwowo-mięśniowego, hiperpigmentacja skóry, zaburzenia hematologiczne. Mimo to leki przeciwmalaryczne nadal są chętnie stosowane również w przebiegu chorób układowych tkanki łącznej w ciąży. Należy jednak zwrócić uwagę na konieczność monitorowania leczenia -okresowych badań narządu wzroku w czasie terapii chlorochiną, szczególnie przy terapii długotrwałej i dużymi dawkami leku. W artykule omówiono mechanizm działania, właściwości farmakokinetyczne, wskazania i działania niepożądane tej grupy leków. AbStrActAntimalarial drugs used in medicine for over 300 years, nowadays, due to their anti-inflammatory, immunomodulatory and antiproliferative photoprotective properties, are used in the therapy of many dermatologic and rheumatologic disorders. The efficacy of these medications is proven in systemic lupus erythematosus, rheumatoid arthritis, porphyria cutanea tarda, lichen planus, ulcerative stomatitis, sarcoidosis, and even alopecia areata. Chloroquine and hydroxychloroquine belong to a group of well-tolerated drugs that occasionally cause adverse effects, which include gastrointestinal disorders, retinopathy, cardiomyopathy, neuromuscular disorders, skin hyperpigmentations, and hematological disorders. Nevertheless, these drugs continue to be frequently applied, including for systemic diseases of connective tissue during pregnancy. However, the treatment must be monitored -periodic ophthalmologic examinations during therapy with chloroquine must be performed, especially during prolonged treatment with high doses of these drugs. The article discusses the mechanism of action, pharmacokinetics, indications and adverse effects of these medications. toczeń rumieniowaty układowy, działania niepożądane, retinopatia, leki przeciwmalaryczne.

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The diagnostic challenges of separating chronic ulcerative stomatitis from oral lichen planus

Cited by 30 publications

References 23 publications

Squamous cell carcinoma arising in plaque-like oral lichen planus: A case report

Squamous cell carcinoma arising in plaque-like oral lichen planus: A case report

Chronic ulcerative stomatitis: A comprehensive review and proposal for diagnostic criteria

Application of antimalarial medications in the treatment of skin diseases

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