The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?

Sciarra, Francesca; Franceschini, Edoardo; Campolo, Federica; Venneri, Mary Anna

doi:10.3390/ijms241310422

Cited by 5 publications

(2 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, a new scenario is linked to the study of the microbial presence of the bacterial microbiome in healthy blood [56]. Identifying potential systemic biomarkers may be beneficial in diagnosing various diseases.…”

Section: Roles Of the Gut Microbiota Referencesmentioning

confidence: 99%

Gut–Kidney–Heart: A Novel Trilogy

Caldarelli,

Franza,

Rio

et al. 2023

Biomedicines

View full text Add to dashboard Cite

The microbiota represents a key factor in determining health and disease. Its role in inflammation and immunological disorders is well known, but it is also involved in several complex conditions, ranging from neurological to psychiatric, from gastrointestinal to cardiovascular diseases. It has recently been hypothesized that the gut microbiota may act as an intermediary in the close interaction between kidneys and the cardiovascular system, leading to the conceptualization of the “gut–kidney–heart” axis. In this narrative review, we will discuss the impact of the gut microbiota on each system while also reviewing the available data regarding the axis itself. We will also describe the role of gut metabolites in this complex interplay, as well as potential therapeutical perspectives.

show abstract

Section: Roles Of the Gut Microbiota Referencesmentioning

confidence: 99%

Gut–Kidney–Heart: A Novel Trilogy

Caldarelli,

Franza,

Rio

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…The precise origin of blood microbiota has yet to be definitively determined. The leaky gut barrier and translocation of microbiota in oral and skin may be the sources [ 117 ]. Moreover, liver clearance and the immune system have important effects on the blood microbiome, emphasizing the necessity of incorporating these factors in future investigations [ 118 ].…”

Section: Roles Of the Microbiome In Ckdmentioning

confidence: 99%

The gut microbiome tango in the progression of chronic kidney disease and potential therapeutic strategies

Tang,

Yu,

Pan

2023

J Transl Med

View full text Add to dashboard Cite

Chronic kidney disease (CKD) affects more than 10% population worldwide and becomes a huge burden to the world. Recent studies have revealed multifold interactions between CKD and gut microbiome and their pathophysiological implications. The gut microbiome disturbed by CKD results in the imbalanced composition and quantity of gut microbiota and subsequent changes in its metabolites and functions. Studies have shown that both the dysbiotic gut microbiota and its metabolites have negative impacts on the immune system and aggravate diseases in different ways. Herein, we give an overview of the currently known mechanisms of CKD progression and the alterations of the immune system. Particularly, we summarize the effects of uremic toxins on the immune system and review the roles of gut microbiota in promoting the development of different kidney diseases. Finally, we discuss the current sequencing technologies and novel therapies targeting the gut microbiome.

show abstract

Design, Development, and Validation of a Nanobiosensor to Detect Circulating Microbiome for Cardiovascular Disease Risk Assessment

Nazeer

Dewangan

Gurjar

et al. 2023

Preprint

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is a serious worldwide health concern that necessitates the development of novel diagnostic techniques for early identification and personalized healthcare management. Even before the insights provided by gut microbiota, current research has demonstrated the importance of circulating microbiome (CMB) in the evolution of cardiometabolic illness risk and progression. We developed a nanobiosensor that uses specific labeled capture probes with perovskite quantum dots (PQDs) to detect the targeted 16S rRNA sequences in the peripheral milieu. With ideal applicability, specificity, and sensitivity, this sensor delivers unique insights into the presence and characterization of circulating microbiota signatures. Developing a nanophotonic microbiome detection method in body fluids may pave the way for creating a distinctive tool for CVD risk prediction for population-based screening programs in low and middle-income countries.

show abstract

The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?

Cited by 5 publications

References 102 publications

Gut–Kidney–Heart: A Novel Trilogy

Gut–Kidney–Heart: A Novel Trilogy

The gut microbiome tango in the progression of chronic kidney disease and potential therapeutic strategies

Design, Development, and Validation of a Nanobiosensor to Detect Circulating Microbiome for Cardiovascular Disease Risk Assessment

Contact Info

Product

Resources

About