The diagnostic value of 24‐hour ambulatory intraesophageal pH‐impedance in patients with laryngopharyngeal reflux symptoms comparable with typical symptoms

Sakin, Yusuf Serdar; Vardar, Rukiye; Sezgin, Baha; Çetin, Zeynep; Alev, Yasemin; Yildirim, Esra; Kirazlı, Tayfun; Bor, Serhat

doi:10.1177/2050640616675040

Cited by 23 publications

(24 citation statements)

References 36 publications

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“…Previous studies reported that patients with pathologic LPR symptom scores had lower proximal BI levels and lower proximal-to-distal ratios. 15 However, in the current study, the BI levels of the proximal z3 area in the LPR group were lower and had higher proximal-to-distal ratios than the control group ratios, but the results were not statistically significant ( P > .05). In addition, the BI values of proximal z3 areas and proximal-to-distal ratios were very similar between the control and SNR groups (BI at proximal z3, 2563.5 ± 780 vs 2570.4 ± 781; proximal-to-distal ratio, 1.07 vs 1.07, respectively).…”

Section: Discussioncontrasting

confidence: 77%

Changes in Pharyngeal Baseline Impedance in Patients With Laryngopharyngeal Reflux

Doo

Kim

Park

et al. 2020

Otolaryngol.--head neck surg.

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Objective Few studies have investigated pharyngeal intraluminal baseline impedance (BI) levels in patients with laryngopharyngeal reflux (LPR). The aim of this study was to compare intraluminal BI levels between patients with LPR and healthy controls. Study Design Retrospective case series. Setting Tertiary care medical center. Subjects and Methods We conducted a retrospective analysis of 24-hour multichannel intraluminal impedance (MII)–pH monitoring results from patients with suspected LPR complaining of reflux symptoms. Patients with suspected LPR were divided into 2 groups according to the 24-hour MII-pH monitoring (LPR group: patients with symptoms with reflux events ≥1, symptom but no reflux [SNR] group: patients with symptoms but no reflux event). Healthy controls were recruited and also underwent 24-hour MII-pH monitoring. We compared the esophageal and pharyngeal BI levels and ratios between 3 groups. Results Pharyngeal BI levels in the LPR group were significantly higher than in the healthy controls. In addition, the pharyngeal BI levels in the SNR group were significantly higher than in the healthy controls. All ratios of pharyngeal to distal esophageal BI levels in the LPR and SNR group were significantly higher than in the healthy controls. However, there were no significant differences in esophageal BI levels and ratios between the 3 groups. Conclusion We found that the pharyngeal BI levels were higher in patients with LPR than in healthy controls. In addition, the pharyngeal BI levels measured by 24-hour MII-pH monitoring in patients with LPR symptoms, but without a reflux episode, were higher than in the healthy controls.

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Section: Discussioncontrasting

confidence: 77%

Changes in Pharyngeal Baseline Impedance in Patients With Laryngopharyngeal Reflux

Doo

Kim

Park

et al. 2020

Otolaryngol.--head neck surg.

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“…2 Studies have found lower impedance values in patients with gastroesophageal reflux disease (GERD) compared with healthy control subjects. 3 In our recent study, 4 we found that compared with GERD patients without extraesophageal symptoms, patients with extraesophageal symptoms (related to GERD) had similar distal esophageal impedance but significantly lower proximal esophageal impedance. This may be caused by exposure of the proximal esophagus to the refluxate.…”

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confidence: 76%

Bile Acid Deficiency and Constipation

Palmer¹

2018

Clinical Gastroenterology and Hepatology

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“…A former study published by Sakin retrospectively included suspected LPR patients and nonerosive reflux disease patients. Proximal baseline impedance and proximal‐to‐distal ratios were found to be lower among patients with pathologic laryngopharyngeal Reflux Finding Score . However, patients with suspected esophageal motility disorders and esophagitis were all excluded and therapy outcome was not discussed in the study.…”

Section: Discussionmentioning

confidence: 99%

A study of proximal esophageal baseline impedance in identifying and predicting laryngopharyngeal reflux

Chen

Liang

Zhang

et al. 2020

J of Gastro and Hepatol

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Background and Aim: Laryngopharyngeal reflux (LPR) is caused by the reflux of gastric contents beyond the esophagus into the larynx and pharynx. However, upper esophageal sphincter (UES) motility and proximal esophagus reflux parameters are poorly studied. This study aims to explore the characteristics of UES motility and reflux parameter among LPR patients. Methods: Patients with laryngopharyngeal symptoms only (L), patients with laryngopharyngeal symptoms and typical esophageal symptoms (L + E), patients with typical esophageal symptoms only (E), and healthy controls (H) were retrospectively included. Physiological profiles were studied and compared among groups using both high-resolution manometry and pH-impedance monitoring, including UES basal pressure, residual pressure, relaxation duration time, recovery time, the time to nadir pressure, UES length, proximal contractile integral, and proximal mean nocturnal baseline impedance (MNBI). Patients' symptom outcomes were also analyzed. Results: A total of 242 patients were included. Proximal MNBI was significantly lower in patients with both laryngopharyngeal and esophageal symptoms (17 cm above low esophageal sphincter [LES]: L vs L + E vs E vs H = 3689.7 vs 2500.0 vs 3073.0 vs 3996.0; 15 cm above LES: L vs L + E vs E vs H = 3155.9 vs 2553.4 vs 3198.9 vs 2985.2; P < 0.001). Patients responded to proton pump inhibitor treatment also had lower proximal MNBI than those who did not (17 cm above LES: 1834.0 vs 3500.0; 15 cm above LES: 1946.5 vs 3432.6; P < 0.001). Conclusion: Decreased proximal MNBI can not only identify LPR patients but also predict patients' symptom outcomes.

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The diagnostic value of 24‐hour ambulatory intraesophageal pH‐impedance in patients with laryngopharyngeal reflux symptoms comparable with typical symptoms

Cited by 23 publications

References 36 publications

Changes in Pharyngeal Baseline Impedance in Patients With Laryngopharyngeal Reflux

Changes in Pharyngeal Baseline Impedance in Patients With Laryngopharyngeal Reflux

Bile Acid Deficiency and Constipation

A study of proximal esophageal baseline impedance in identifying and predicting laryngopharyngeal reflux

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