The diagnostic value of PET/CT scanning in patients with cervical cancer: A prospective study

Loft, Annika; Berthelsen, Anne Kiil; Roed, Henrik; Ottosen, Christian; Lundvall, Lene; Knudsen, Janne Lehmann; Nedergaard, Lotte; Højgaard, Liselotte; Engelholm, Svend Aage

doi:10.1016/j.ygyno.2007.03.027

Cited by 157 publications

(103 citation statements)

References 18 publications

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“…[6][7][8]19,20 In cervical cancer, 18 F-FDG-PET or PET/CT has detected unsuspected bone metastasis. 21,22 However, to our knowledge, no large-scale study has been performed to compare the performances of 18 F-FDG-PET and CT or MR imaging in patients with cervical cancer. The objective of the current study was to clarify this issue and included a large number of patients with cervical cancer who received both PET and CT or MR imaging in a single institution.…”

Section: Discussionmentioning

confidence: 99%

Detection of hematogenous bone metastasis in cervical cancer

Liu

Yen

Chen

et al. 2009

Cancer

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BACKGROUND:In this large‐scale, retrospective study, the authors evaluated the diagnostic performances of computed tomography (CT), magnetic resonance (MR) imaging, and 18F‐fluorodeoxyglucose‐positron emission tomography (18F‐FDG–PET) in detecting hematogenous bone metastasis in patients with cervical cancer. The associated risk factors also were analyzed.METHODS:Patients with invasive cervical cancer who had both 18F‐FDG–PET studies and CT or MR imaging studies were selected. Patients who had either International Federation of Gynecology and Obstetrics (FIGO) stage III/IV disease or positive lymph node metastasis at the time of primary staging and patients who had suspected recurrent disease were included in the analyses. The diagnostic performances of PET was compared with the performance of CT and MR imaging by using the area under the receiver‐operating‐characteristic curve (AUC). Both univariate and multivariate analyses were applied to assess the risk factors for hematogenous bone metastasis at primary staging.RESULTS:PET was more sensitive than CT (P = .004) and was more specific than MR imaging (P = .04). The diagnostic performance of PET was significantly superior to the performance CT (AUC, 0.964 vs 0.662; P < .001) and MR (AUC, 0.966 vs 0.833; P = .033). Both FIGO stage and the extent of lymph node metastases were associated with hematogenous bone metastasis in univariate analysis. However, the extent of lymph node metastases was the only significant risk factor in multivariate analysis (P = .025).CONCLUSIONS:The current study demonstrated the superiority of 18F‐FDG–PET over CT and MR imaging for detecting hematogenous bone metastasis in patients with advanced cervical cancer. Hematogenous bone metastasis in cervical cancer was associated with the extent of lymph node metastases rather than with FIGO stage. Cancer 2009. © 2009 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Detection of hematogenous bone metastasis in cervical cancer

Liu

Yen

Chen

et al. 2009

Cancer

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“…CT detected enlarged pelvic lymph nodes and para-aortic lymph nodes in 20 and 7 patients, respectively, whereas PET detected abnormal FDG uptake in pelvic lymph nodes in 67, in para-aortic lymph nodes in 21 and in supraclavicular lymph nodes in 8. Based on para-aortic lymph node status, the 2-year progression-free survival rate was 64% in CT-negative and PET-negative patients, 18% in CT-negative and PET-positive patients and 14% in CT-positive and PET-positive patients [7].…”

Section: Role Of Imaging In Stagingmentioning

confidence: 99%

Radiation for Gynaecological Malignancies

Dasari¹,

Vivekanandam²,

Raghava³

2017

Radiotherapy

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Gynaecological malignancies are the most common cancers of women and they contribute to the signiicant amount of mortality. Women in developing countries are diagnosed in late stages and hence radiation is the common modality of therapy. Radiation is required in managing 80-90% of women with carcinoma cervix, 60% of women with endometrial cancer and 50% of women with carcinoma vulva. The stage of the disease is the most important factor in survival and counselling is essential to ensure complete therapy. Radiation is used as a primary therapy, adjuvant therapy, neo-adjuvant therapy and as palliation. The techniques include external beam radiation and brachytherapy or the combination of both. The newer techniques include IMRT-, IGRT-and PET-CTguided therapies. Side efects/complications occur as acute during therapy, subacute within 3 months and chronic after 6 months. Management of these side efects is essential for increasing compliance of the patient so as to achieve high cure rates. Management of recurrent disease is a challenge and requires multidisciplinary approach involving Gynaecological Oncologist, Radiation Oncologist and Surgical Oncologist.

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“…Korzyści wynikające z przedoperacyjnej oceny stopnia zaawansowania raka szyjki macicy, ze szczególnym uwzględ-nieniem układu chłonnego, są podkreślane przez wielu autorów [14][15][16]. Udowodniono, że stan węzłów chłonnych w raku szyjki macicy jest niezależnym czynnikiem rokowniczym, ponieważ przeżycia 5-letnie wynoszą odpowiednio 42-67% w grupie osób z wykrytymi przerzutami węzłowy-mi w stosunku do 87-92% wśród pacjentek bez zajęcia układu chłonnego [14].…”

Section: Dyskusjaunclassified

“…Wyniki badań przeprowadzonych na podobnych, nielicznych populacjach pacjentów (21-54 osób) określają czułość tego badania na 38-86% [15,18]. Podkreśla się za to inne zalety badania pozytonowego, a mianowicie możliwość wykrycia przerzutów odległych, np.…”

Section: Dyskusjaunclassified

The maximal standardized uptake value is a predictive factor of pelvic lymph node involvement in patients with early stage cervical carcinoma

Wiśniewski¹,

Terlikiewicz²,

Lebioda³

et al. 2010

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The diagnostic value of PET/CT scanning in patients with cervical cancer: A prospective study

Cited by 157 publications

References 18 publications

Detection of hematogenous bone metastasis in cervical cancer

Detection of hematogenous bone metastasis in cervical cancer

Radiation for Gynaecological Malignancies

The maximal standardized uptake value is a predictive factor of pelvic lymph node involvement in patients with early stage cervical carcinoma

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