The Diagnostic Value of N-Acetyl-β-D-Glucosaminidase and Microalbumin Concentrations in Rheumatoid Arthritis

Spasovski, Dejan; Gruev, Todor; Marina, Nada; Calovski, Jordan; Percinkova, Snežana; Osmani, Baskim; Rajčevska, Ljubinka; Cakalaroski, K; Sotirova, Tatjana; Balkanov, Svetlana Krstevska; Slaninka-Micevska, Maja

doi:10.2478/v10011-007-0038-0

Cited by 9 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This probably is due to the regeneration processes which is proved on the level of the tubular epithelium, also noticed by other authors (39,40). However, that is not the case with the membrane AAP, γ glutamyl transferase, γ-GT and AF, which after the treatment stay on high significant levels in terms of decreased activity.…”

Section: Discussionmentioning

confidence: 63%

Symmetric dimethyl arginine and N-acetyl- β-D-glucosaminidase lysosimyria of proximal renal tubules as a target for nephrotoxicity in patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs.

Spasovski¹,

Latifi²,

Marina³

et al. 2013

J Nephropathol

Self Cite

View full text Add to dashboard Cite

Background: The aim of this study was to determine the effect of initial therapy with some disease modifying antirheumatic drugs (DMARDs) (Methotrexate and Ketoprofen) on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA). Objectives: To determine whether there is a change in clinical and laboratory indicators of renal function in course of the follow up of treatment and whether that change correlates with the dynamics of the quantity of enzymes excreted in urine and reactants of the acute phase. Materials and Methods: Using colorimetric method for determination of NAG, samples of 70 participants were examined (35 RA patients treated with Ketoprofen only, 35 RA patients treated with combined use of Methotrexate and Ketoprofen). The follow up was 5 time-intervals in the course of 24 weeks. Results: There was moderate correlation between NAG and microalbuminuria (r=0,34) in the group of patients treated with Ketoprofen only, while statistically significant correlation (r=0,21) was seen in group of patients with combined use of Methotrexate and Ketoprofen. NAG enzymuria in size, number of patients registered, and time of appearance were greater and appears earlier in the group with the combined use of Methotrexate and Ketoprofen compared with the mono-therapy with Ketoprofen. Mean urinary NAG induction was increasing with the concomitant use of Methotrexate and Ketoprofen. Conclusions: Methotrexate is more potent NAG inductor than Ketoprofen and provokes greater tubular enzymuria than Ketoprofen. www.nephropathol.com DOI:10.5812/nephropathol.8989 J Nephropathology. 2013; 2(1): 36-52 Original Article Journal of NephropathologyImplication for health policy/practice/research/medical education: Determination of the urinary N-acetyl-β-D-glucosaminidase together with the urinary creatinine excretion could serve as a more sensitive test for renal lesions in patients suffering from rheumatoid arthritis, as an additional diagnostic tool, and the information for the status of the disease.

show abstract

Section: Discussionmentioning

confidence: 63%

Symmetric dimethyl arginine and N-acetyl- β-D-glucosaminidase lysosimyria of proximal renal tubules as a target for nephrotoxicity in patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs.

Spasovski¹,

Latifi²,

Marina³

et al. 2013

J Nephropathol

Self Cite

View full text Add to dashboard Cite

show abstract

“…There are no literature data about the toxic effect of these drugs on proximal tubular dysfunction. In untreated RA tubular and much less gromerular function are primarily affected [21]. Glomerular integrity is basically intact in the examined groups of RA patients with the use of Paracetamol and Ketoprofen.…”

Section: Discussionmentioning

confidence: 81%

Some Aspects of Nephrotoxicity of Paracetamol and Ketoprofen in Patients with Rheumathoid Arthritis

Spasovski¹,

Genadieva-Stavric²,

Sotirova³

2016

Macedonian Medical Review

Self Cite

View full text Add to dashboard Cite

Introduction. To determine the effect of initial therapy with Paracetamol and Ketoprofen on glomerular and tubular integrity in rheumatoid arthritis (RA), to quantify nephrotoxicity of these two drugs by measurement of enzymuria, which correlates with the damage of tubular epithelium. Microalbuminuria is used as a marker for glomerular damage, and urine excretion of N-Acetylb-D-glucosaminidase (NAG) as an indicator of proximal tubular damage. Methods. Using colorimetric method for determination of NAG, and immunoturbidimetric method for microalbuminuria, samples of 70 participants were examined (35 RA patients treated with Paracetamol only, 35 RA patients treated with Ketoprofen). The follow-up was in 5 time-intervals in the course of 24 weeks.Results. There was a moderate correlation between NAG and microalbuminuria (r=0.16) in the group of patients treated with Paracetamol only, and a moderate correlation (r=0.28) in the group of patients treated with Ketoprofen. NAG enzymuria in size, by number of patients Registered, and time of appearance, was greater and appeared earlier in the Ketoprofen group compared to the Paracetamol group. Conclusions. Ketoprofen is more potent NAG inductor and provokes greater tubular enzymuria than Paracetamol. Results from our study confirm safety in use of Paracetamol and Ketoprofen in everyday clinical practice.

show abstract

“…In untreated RA primarily is affected tubular and much less glomerular function (21). Glomerular integrity is basically intact in the examined groups of RA patients with the use of Paracetamol and Ketoprofen.…”

Section: Discussionmentioning

confidence: 85%

Potency of Enzymes from Renal Tubules as Biotracers in Rheumatoid Arthritis Patients Treat With Most Used Antirheumatic Drugs

Spasovski¹

2017

Arch Clin Biomed Res

Self Cite

View full text Add to dashboard Cite

Aim:To estimate the effect of initial therapy with Paracetamol and Ketoprofen on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA), to quantify the toxicity of these drugs through measurements of the enzyme excretion that correlates with the damage degree on the tubular epithelium. Microalbuminuria is used as a marker for glomerular damage, and the urinary excretion of N-Acetyl--D-glucozaminidase (NAG) as an indicator of proximal tubular damage. To determine if there is a change in the clinical indicators of renal function (serum urea and creatinine, urine urea and creatinine, glomerular filtration rate -GFR) in the course of disease and if that change correlates with the dynamics of the quantity of excreted enzymes in urine, reactants of the acute pfase and index of disease activity (DAS28).Methods: Using the colorimetric method for the determination of NAG, as well as immunoturbidimetric immunoturbidimetric assay for detection of microalbuminuria, we examined samples of 70 participants (35 RA pts treated only with Paracetamol, 35 RA pts treated with Ketoprofen), followed up in five time intervals in the course of 24 weeks. Rheumatoid factor (RF) is determined by the agglutination test (Lateks RF test) in the same participants.Results: there is a weak correlation between NAG and microalbuminuria (r=0.16) in the group of patients treated with Paracetamol, while in the group treated with Ketoprofen there is a moderate correlation (r=0.28). NAG

show abstract

The Diagnostic Value of N-Acetyl-β-D-Glucosaminidase and Microalbumin Concentrations in Rheumatoid Arthritis

Cited by 9 publications

References 36 publications

Symmetric dimethyl arginine and N-acetyl- β-D-glucosaminidase lysosimyria of proximal renal tubules as a target for nephrotoxicity in patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs.

Symmetric dimethyl arginine and N-acetyl- β-D-glucosaminidase lysosimyria of proximal renal tubules as a target for nephrotoxicity in patients with rheumatoid arthritis treated with disease modifying antirheumatic drugs.

Some Aspects of Nephrotoxicity of Paracetamol and Ketoprofen in Patients with Rheumathoid Arthritis

Potency of Enzymes from Renal Tubules as Biotracers in Rheumatoid Arthritis Patients Treat With Most Used Antirheumatic Drugs

Contact Info

Product

Resources

About