The Diagnostic Value of a New Fecal Marker, Matrix Metalloprotease-9, in Different Types of Inflammatory Bowel Diseases

Farkas, Klaudia; Saródi, Zoltán; Bálint, Anita; Földesi, Imre; Tiszlavicz, László; Szűcs, Mónika; Nyári, Tibor; Tajti, János; Nagy, Ferenc; Szepes, Zoltán; Bor, Renáta; Annaházi, Anita; Róka, R; Molnár, Tamás

doi:10.1093/ecco-jcc/jjv005

Cited by 46 publications

(41 citation statements)

References 24 publications

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“…The activity of some MMPs (MMP-1, 2, 3 and 9) is also augmented in colon of IBD patients and is correlated with MPO level and tissue damage [106]. Strong associations are shown between faecal MMP-9 and clinical, endoscopic, and histologic activities of UC, but no correlation are found between this biomarker and activity indices of CD [107]. …”

Section: Role Of Neutrophil-derived Moleculesmentioning

confidence: 99%

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

Wéra

Lancellotti

Oury

2016

JCM

239

189

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Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration. These two diseases are considered distinct entities, and there is some evidence that neutrophil behaviour, above all other aspects of immunity, clearly separate them. Neutrophils are the first immune cells recruited to the site of inflammation, and their action is crucial to limit invasion by microorganisms. Furthermore, they play an essential role in proper resolution of inflammation. When these processes are not tightly regulated, they can trigger positive feedback amplification loops that promote neutrophil activation, leading to significant tissue damage and evolution toward chronic disease. Defective chemotaxis, as observed in Crohn’s disease, can also contribute to the disease through impaired microbe elimination. In addition, through NET production, neutrophils may be involved in thrombo-embolic events frequently observed in IBD patients. While the role of neutrophils has been studied in different animal models of IBD for many years, their contribution to the pathogenesis of IBD remains poorly understood, and no molecules targeting neutrophils are used and validated for the treatment of these pathologies. Therefore, it is crucial to improve our understanding of their mode of action in these particular conditions in order to provide new therapeutic avenues for IBD.

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Section: Role Of Neutrophil-derived Moleculesmentioning

confidence: 99%

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

Wéra

Lancellotti

Oury

2016

JCM

239

189

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“…Despite MMP-9 being elevated in both CD and UC, the performance of MMP-9 as a disease marker appears to be better in UC and pouchitis [65]. Kolho et al [66] compared the performance of MMP-9 to that of calprotectin in distinguishing IBD from non-IBD subjects.…”

Section: Matrix Metalloproteinasementioning

confidence: 99%

Novel Biomarkers and the Future Potential of Biomarkers in Inflammatory Bowel Disease

Duvoisin

Lopez

Day

et al. 2017

Mediators of Inflammation

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There is increasing importance placed upon noninvasive assessment of gut inflammation. These tools are likely to be the key in differentiating intestinal inflammatory disease from functional disorders and in monitoring the response to intervention in individuals with known inflammatory conditions. Although various noninvasive markers are currently available, they have limitations and do not provide ideal utility. This review focuses on emerging markers of gut inflammation, highlighting the potential of specific markers.

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“…Potential biomarkers are constantly being discovered [48]- [50]. Recent studies on neopterin demonstrated its ability to identify patients with IBD with active mucosal lesions and could potentially be used to assess the severity their mucosal damage [51].…”

Section: Other Markersmentioning

confidence: 99%