The diagnostic value of adenosine deaminase activity in sputum in pulmonary tuberculosis

Dilmaç, A; Ucoluk, Gulnur Onde; Uğurman, Feza; Gözü, Ayşe; Akkalyoncu, Behiye; Eryılmaz, Türkan; Samurkaşoğlu, Belgin

doi:10.1053/rmed.2002.1321

Cited by 19 publications

(11 citation statements)

References 8 publications

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“…Dilmac¸et al [16] found that sputum ADA activities in tuberculous group were significantly higher than the other two groups (P < 0.01 for lung cancer group, P < 0.05 for COPD) and this coincide with our findings. Also there was a significant increase in serum ADA activities in tuberculous patients than bronchogenic carcinoma and chronic obstructive pulmonary disease patients (P < 0.05) and this also coincide with the present study.…”

Section: Discussionsupporting

confidence: 92%

“…In accordance with our findings Dimakou et al [14] tried to evaluate the diagnostic value of sputum ADA, ADA1 and ADA2 activity in pulmonary tuberculosis and found that sputum total ADA activity was significantly higher in TB than in lung cancer patients (median 18 U/L [range 3-70] vs. 6 U/L [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]; P < 0.001) respectively and sputum ADA2 activity was significantly higher in TB compared to lung cancer patients (9 U/L [0-65] vs. 5 U/L [0-12]; P = 0.001) respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly Dilmac¸et al [16] tried to assess the diagnostic value of adenosine deaminase activity in sputum of patients with pulmonary tuberculosis, their aim was to determine and compare sputum ADA activity in pulmonary tuberculosis, lung cancer and chronic obstructive pulmonary disease (COPD) patients in order to assess its diagnostic value.…”

Section: Discussionmentioning

confidence: 99%

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The diagnostic value of adenosine deaminase activity in pulmonary tuberculosis: Comparison between sputum and serum

Atta

Kassem

Elhadidi

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: Tuberculosis is a chronic specific bacterial infection caused by bacteria of the Mycobacterium tuberculosis. It remains one of the deadliest diseases in the world. It is the second leading infectious cause of death after HIV infection. Adenosine deaminase (ADA) activity is increased in various conditions such as liver disease, tuberculosis, typhoid, infective mononucleosis and certain malignancies, especially those of haematopoietic origin.Objective: The aim of the work was to assess the diagnostic value of ADA in pulmonary tuberculosis by comparing levels in sputum and serum.Subjects and methods: The present study included 15 patients with active pulmonary tuberculosis, 15 patients with pneumonia and 15 patients diagnosed as lung cancer. All patients were subjected to: Full history taking, complete clinical examination, laboratory investigations, and plain X-ray chest. Measurement of sputum and serum level of ADA of all patients using specific immunoassay method.Results: There was a significant increase in sputum ADA in tuberculous group in relation to the other groups (mean sputum ADA was 159.76 ± 16.95, 84.34 ± 6.87 and 67.30 ± 7.47 U/L, respectively). The mean serum ADA was 31.99 ± 8.85, 24.15 ± 4.22and 14.84 ± 2.43 U/L in tuberculous group, pneumonia group and bronchogenic carcinoma group, respectively. There was a statistically significant increase in serum ADA in the tuberculous group in relation to the other groups (F 10.65, P 0.001 * ). There was a statistically significant positive correlation between sputum and serum ADA (r = 0.75, P = 0.0001).Conclusion: The results support the feasibility of using sputum ADA for diagnosis of pulmonary tuberculosis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The diagnostic value of adenosine deaminase activity in pulmonary tuberculosis: Comparison between sputum and serum

Atta

Kassem

Elhadidi

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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“…The developed score did not include other clinical tools that have been employed for the diagnosis of SNPT such as fibrobroncoscopy [9][10][11][12][13], the use of induced sputum [14][15][16][17][18][19][20], concentration techniques [21][22][23][24], auramine-rhodamine enhanced AFB detection [25,26], or Adenosine deaminase activity in sputum or bronchoalveolar lavage [27][28][29][30] or fine needle aspiration [31,32]. Also, the use of liquid media culture was not evaluated.…”

Section: Discussionmentioning

confidence: 99%

Development of a clinical scoring system for the diagnosis of smear-negative pulmonary tuberculosis

et al. 2008

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This study developed a clinical score based on clinical and radiographic data for the diagnosis of smear-negative pulmonary tuberculosis (SNPT). SNPT was defined as a positive culture in Ogawa in a patient with two negative sputum smears. Data from patients admitted to the emergency ward with respiratory symptoms and negative acidfast bacilli (AFB) smears was analyzed by means of logistic regression to develop the predictive score.Two hundred and sixty two patients were included. Twenty patients had SNPT. The variables included in the final model were hemoptysis, weight loss, age > 45 years old, productive cough, upper-lobe infiltrate, and miliary infiltrate. With those, a score was constructed. The score values ranged from -2 to 6. The area under the curve for the ROC curve was 0.83 (95% CI 0.74-0.90). A score of value 0 or less was associated with a sensitivity of 93% and a score of more than 4 points was associated with a specificity of 92% for SNPT. Fifty-two point twenty-nine percent of patients had scores of less than one or more than four, what provided strong evidence against and in favor, respectively, for the diagnosis of SNPT. The score developed is a cheap and useful clinical tool for the diagnosis of SNPT and can be used to help therapeutic decisions in patients with suspicion of having SNPT.

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“…Previous studies have shown an inconclusive result for serum ADA activity in lung cancer (15)(16)(17)(18). In addition, serum tumour markers are not useful in lung cancer diagnosis (1).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Nikkhoo¹,

Sigari²,

Ghaderi³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: This study aimed to determine adenosine deaminase (ADA) activity as a possible screening tool in lung cancer patients. Methods: Blood samples were collected from 30 subjects with positive pathological tests and 62 patients with negative pathological tests as a control group. The enzymatic activity of total ADA and its isoenzymes was determined. Results: tADA and ADA2 isoenzyme activity was significantly higher in cancerous patients compared to benign controls in serum and BAL fluid. Using a cut-off level of respectively 35.22 U/L and 31.80 U/L for BAL total ADA and ADA2, sensitivity and specificity were 100% and 81% for total ADA and 95% and 98% for ADA2. Conclusions: Adenosine deaminase may play important roles in the pathophysiology of lung cancer and because of its

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The diagnostic value of adenosine deaminase activity in sputum in pulmonary tuberculosis

Cited by 19 publications

References 8 publications

The diagnostic value of adenosine deaminase activity in pulmonary tuberculosis: Comparison between sputum and serum

The diagnostic value of adenosine deaminase activity in pulmonary tuberculosis: Comparison between sputum and serum

Development of a clinical scoring system for the diagnosis of smear-negative pulmonary tuberculosis

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

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