The diagnostic significance of the minimal erythema dose

Stern, William K.

doi:10.1001/archderm.105.3.387

Cited by 6 publications

(3 citation statements)

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“…However, this is often referred to in terms of minimal erythemal dose (MED), with little or no reference to the actual dose received. Stern and Urbach 8 stated that ‘it is not always clear whether “minimal” refers to the shade of erythema produced or to the least amount in energy in one of a series of increasing doses that produces erythema’. Stern and Urbach 8 subsequently commented that variables such as time to generate MED or the spectral output of the light source used were rarely mentioned.…”

Section: Ultraviolet Light Methodologymentioning

confidence: 99%

“…Stern and Urbach 8 stated that ‘it is not always clear whether “minimal” refers to the shade of erythema produced or to the least amount in energy in one of a series of increasing doses that produces erythema’. Stern and Urbach 8 subsequently commented that variables such as time to generate MED or the spectral output of the light source used were rarely mentioned. Recent publications have begun to correct these oversights, thus allowing easier comparison between different investigations.…”

Section: Ultraviolet Light Methodologymentioning

confidence: 99%

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Ultraviolet light induced injury: Immunological and inflammatory effects

2001

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Summary This article reviews many of the complex events that occur after cutaneous ultraviolet (UV) exposure. The inflammatory changes of acute exposure of the skin include erythema (sunburn), the production of inflammatory mediators, alteration of vascular responses and an inflammatory cell infiltrate. Damage to proteins and DNA accumulates within skin cells and characteristic morphological changes occur in keratinocytes and other skin cells. When a cell becomes damaged irreparably by UV exposure, cell death follows via apoptotic mechanisms. Alterations in cutaneous and systemic immunity occur as a result of the UV-induced inflammation and damage, including changes in the production of cytokines by keratinocytes and other skin-associated cells, alteration of adhesion molecule expression and the loss of APC function within the skin. These changes lead to the generation of suppressor T cells, the induction of antigen-specific immunosuppression and a lowering of cell-mediated immunity. These events impair the immune system's capacity to reject highly antigenic skin cancers. This review gives an overview of the acute inflammatory and immunological events associated with cutaneous UV exposure, which are important to consider before dealing with the complex interactions that occur with chronic UV exposure, leading to photocarcinogenesis.

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Section: Ultraviolet Light Methodologymentioning

confidence: 99%

Section: Ultraviolet Light Methodologymentioning

confidence: 99%

Ultraviolet light induced injury: Immunological and inflammatory effects

2001

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“…Twenty‐four hours after the application, UVB irradiation (1·5 minimal erythema dose, MED) was carried out (upper back). The MED was determined individually 24 h before irradiation by standard methods 8 . Erythema suppression was measured at 8, 24 and 48 h after UVB irradiation by visual scoring (upper back).…”

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confidence: 99%