The diagnostic value of 18F-FDG PET and MRI in paediatric histiocytosis

Mueller, Wolfgang P.; Melzer, Henriette Ingrid; Schmid, Irene; Coppenrath, Eva; Bartenstein, Peter; Pfluger, Thomas

doi:10.1007/s00259-012-2278-6

Cited by 63 publications

(42 citation statements)

References 24 publications

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“…As contrast enhancement on CEMRI has been shown to correlate with disease activity or perilesional inflammation, MRI is equally used to evaluate treatment response [27]. On FDG PET CT, LCH lesions are FDG avid (Fig.…”

Section: Primary Intraosseous Tumorsmentioning

confidence: 99%

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Non-odontogenic tumors of the facial bones in children and adolescents: role of multiparametric imaging

et al. 2017

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Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of these lesions. Although rare, pediatric tumors arising in the facial bones comprise a wide spectrum of benign and malignant lesions of osteogenic, fibrogenic, hematopoietic, neurogenic, or epithelial origin. The more common lesions include Langerhans cell histiocytosis and osteoma, while rare lesions include inflammatory myofibroblastic and desmoid tumors; juvenile ossifying fibroma; primary intraosseous lymphoma; Ewing sarcoma; and metastases to the facial bones from neuroblastoma, Ewing sarcoma, or retinoblastoma. This article provides a comprehensive approach for the evaluation of children with non-odontogenic tumors of the facial skeleton. Typical findings are discussed with emphasis on the added value of multimodality multiparametric imaging with computed tomography (CT), magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), positron emission tomography CT (PET CT), and PET MRI. Key imaging findings and characteristic histologic features of benign and malignant lesions are reviewed and the respective role of each modality for pretherapeutic assessment and post-treatment follow-up. Pitfalls of image interpretation are addressed and how to avoid them.

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Section: Primary Intraosseous Tumorsmentioning

confidence: 99%

“…3). However, due to the small size of some lesions, the overall sensitivity of FDG PET is limited (67%) [27]. The relatively high specificity of FDG PET for LCH (76% as opposed to only 47% with MRI) provides important information regarding disease response.…”

Section: Primary Intraosseous Tumorsmentioning

confidence: 99%

Non-odontogenic tumors of the facial bones in children and adolescents: role of multiparametric imaging

et al. 2017

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“…MRI, in particular, more accurately diagnosed brain involvement. Combined PET-MRI analysis improved falsenegative and false-positive rates in primary staging, whereas no clear advantage over PET alone was seen for disease follow-up [51]. Considering that fully integrated PET-MRI hybrid systems may soon become widespread, simultaneous PET-MRI acquisition has the potential to become the first choice for initial evaluation of patients with LCH allowing to reduce examination time and radiation exposure while maintaining a high diagnostic accuracy.…”

Section: Systemic Imaging Findingsmentioning

confidence: 93%

Management of diabetes insipidus and adipsia in the child

Iorgi¹,

Morana²,

Napoli³

et al. 2015

Best Practice & Research Clinical Endocrinology & Metab

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“…Note the high conspicuity of the lesion on diffusion-weighted imaging (DWI; small arrow) compared to SSFSE single-shot fast spin echo imaging only for neuroradiologic applications but also in children with sarcoma, lymphoma, small cell cancers, and other cancers which also benefit from the physiologic characterization and metabolic information from PET [68,[70][71][72][73].…”

Section: Pediatric Neoplasmsmentioning

confidence: 99%

PET/MRI: Applications in Clinical Imaging

et al. 2013

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PET/MRI is a new hybrid modality which is increasingly being used in clinical settings, although both clinical evaluation and technical optimization are still an ongoing process. Initial experience with this new imaging device proves promising for oncologic applications. Other clinical indications in the field of cardiac imaging and neuroimaging are also being explored. This article aims to review the current status of PET/MRI and its value in oncologic applications, and summarizes our own preliminary experience in this field.

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The diagnostic value of 18F-FDG PET and MRI in paediatric histiocytosis

Cited by 63 publications

References 24 publications

Non-odontogenic tumors of the facial bones in children and adolescents: role of multiparametric imaging

Non-odontogenic tumors of the facial bones in children and adolescents: role of multiparametric imaging

Management of diabetes insipidus and adipsia in the child

PET/MRI: Applications in Clinical Imaging

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