The Diagnostic Value of Anti-Parietal Cell and Intrinsic Factor Antibodies, Pepsinogens, and Gastrin-17 in Corpus-Restricted Atrophic Gastritis

Abstract

We aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA (Inova, Biohit). Our study compared 29 CRAG cases against 58 age- and sex-matched controls with mild or no atrophy. Anti-PCA and anti-IFA positive cutoff values were ≥25 units for both. PGI/II value <3 was considered characteristic for atrophy; positive cutoff values for G-17 and anti-H. pylori IgG were >5 pg/L and >30 EIU. Anti-PCA was positive in 65.5% For CRAG cases and 13.8% of the controls (p < 0.0001), anti-IFA was positive in 13.8% and 0% (p = 0.01), respectively. Decreased pepsinogen levels were present in 79.3% of CRAG cases and 10.3% of the controls (p < 0.0001). PGI/II ratio was the best single biomarker, with sensitivity = 79%, specificity = 90%, and AUC 0.90. The combined use of PGI/II and anti-PCA resulted in AUC 0.93 for detecting CRAG. Our study suggests that the best combination of non-invasive biomarkers for detecting CRAG is PGI/II with anti-PCA. The addition of G-17 and anti-IFA is of little utility in clinical application.

Update in Molecular Aspects and Diagnosis of Autoimmune Gastritis

“…A preceding study has established the diagnostic significance of gastrin levels surpassing 355 pg/mL in the identification of autoimmune gastritis [47]. Nevertheless, an alternative study proposes that the most effective combination of noninvasive biomarkers for detecting corpus-restricted atrophic gastritis consists of PGI/II with anti-parietal cell antibodies, whereas the inclusion of gastrin levels offers minimal utility in clinical applications [54].…”

Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics

“…Эти изменения обуславливают мальабсорбцию железа и витамина B 12 [8,9]. Обнаружение аутоантител против H + -, K + -АТФазы и внутреннего фактора, снижение сывороточного пепсиногена I и соотношения пепсиногена I к пепсиногену II, повышение гастрина-17 важны для диагностики АИГ [4,[9][10][11][12]. АИГ часто сочетается с таким аутоиммунным заболеванием, как аутоиммунный тиреоидит, реже с сахарным диабетом 1-го типа, болезнью Аддисона, витилиго и хронической крапивницей [9,11].…”